|
[1]
|
Brooks, G.A. (2009) Cell-Cell and Intracellular Lactate Shuttles. The Journal of Physiology, 587, 5591-5600. [Google Scholar] [CrossRef] [PubMed]
|
|
[2]
|
Brooks, G.A. (2020) Lactate as a Fulcrum of Metabolism. Re-dox Biology, 35, Article ID: 101454. [Google Scholar] [CrossRef] [PubMed]
|
|
[3]
|
Zhang, L., Cao, J., Dong, L. and Lin, H. (2020) TiPARP Forms Nuclear Condensates to Degrade HIF-1α and Suppress Tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America, 117, 13447-13456. [Google Scholar] [CrossRef] [PubMed]
|
|
[4]
|
O’Neill, L.A., Kishton, R.J. and Rathmell, J. (2016) A Guide to Immunometabolism for Immunologists. Nature Reviews Immunology, 16, 553-565. [Google Scholar] [CrossRef] [PubMed]
|
|
[5]
|
Peng, M., et al. (2016) Aerobic Glycolysis Promotes T Helper 1 Cell Dif-ferentiation through an Epigenetic Mechanism. Science, 354, 481-484. [Google Scholar] [CrossRef] [PubMed]
|
|
[6]
|
Colegio, O.R., et al. (2014) Functional Polarization of Tu-mour-Associated Macrophages by Tumour-Derived Lactic Acid. Nature, 513, 559-563. [Google Scholar] [CrossRef] [PubMed]
|
|
[7]
|
Zhang, D., et al. (2019) Metabolic Regulation of Gene Expression by Histone Lactylation. Nature, 574, 575-580. [Google Scholar] [CrossRef] [PubMed]
|
|
[8]
|
Rivadeneira, D.B. and Delgoffe, G.M. (2018) Antitumor T-Cell Reconditioning: Improving Metabolic Fitness for Optimal Cancer Immunotherapy. Clinical Cancer Research, 24, 2473-2481. [Google Scholar] [CrossRef]
|
|
[9]
|
Warburg, O., Wind, F. and Negelein, E. (1927) The Metab-olism of Tumors in the Body. The Journal of General Physiology, 8, 519-530. [Google Scholar] [CrossRef] [PubMed]
|
|
[10]
|
Sharma, N.K. and Pal, J.K. (2021) Metabolic Ink Lactate Modulates Epigenomic Landscape: A Concerted Role of Pro-Tumor Microenvironment and Macroenvironment during Carcinogene-sis. Current Molecular Medicine, 21, 177-181. [Google Scholar] [CrossRef] [PubMed]
|
|
[11]
|
Mueckler, M. and Thorens, B. (2013) The SLC2 (GLUT) Family of Membrane Transporters. Molecular Aspects of Medicine, 34, 121-138. [Google Scholar] [CrossRef] [PubMed]
|
|
[12]
|
Amann, T., et al. (2009) GLUT1 Expression Is Increased in Hepatocellular Carcinoma and Promotes Tumorigenesis. The American Journal of Pathology, 174, 1544-1552. [Google Scholar] [CrossRef] [PubMed]
|
|
[13]
|
Li, X., et al. (2020) Enhanced Glucose Metabolism Mediated by CD147 Contributes to Immunosuppression in Hepatocellular Carcinoma. Cancer Immunology, Immunotherapy, 69, 535-548. [Google Scholar] [CrossRef] [PubMed]
|
|
[14]
|
Hu, Y., Yang, Z., Bao, D., Ni, J.-S. and Lou, J. (2019) miR-455-5p Suppresses Hepatocellular Carcinoma Cell Growth and Invasion via IGF-1R/AKT/GLUT1 Pathway by Targeting IGF-1R. Pathology-Research and Practice, 215, Article ID: 152674. [Google Scholar] [CrossRef] [PubMed]
|
|
[15]
|
