皮肌炎并发恶性肿瘤一例

A Case of Dermatomyositis Complicated with Malignant Tumors

摘要: 特发性炎性肌病(IIMs)，简称肌炎，以骨骼肌无力和慢性炎症为特征。其他器官也经常受累，包括皮肤、心脏、胃肠道和肺。根据临床和组织病理学发现的差异，已经确定了不同的IIM亚型，传统上分为多发性肌炎(PM)、皮肌炎(DM)和散发性包涵体肌炎(sIBM)。其中皮肌炎(DM)是一种多因素慢性自身免疫性疾病，具有特征性的皮肤变化，累及不同器官系统，包括肌肉、血管、关节、食管和肺，其种常见的肌外表现包括各种心脏异常、间质性肺疾病(ILD)和恶性肿瘤。DM与特定的恶性肿瘤有很强的相关性，包括卵巢癌、肺癌、胰腺癌、胃癌和结直肠癌。本文概述了皮肌炎的临床表现、治疗以及与恶性肿瘤的相关性。

Abstract: Idiopathic inflammatory myopathies (IIMs), referred to as myositis, characterized by skeletal mus-cle weakness and chronic inflammation. Other organs are often involved, including skin, heart, gas-trointestinal tract and lungs. According to the different clinical and histopathological findings, dif-ferent IIM subtypes have been identified, traditionally divided into multiple myositis (PM), derma-tomyositis (DM) and sporadic inclusion body myositis (sIBM). Dermatomyositis (DM) is a chronic autoimmune disease, has the characteristic of skin changes, involving different organ systems, in-cluding muscles, blood vessels, joints, esophagus and lung, and its common muscle performances include a variety of cardiac abnormalities, interstitial lung diseases (ILD) and malignant tumor. DM is strongly associated with specific malignancies, including ovarian, lung, pancreatic, gastric and colorectal cancers. This article summarized the clinical manifestation, treatment of dermatomyo-sitis and the correlation with malignant tumor.