结直肠侧向发育型肿瘤的诊疗研究进展
Advances in Diagnosis and Treatment of Colorectal Laterally Spreading Tumors
摘要: 结直肠侧向发育型肿瘤是一类起源于大肠黏膜的表浅型肿瘤,这类病变通常直径大于10 mm,沿肠壁黏膜呈侧向扩展或环肠壁生长,很少垂直浸润生长,具有较高的发病率及癌变率。随着近年来内镜技术的更新及各种辅助技术的发展,结直肠侧向发育型肿瘤的漏诊率及癌变率也有效降低,本文就结直肠侧向发育型肿瘤的诊断及治疗研究进展作一综述。
Abstract: Colorectal laterally spreading tumors are superficial tumors originating from the mucosa of intes-tine with high incidence and canceration rate. These lesions are usually defined as 10 mm or great-er in diameter, and extend laterally along the luminal wall or grow around the intestinal wall, with little vertical invasion. With the update of endoscopic technology and the development of various assistive technologies in recent years, the missed diagnosis rate and canceration rate of colorectal laterally spreading tumors have also been effectively reduced. This study reviews the research progress in diagnosis and treatment of colorectal laterally spreading tumors.
文章引用:陈琦, 勾雷, 王小波, 郭海洋, 陶杰, 王显飞. 结直肠侧向发育型肿瘤的诊疗研究进展[J]. 临床医学进展, 2022, 12(11): 10175-10183. https://doi.org/10.12677/ACM.2022.12111467

参考文献

[1] Bray, F., Ferlay, J., Soerjomataram, I., et al. (2018) Global Cancer Statistics 2018: Globocan Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 68, 394-424. [Google Scholar] [CrossRef] [PubMed]
[2] Kudo, S. (1993) Endoscopic Mucosal Resection of Flat and Depressed Types of Early Colorectal-Cancer. Endoscopy, 25, 455-461. [Google Scholar] [CrossRef] [PubMed]
[3] Hurl-stone, D.P., Korulla, C. and Lobo, A.J. (2002) Colorectal Laterally Spreading Tumors: Clinical Evaluation and Endo-scopic Strategies Updated. Journal of Gastroenterology and Hepatology, 17, 1344-1345. [Google Scholar] [CrossRef] [PubMed]
[4] 冯轶, 牛应林, 李鹏, 吕富靖, 冀明. 结直肠侧向发育型肿瘤的内镜表现及病理特点研究[J]. 中国内镜杂志, 2019, 25(1): 79-84.
[5] Bogie, R.M.M., Winkens, B., Retra, S.J.J., et al. (2021) Metachronous Neoplasms in Patients with Laterally Spreading Tumours During Surveillance. United European Gastroenterology Journal, 9, 378-387. [Google Scholar] [CrossRef] [PubMed]
[6] Ishigaki, T., Kudo, S., Miyachi, H., et al. (2020) Treatment Poli-cy for Colonic Laterally Spreading Tumors Based On Each Clinicopathologic Feature of 4 Subtypes: Actual Status of Pseudo-Depressed Type. Gastrointestinal Endoscopy, 92, 1083-1094. [Google Scholar] [CrossRef] [PubMed]
[7] 赵伟, 王利平, 耿丽媛, 王毓麟. 不同组织学类型结直肠侧向发育型肿瘤的内镜特点及癌变因素分析[J]. 中国临床医生杂志, 2021, 49(11): 1331-1334.
[8] 张菊嫦, 王学青, 李爱民, 刘思德. 结直肠侧向发育型肿瘤的临床病理特征和治疗方法的发展趋势分析[J]. 中华消化杂志, 2017, 37(2): 88-93.