Feng, J., et al. (2019) PKM2 Is the Target of Proanthocyanidin B2 during the Inhibition of Hepatocellular Carcinoma. Journal of Experimental & Clinical Cancer Research, 38, Article No. 204. [Google Scholar] [CrossRef] [PubMed]
|
|
[16]
|
Hong, S.M., Lee, Y.-K., Park, I., Kwon, S., Min, S. and Yoon, G. (2019) Lactic Acidosis Caused by Repressed Lactate Dehydrogenase Subunit B Expression Down-Regulates Mitochon-drial Oxidative Phosphorylation via the Pyruvate Dehydrogenase (PDH)—PDH Kinase Axis. Journal of Biological Chemistry, 294, 7810-7820. [Google Scholar] [CrossRef]
|
|
[17]
|
Hua, S., Liu, C., Liu, L. and Wu, D. (2018) miR-142-3p Inhibits Aerobic Glycolysis and Cell Proliferation in Hepatocellular Carcinoma via Targeting LDHA. Biochemical and Biophysi-cal Research Communications, 496, 947-954. [Google Scholar] [CrossRef] [PubMed]
|
|
[18]
|
Guo, Y., et al. (2019) Combined Aberrant Expression of NDRG2 and LDHA Predicts Hepatocellular Carcinoma Prognosis and Mediates the Anti-Tumor Effect of Gemcitabine. Interna-tional Journal of Biological Sciences, 15, 1771-1786. [Google Scholar] [CrossRef] [PubMed]
|
|
[19]
|
Weng, Q., et al. (2020) Integrated Analyses Identify miR-34c-3p/MAGI3 Axis for the Warburg Metabolism in Hepatocellular Carcinoma. The FASEB Journal, 34, 5420-5434. [Google Scholar] [CrossRef]
|
|
[20]
|
张慧芳, 曾志军, 周艳宏. 乳酸代谢——肿瘤治疗新靶点[J]. 生物化学与生物物理进展, 2021, 48(2): 147-157.
|
|
[21]
|
Zhao, Y., et al. (2019) Targeted Inhibition of MCT4 Disrupts Intra-cellular pH Homeostasis and Confers Self-Regulated Apoptosis on Hepatocellular Carcinoma. Experimental Cell Re-search, 384, Article ID: 111591. [Google Scholar] [CrossRef] [PubMed]
|
|
[22]
|
Liu, H.T., et al. (2019) HSF1: A Mediator in Metabolic Altera-tion of Hepatocellular Carcinoma Cells in Cross-Talking with Tumor-Associated Macrophages. American Journal of Translational Research, 11, 5054-5064.
|
|
[23]
|
Pucino, V., et al. (2019) Lactate Buildup at the Site of Chronic Inflamma-tion Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring. Cell Metabolism, 30, 1055-1074. [Google Scholar] [CrossRef] [PubMed]
|
|
[24]
|
Certo, M., Marone, G., de Paulis, A., Mauro, C. and Pucino, V. (2020) Lactate: Fueling the Fire Starter. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 12, e1474. [Google Scholar] [CrossRef] [PubMed]
|
|
[25]
|
Pucino, V., Bombardieri, M., Pitzalis, C. and Mauro, C. (2017) Lactate at the Crossroads of Metabolism, Inflammation, and Autoimmunity. European Journal of Immunology, 47, 14-21. [Google Scholar] [CrossRef] [PubMed]
|
|
[26]
|
Certo, M., et al. (2021) Endothelial Cell and T-Cell Crosstalk: Targeting Metabolism as a Therapeutic Approach in Chronic Inflammation. British Journal of Pharmacology, 178, 2041-2059. [Google Scholar] [CrossRef] [PubMed]
|
|
[27]
|
Lee, D.C., et al. (2015) A Lactate-Induced Response to Hypoxia. Cell, 161, 595-609. [Google Scholar] [CrossRef] [PubMed]
|
|
[28]
|
Haas, R., et al. (2015) Lactate Regulates Metabolic and Pro-Inflammatory Circuits in Control of T Cell Migration and Effector Functions. PLOS Biology, 13, e1002202. [Google Scholar] [CrossRef] [PubMed]
