短链脂肪酸在妊娠期高血压疾病中的作用和机制研究进展
Research Progress on the Role and Mechanism of Short Chain Fatty Acidsin Hypertensive Disorders of Pregnancy
DOI: 10.12677/ACM.2022.12111490, PDF,  被引量   
作者: 李晶晶, 柳婷婷, 李振英, 张一凡：甘肃中医药大学第一临床医学院，甘肃 兰州；甘肃省人民医院，甘肃 兰州；孙晓彤*：甘肃省人民医院，甘肃 兰州
关键词: 肠道菌群；短链脂肪酸；妊娠期高血压疾病；高血压；Intestinal Flora； Short Chain Fatty Acids； Hypertensive Disorders of Pregnancy； Hypertension
摘要: 作为肠道细菌代谢的产物，短链脂肪(Short-chain fatty acids, SCFAs)代谢变化与孕产妇健康密切相关。最常见的研究种类包括丁酸、丙酸和乙酸，它们的比例因饮食、年龄、并存疾病和其他因素而异。SCFA作为信号分子，不仅通过改变组蛋白乙酰化(histone deacetylases, HDAC)作为表观基因组的重要调节器，而且还作为G蛋白耦联受体(G protein-coupled receptors, GPRs)的内源性配体，介导机体的多种反应，因此，孕期短链脂肪酸代谢紊乱对孕产妇健康至关重要。在这篇综述文章中，我们总结了目前关于SCFA的知识，它们对妊娠期母体高血压的潜在影响和可能的作用机制。
Abstract: As a product of intestinal bacteria metabolism, the metabolic changes of short-chain fatty acids (SCFAs) are closely related to maternal health. The most commonly studied categories include bu-tyric, propionic, and acetic acids, whose proportions vary with diet, age, coexisting diseases, and other factors. As a signaling molecule, SCFA not only acts as an important epigenome regulator by changing histone deacetylases (HDAC), but also acts as an endogenous ligand of G protein-coupled receptors (GPRs). It mediates various responses of the body. Therefore, the disorder of short chain fatty acid metabolism during pregnancy is very important for maternal health. In this review article, we summarize the current knowledge about SCFA, their potential effects on maternal hypertension during pregnancy and possible mechanisms of action.
文章引用：李晶晶, 孙晓彤, 柳婷婷, 李振英, 张一凡. 短链脂肪酸在妊娠期高血压疾病中的作用和机制研究进展[J]. 临床医学进展, 2022, 12(11): 10333-10341. https://doi.org/10.12677/ACM.2022.12111490

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