[9] Kudo, S., Kashida, H., Nakajima, T., Tamura, S. and Nakajo, K. (1997) Endoscopic Diagnosis and Treatment of Early Colorectal Cancer. World Journal of Surgery, 21, 694-701. [Google Scholar] [CrossRef] [PubMed]
[10] Bogie, R.M.M., Veldman, M.H.J., Snijders, L.A.R.S., Winkens, B., et al. (2018) Endoscopic Subtypes of Colorectal Laterally Spreading Tumors (LSTs) and the Risk of Submucosal Inva-sion: A Meta-Analysis. Endoscopy, 50, 263-282. [Google Scholar] [CrossRef] [PubMed]
[11] Kudo, S.E., Lambert, R., Allen, J.I., et al. (2008) Nonpolypoid Neo-plastic Lesions of the Colorectal Mucosa. Gastrointestinal Endoscopy, 68, S3-S47. [Google Scholar] [CrossRef] [PubMed]
[12] Kudo, S., Kashida, H., Tamura, T., et al. (2000) Colonoscopic Di-agnosis and Management of Nonpolypoid Early Colorectal Cancer. World Journal of Surgery, 24, 1081-1090. [Google Scholar] [CrossRef] [PubMed]
[13] Kudo, S.E., Tamura, S., Nakajima, T., et al. (1996) Diagnosis of Colorectal Tumorous Lesions by Magnifying Endoscopy. Gastrointestinal Endoscopy, 44, 8-14. [Google Scholar] [CrossRef
[14] Zhang, Y., Chen, H., Zhou, X., Pan, W., et al. (2020) Di-agnostic Efficacy of the Japan Narrow-Band-Imaging Expert Team and Pit Pattern Classifications for Colorectal Lesions: A Meta-Analysis. World Journal of Gastroenterology, 26, 6279-6294. [Google Scholar] [CrossRef] [PubMed]
[15] Chen X., Cai, J., Feng, J., et al. (2019) A Clinical Study of Pre-operative Endoscopic Assessment of the Invasion Depth of Colorectal Laterally Spreading Tumor. Chinese Journal of Digestive Endoscopy, 36, 474-478.
[16] 王梓桦, 余捷, 杨世英, 薛寒冰. 窄带光成像内镜下JNET分型对大肠侧向发育型肿瘤的诊断价值[J]. 中华消化内镜杂志, 2019, 36(10): 725-730.
[17] Sano, Y., Tanaka, S., Kudo, S., et al. (2016) Narrow-Band Imaging (NBI) Magnifying Endoscopic Classification of Colorectal Tumors Proposed by the Japan NBI Expert Team. Digestive Endoscopy, 28, 526-533. [Google Scholar] [CrossRef] [PubMed]
[18] Fukuzawa, M., Saito, Y., Matsuda, T., et al. (2010) Effectiveness of Nar-row-Band Imaging Magnification for Invasion Depth in Early Colorectal Cancer. World Journal of Gastroenterology, 16, 1727-1734. [Google Scholar] [CrossRef] [PubMed]
[19] Yue, W., Liu, Y., Huang, J., et al. (2019) Colorectal Laterally Spreading Tumours: Subtype Evaluation by EUS and BLI and Outcome of ESD. Acta Gastro-Enterologica Belgica, 82, 19-26.
[20] Huang, S., Tan, W., Peng, Q., et al. (2021) Blue Laser Imaging Combined with JNET (Japan NBI Expert Team) Classification for Pathological Prediction of Colorectal Laterally Spreading Tumors. Surgical Endoscopy, 35, 5430-5440. [Google Scholar] [CrossRef] [PubMed]
[21] Tan, X., Zhao, R., Sun, Y., et al. (2021) Endoscopic Ultraso-nography Improving the Operation Effect for Detecting Precisely the Origin and Histology Characteristics of Esophageal Leiomyoma. Acta Anatomica Sinica, 52, 966-971.
[22] Akasu, T., Kondo, H., Moriya, Y., et al. (2000) Endorectal Ul-trasonography and Treatment of Early Rectal Cancer. World Journal of Surgery, 24, 1061-1068. [Google Scholar] [CrossRef] [PubMed]
[23] 莫波, 杜超, 乔丽娟, 杨明, 陈虹彬, 徐辉. 蓝激光成像技术联合微探头超声内镜预测早期结直肠癌浸润深度的诊断价值[J]. 西部医学, 2022, 34(8): 1187-1192.
[24] Zhou, G., Xiao, X., Tu, M., et al. (2020) Computer Aided Detection for Laterally Spreading Tumors and Sessile Serrated Adeno-mas During Colonoscopy. PLOS ONE, 15, e0231880. [Google Scholar] [CrossRef] [PubMed]
[25] Togashi, K., Utano, K., Kijima, S., et al. (2014) Laterally Spreading Tumors: Limitations of Computed Tomography Colonography. World Journal of Gastroenterology, 20, 17552-17557. [Google Scholar] [CrossRef] [PubMed]
[26] Igawa, A., Oka, S., Tanaka, S., Otani, I., Kunihara, S. and Chayama K. (2017) Evaluation for the Clinical Efficacy of Colon Capsule Endoscopy in the Detection of Laterally Spreading Tumors. Digestion, 95, 43-48. [Google Scholar] [CrossRef] [PubMed]
[27] Gao, Q. and Sun, M. (2018) Endoscopic Diagnosis and Treatment of 403 Cases of Laterally Spreading Tumor in Colon. Chinese Journal of Digestive Endoscopy, 35, 625-629.