|
|
[29]
|
Yang, Z., Fujii, H., Mohan, S.V., Goronzy, J.J. and Weyand, C.M. (2013) Phosphofructokinase Deficiency Impairs ATP Generation, Autophagy, and Redox Balance in Rheumatoid Arthritis T Cells. Journal of Experimental Medicine, 210, 2119-2134. [Google Scholar] [CrossRef] [PubMed]
|
|
[30]
|
Yang, Z., et al. (2016) Restoring Oxidant Signaling Suppresses Proar-thritogenic T Cell Effector Functions in Rheumatoid Arthritis. Science Translational Medicine, 8, 331ra38. [Google Scholar] [CrossRef] [PubMed]
|
|
[31]
|
Sun, S., et al. (2021) Lactic Acid-Producing Probiotic Saccha-romyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Mzacrophage Pyroptosis and Modulating Gut Microbi-ota. Frontiers in Immunology, 12, Article ID: 777665. [Google Scholar] [CrossRef] [PubMed]
|
|
[32]
|
Gupta, G.S. (2022) The Lactate and the Lactate Dehydrogenase in Inflammatory Diseases and Major Risk Factors in COVID-19 Patients. Inflammation, 1-33. [Google Scholar] [CrossRef] [PubMed]
|
|
[33]
|
Soto-Heredero, G., Gómez de las Heras, M.M., Gaban-dé-Rodríguez, E., Oller, J. and Mittelbrunn, M. (2020) Glycolysis—A Key Player in the Inflammatory Response. The FEBS Journal, 287, 3350-3369. [Google Scholar] [CrossRef] [PubMed]
|
|
[34]
|
Palmieri, E.M., et al. (2020) Nitric Oxide Orchestrates Metabolic Rewiring in M1 Macrophages by Targeting Aconitase 2 and Pyruvate Dehydrogenase. Nature Communications, 11, Article No. 698. [Google Scholar] [CrossRef] [PubMed]
|
|
[35]
|
Greten, F.R. and Grivennikov, S.I. (2019) Inflammation and Cancer: Triggers, Mechanisms, and Consequences. Immunity, 51, 27-41. [Google Scholar] [CrossRef] [PubMed]
|
|
[36]
|
Morioka, S., et al. (2018) Efferocytosis Induces a Novel SLC Program to Promote Glucose Uptake and Lactate Release. Nature, 563, 714-718. [Google Scholar] [CrossRef] [PubMed]
|
|
[37]
|
Zhang, W., et al. (2019) Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. Cell, 178, 176-189. [Google Scholar] [CrossRef] [PubMed]
|
|
[38]
|
Peter, K., et al. (2015) Lactic Acid Delays the Inflammatory Re-sponse of Human Monocytes. Biochemical and Biophysical Research Communications, 457, 412-418. [Google Scholar] [CrossRef] [PubMed]
|
|
[39]
|
Dietl, K., et al. (2022) Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes. The Journal of Immunology, 184, 1200-1209. [Google Scholar] [CrossRef] [PubMed]
|
|
[40]
|
Liang, L., Liu, P., Deng, Y., Li, J. and Zhao, S. (2022) L-Lactate Inhibits Lipopolysaccharide-Induced Inflammation of Microglia in the Hippocampus. International Journal of Neurosci-ence, 1-8. [Google Scholar] [CrossRef] [PubMed]
|
|
[41]
|
Ippolito, L., Morandi, A., Giannoni, E. and Chiarugi, P. (2019) Lactate: A Metabolic Driver in the Tumour Landscape. Trends in Biochemical Sciences, 44, 153-166. [Google Scholar] [CrossRef] [PubMed]
|
|
[42]
|
