主动脉夹层中凝血功能障碍研究进展

Research Progress of Coagulopathy in Aortic Dissection

摘要: 主动脉夹层是指主动脉腔内血流从主动脉撕裂膜进入至主动脉中膜层后形成的夹层血肿病变，导致中膜分离。患者发病后易并发心律失常、心脏栓塞等并发症，严重危害到了患者的身心健康，具有较高的致死风险。主动脉夹层的发病机制在当前的临床上尚未明确，明确其发病机制是采取有效预防和治疗措施的关键，而凝血功能异常在主动脉夹层的发生及发展过程中始终伴随，主动脉夹层的手术治疗也会对患者凝血功能造成影响，推测凝血功能异常可能参与至主动脉夹层发病及病情进展过程中，还可能影响其预后。本文先针对主动脉夹层发病后不同时期的凝血功能改变进行分析，再对主动脉夹层手术治疗对凝血功能的影响进行分析，再阐述主动脉夹层凝血功能管理，以总结主动脉夹层发生发展及治疗与凝血功能的研究进展。

Abstract: Aortic dissection refers to the dissection hematoma formed after the blood flow in the aortic cavity enters the aortic tunica media from the torn aortic membrane, which leads to the separation of the tunica media. Patients are prone to complications such as arrhythmia and cardiac embolism after the onset of the disease, which seriously endangers the physical and mental health of patients and has a high risk of death. At present, the pathogenesis of aortic dissection is not clear clinically, and it is the key to take effective prevention and treatment measures. However, the abnormal coagulation function is always accompanied in the occurrence and development of aortic dissection, and the surgical treatment of aortic dissection will also affect the coagulation function of patients. It is spec-ulated that the abnormal coagulation function may be involved in the onset and progress of aortic dissection, and may also affect its prognosis. This article first analyzes the changes of coagulation function in different periods after the onset of aortic dissection, then analyzes the influence of sur-gical treatment of aortic dissection on coagulation function, and then expounds the management of coagulation function of aortic dissection, so as to summarize the research progress of occurrence and development of aortic dissection, treatment and coagulation function.