[28] Saito, T., Kobayashi, K., Sada, M., et al. (2019) Comparison of the Histopathological Characteristics of Large Colorectal Laterally Spreading Tumors According to Growth Pattern. Journal of the Anus, Rectum and Colon, 3, 152-159. [Google Scholar] [CrossRef] [PubMed]
[29] Russo, P., Barbeiro, S., Awadie, H., et al. (2019) Management of Colorectal Laterally Spreading Tumors: A Systematic Review and Meta-Analysis. Endoscopy International Open, 7, E239-E259. [Google Scholar] [CrossRef] [PubMed]
[30] Kobayashi, K., Tanaka, S., Murakami, Y., et al. (2020) Pre-dictors of Invasive Cancer of Large Laterally Spreading Colorectal Tumors: A Multicenter Study in Japan. JGH Open, 4, 83-89. [Google Scholar] [CrossRef] [PubMed]
[31] Nishizawa, T. and Yahagi, N. (2017) Endoscopic Mucosal Resec-tion and Endoscopic Submucosal Dissection: Technique and New Directions. Current Opinion in Gastroenterology, 33, 315-319. [Google Scholar] [CrossRef
[32] Hao, X., Li, P., Wang, Y., et al. (2022) Predictors for Ma-lignant Potential and Deep Submucosal Invasion in Colorectal Laterally Spreading Tumors. World Journal of Gastroin-testinal Oncology, 14, 1337-1347. [Google Scholar] [CrossRef] [PubMed]
[33] Jung, J., Hong, J., Oh, H., et al. (2019) Clinical Outcomes of En-doscopic Resection for Colorectal Laterally Spreading Tumors with Advanced Histology. Surgical Endoscopy, 33, 2562-2571. [Google Scholar] [CrossRef] [PubMed]
[34] Sekiguchi, M., Igarashi, A., Mizuguchi, Y., et al. (2022) Cost-Effectiveness Analysis of Endoscopic Resection for Colorectal Laterally Spreading Tumors: Endoscopic Submucosal Dissection versus Piecemeal Endoscopic Mucosal Resection. Digestive Endoscopy, 34, 553-568. [Google Scholar] [CrossRef] [PubMed]
[35] 谈涛, 李蜀豫. 预切开内镜下黏膜切除术在结直肠侧向发育型肿瘤治疗中的应用价值[J]. 世界华人消化杂志, 2020, 28(24): 1272-1278.
[36] 金燕, 龚镭, 唐学军, 彭晓斌, 谈春晓, 王小云, 华萍, 任元梅, 周平红. 预切开内镜黏膜切除术诊治结肠侧向发育型肿瘤的临床疗效评价[J]. 中国内镜杂志, 2016, 22(8): 94-98.
[37] Okamoto, K., Muguruma, N., Kagemoto, K., et al. (2017) Efficacy of Hybrid Endoscopic Submucosal Dissection (ESD) as a Rescue Treatment in Difficult Colorectal ESD Cases. Digestive Endoscopy, 29, 45-52. [Google Scholar] [CrossRef] [PubMed]
[38] Jin, Y., Gong, L., Wang, X., Jin, S., et al. (2020) Indication Analysis of Therapeutic Effects of Pre-Cut-Endoscopic Mucosal Resection on Colorectal Lateral Spreading Tumors (with Video). Chinese Journal of Digestive Endoscopy, 37, 717-721.
[39] McCarty, T.R., Bazarbashi, A.N., Thompson, C.C. and Ai-hara, H. (2021) Hybrid Endoscopic Submucosal Dissection (ESD) Compared with Conventional ESD for Colorectal Le-sions: A Systematic Review and Meta-Analysis. Endoscopy, 53, 1048-1058. [Google Scholar] [CrossRef] [PubMed]
[40] Li, D., Liu, X., Huang, C., et al. (2021) Pathological Analysis and En-doscopic Characteristics of Colorectal Laterally Spreading Tumors. Cancer Management and Research, 13, 1137-1144. [Google Scholar] [CrossRef
[41] 孙素琴. 内镜黏膜下剥离术治疗结直肠侧向发育型肿瘤的价值[J]. 中国继续医学教育, 2021, 13(28): 135-137.