Liu, N., et al. (2019) Lactate Inhibits ATP6V0d2 Expression in Tumor-Associated Macrophages to Promote HIF-2α- Mediated Tumor Progression. The Journal of Clinical Investiga-tion, 129, 631-646. [Google Scholar] [CrossRef]
|
|
[43]
|
Bohn, T., et al. (2018) Tumor Immunoevasion via Ac-idosis-Dependent Induction of Regulatory Tumor-Associated Macrophages. Nature Immunology, 19, 1319-1329. [Google Scholar] [CrossRef] [PubMed]
|
|
[44]
|
Watson, M.J., et al. (2021) Metabolic Support of Tu-mour-Infiltrating Regulatory T Cells by Lactic Acid. Nature, 591, 645-651. [Google Scholar] [CrossRef] [PubMed]
|
|
[45]
|
Zappasodi, R., et al. (2021) CTLA-4 Blockade Drives Loss of Treg Stability in Glycolysis-Low Tumours. Nature, 591, 652-658. [Google Scholar] [CrossRef] [PubMed]
|
|
[46]
|
Luo, Y., Li, L., Chen, X., Gou, H., Yan, K. and Xu, Y. (2022) Effects of Lactate in Immunosuppression and Inflammation: Progress and Prospects. International Reviews of Immunol-ogy, 41, 19-29. [Google Scholar] [CrossRef] [PubMed]
|
|
[47]
|
Irizarry-Caro, R.A., et al. (2020) TLR Signaling Adapter BCAP Regulates Inflammatory to Reparatory Macrophage Transition by Promoting Histone Lactylation. Proceedings of the National Academy of Sciences of the United States of America, 117, 30628-30638. [Google Scholar] [CrossRef] [PubMed]
|
|
[48]
|
Chu, X., et al. (2021) Lactylated Histone H3K18 as a Potential Bi-omarker for the Diagnosis and Predicting the Severity of Septic Shock. Frontiers in Immunology, 12, Article ID: 786666. [Google Scholar] [CrossRef] [PubMed]
|
|
[49]
|
Yang, K., et al. (2022) Lactate Promotes Macrophage HMGB1 Lactylation, Acetylation, and Exosomal Release in Polymicrobial Sepsis. Cell Death & Differentiation, 29, 133-146. [Google Scholar] [CrossRef] [PubMed]
|
|
[50]
|
Caielli, S., et al. (2021) Erythroid Mitochondrial Retention Trig-gers Myeloid-Dependent Type I Interferon in Human SLE. Cell, 184, 4464-4479. [Google Scholar] [CrossRef] [PubMed]
|
|
[51]
|
Ma, W., et al. (2022) Methylsulfonylmethane Protects against Lethal Dose MRSA-Induced Sepsis through Promoting M2 Macrophage Polarization. Molecular Immunology, 146, 69-77. [Google Scholar] [CrossRef] [PubMed]
|
|
[52]
|
Yu, J., et al. (2021) Histone Lactylation Drives Oncogenesis by Facilitating m6A Reader Protein YTHDF2 Expression in Ocular Melanoma. Genome Biology, 22, Article No. 85. [Google Scholar] [CrossRef] [PubMed]
|
|
[53]
|
Xiong, J., et al. (2022) Lactylation-Driven METTL3-Mediated RNA m6A Modification Promotes Immunosuppression of Tumor-Infiltrating Myeloid Cells. Molecular Cell, 82, 1660-1677. [Google Scholar] [CrossRef] [PubMed]
|
|
[54]
|
Gu, J., et al. (2022) Tumor Metabolite Lactate Pro-motes Tumorigenesis by Modulating MOESIN Lactylation and Enhancing TGF-β Signaling in Regulatory T Cells. Cell Reports, 39, Article ID: 110986. [Google Scholar] [CrossRef] [PubMed]
|
|
[55]
|
