肝癌移植术后免疫监测研究进展

Research Progress of Immune Monitoring after Liver Cancer Transplantation

摘要: 肝移植是目前治疗肝癌重要的手段之一，但是受体仍然需要长期的免疫抑制药物治疗，肝癌肝移植术后短期和晚期发病原因都与免疫抑制有关，目前肝癌移植术后护理通常是监测肝脏生物化学及免疫抑制药物水平。然而肝癌移植术后病情发展往往与重大并发症相关，包括感染、排斥和复发，这表明目前的免疫监测存在不足。许多检测方法已经在研究环境中进行了测试，以确定用于预测临床事件的生物标志物，从而指导肝移植术后免疫抑制方案。然而，这些检测方法很难在研究环境之外的临床上普遍应用。在这篇综述中，讨论了用于评估肝癌肝移植术后免疫功能监测的检测方法及未来展望。

Abstract: Liver transplantation is one of the most important methods for the treatment of liver cancer, but the recipient still needs long-term immunosuppressive drug therapy, and the short-term and late causes of liver cancer after liver transplantation are related to immunosuppression. At present, nursing care after liver cancer transplantation is usually to monitor the level of liver biochemistry and immunosuppressive drugs. However, the disease progression after liver cancer transplantation is often associated with major complications, including infection, rejection and recurrence, which indicates that the current immune surveillance is inadequate. Many detection methods have been tested in the research environment to determine the biomarkers used to predict clinical events to guide immunosuppressive regimens after liver transplantation. However, these detection methods are difficult to be widely used in clinical practice outside the research environment. In this review, the detection methods and future prospects for the evaluation of immune function monitoring after liver transplantation for liver cancer are discussed.