[42] Musquer, N. (2016) French Comment on Article: Endoscopic Predictors of Deep Submucosal Invasion in Colorectal Laterally Spreading Tumors. Endoscopy, 48, Article No. 506. [Google Scholar] [CrossRef] [PubMed]
[43] Zou, J., Chai, N., Zhai, Y., et al. (2020) Endoscopic Resection for Colorectal Laterally Spreading Tumors. Chinese Journal of Digestive Endoscopy, 37, 169-173.
[44] Zhu, M., Xu, Y., Yu, L., et al. (2022) Endoscopic Submucosal Dissection for Colorectal Laterally Spreading Tumors: Clinical Outcomes and Predictors of Technical Difficulty. Journal of Digestive Diseases, 23, 228-236. [Google Scholar] [CrossRef] [PubMed]
[45] 沈波, 梅娟, 钱昌, 周爱红. 牙线牵引金属夹缝合结直肠内镜黏膜下剥离术后创面的临床应用[J]. 中国内镜杂志, 2021, 27(8): 76-79.
[46] Shichijo, S., Takeuchi, Y., Waki, K., et al. (2020) Pulley Traction-Assisted Endoscopic Submucosal Dissection with Hemostatic Forceps for a Laterally Spread-ing Tumor in the Ascending Colon. VideoGIE, 5, 684-685. [Google Scholar] [CrossRef] [PubMed]
[47] Matsuzaki, I., Yamauchi, H., Goto, N., et al. (2020) Magnetic Anchor-Guided Endoscopic Submucosal Dissection Using a Stainless Steel Anchor. Endoscopy, 52, E80-E81. [Google Scholar] [CrossRef] [PubMed]
[48] Ritsuno, H., Sakamoto, N., Osada, T., Goto, S.P., et al. (2014) Prospec-tive Clinical Trial of Traction Device-Assisted Endoscopic Submucosal Dissection of Large Superficial Colorectal Tu-mors Using the S-O Clip. Surgical Endoscopy, 28, 3143-3149. [Google Scholar] [CrossRef] [PubMed]
[49] 金燕平, 胡柯峰, 叶国良, 丁勇, 刘青青, 张新军. 自制肠内牵引器在结直肠内镜黏膜下剥离术中的应用[J]. 现代实用医学, 2020, 32(1): 55-56.
[50] 陈相波, 宋玉琼, 许婷婷, 何壬松, 王育斌. 橡皮圈腔内牵引辅助内镜黏膜下剥离术在右半结肠侧向发育型肿瘤治疗中的应用[J]. 精准医学杂志, 2022, 37(3): 204-207.
[51] Zou, J., Chai, N., Linghu, E., et al. (2021) Efficacy and Safety of Endoscopic Submucosal Tunnel Dissection for Rectal Laterally Spreading Tumors. Surgical Endoscopy, 35, 4356-4362. [Google Scholar] [CrossRef] [PubMed]
[52] Tan, L., Tan, Y., Wang, H. and Liu, D. (2020) Single Tunnel-Assisted Endoscopic Submucosal Dissection for a 13-Cm Giant Colorectal Laterally Spreading Tumor. Revista Espanola De EnfermedadesDigestivas, 112, 150-151. [Google Scholar] [CrossRef] [PubMed]
[53] Aslan, F., Akpinar, Z., Yurtlu, D.A., et al. (2017) A Compar-ison of Standard Endoscopic Submucosal Dissection Technique to the New Single Tunneling Technique in Giant Later-ally Spreading Tumors. Gastrointestinal Endoscopy, 85, B103-B104. [Google Scholar] [CrossRef
[54] Gong, W. and Huang, S. (2017) Double Tunnel Endoscopic Sub-mucosal Tunnel Dissection for Rectal Circumferential Laterally Spreading Tumor. American Journal of Gastroenterology, 112, S875. [Google Scholar] [CrossRef] [PubMed]
[55] Inoue, T., Koyama, F., Kuge, H., et al. (2018) Short-Term Outcomes of Endoscopic Submucosal Dissection versus Laparoscopic Surgery for Colorectal Neoplasms: An Observa-tional Study. Journal of the Anus, Rectum and Colon, 2, 97-102. [Google Scholar] [CrossRef] [PubMed]
[56] 胡东明. 电子结肠镜联合腹腔镜治疗结直肠巨大侧向发育型肿瘤的临床疗效观察[J]. 吉林医学, 2018, 39(8): 1459-1460.