Yang, J., et al. (2022) A Positive Feedback Loop between Inac-tive VHL-Triggered Histone Lactylation and PDGFRβ Signaling Drives Clear Cell Renal Cell Carcinoma Progression. International Journal of Biological Sciences, 18, 3470- 3483. [Google Scholar] [CrossRef] [PubMed]
|
|
[56]
|
Pan, L., et al. (2022) Demethylzeylasteral Targets Lactate by Inhibiting Histone Lactylation to Suppress the Tumorigenicity of Liver Cancer Stem Cells. Pharmacological Research, 181, Article ID: 106270. [Google Scholar] [CrossRef] [PubMed]
|
|
[57]
|
Rocha-Ferreira, E. and Hristova, M. (2015) Antimicrobial Peptides and Complement in Neonatal Hypoxia-Ischemia Induced Brain Damage. Frontiers in Immunology, 6, Article ID: 00056. [Google Scholar] [CrossRef] [PubMed]
|
|
[58]
|
Ivashkiv, L.B. (2020) The Hypoxia-Lactate Axis Tempers Inflam-mation. Nature Reviews Immunology, 20, 85-86. [Google Scholar] [CrossRef] [PubMed]
|
|
[59]
|
Zhou, Y., Yang, L., Liu, X. and Wang, H. (2022) Lactylation May Be a Novel Posttranslational Modification in Inflammation in Neonatal Hypoxic-Ischemic Encephalopathy. Frontiers in Pharmacology, 13, Article ID: 926802. [Google Scholar] [CrossRef] [PubMed]
|
|
[60]
|
Jin, F., et al. (2021) Targeting Epigenetic Modifiers to Repro-gramme Macrophages in Non-Resolving Inflammation-Driven Atherosclerosis. European Heart Journal Open, 1, oeab022. [Google Scholar] [CrossRef] [PubMed]
|
|
[61]
|
Yang, W., et al. (2021) Hypoxic in Vitro Culture Reduces Histone Lactylation and Impairs Pre-Implantation Embryonic Development in Mice. Epigenetics & Chromatin, 14, Arti-cle No. 57. [Google Scholar] [CrossRef] [PubMed]
|
|
[62]
|
Jia, L., et al. (2021) Rheb-Regulated Mitochondrial Pyruvate Metabolism of Schwann Cells Linked to Axon Stability. Developmental Cell, 56, 2980-2994. [Google Scholar] [CrossRef] [PubMed]
|
|
[63]
|
Li, X., et al. (2022) Hypoxia Regulates Fibrosis-Related Genes via Histone Lactylation in the Placentas of Patients with Preeclampsia. Journal of Hypertension, 40, 1189-1198. [Google Scholar] [CrossRef]
|
|
[64]
|
Rabinowitz, J.D. and Enerbäck, S. (2020) Lactate: The Ugly Duckling of Energy Metabolism. Nature Metabolism, 2, 566-571. [Google Scholar] [CrossRef] [PubMed]
|
|
[65]
|
Sanità, P., et al. (2014) Tumor-Stroma Metabolic Relationship Based on Lactate Shuttle Can Sustain Prostate Cancer Progression. BMC Cancer, 14, Article No. 154. [Google Scholar] [CrossRef] [PubMed]
|
|
[66]
|
Choi, S.Y.C., et al. (2016) The MCT4 Gene: A Novel, Potential Target for Therapy of Advanced Prostate CancerMCT4 as a Potential Therapeutic Target for CRPC. Clinical Cancer Re-search, 22, 2721-2733. [Google Scholar] [CrossRef]
|
|
[67]
|
Choi, S.Y.C., et al. (2018) Targeting MCT 4 to Reduce Lac-tic Acid Secretion and Glycolysis for Treatment of Neuroendocrine Prostate Cancer. Cancer Medicine, 7, 3385-3392.
https://Doi.Org/10.1002/Cam4.1587
|
|
[68]
|
Zhang, Y., et al. (2022) Lactate: The Mediator of Metabolism and Im-munosuppression. Frontiers in Endocrinology, 13, Article ID: 901495. [Google Scholar] [CrossRef] [PubMed]
|