YKT6在非小细胞肺癌中的表达及临床意义

Expression and Clinical Significance of YKT6 in Non-Small Cell Lung Cancer

摘要: 目的：探究YKT6在非小细胞肺癌中的表达情况，阐明YKT6表达与临床分期的关系以及对于非小细胞肺癌患者的诊断和预后价值。方法：通过TCGA、Ualcan、HPA等公共数据库，使用R语言(3.6.3版本) ggplot2包、pROC包、survival包等分析YKT6在非小细胞肺癌中的表达及其与预后的关系。结果：通过分析TCGA数据显示，YKT6在膀胱尿路上皮癌、乳腺癌等多种肿瘤中高表达。Ualcan数据库分析发现YKT6在肺腺癌和肺鳞癌组织中的表达水平高于癌旁组织，其表达与肺癌的病理分期呈显著相关。YKT6蛋白在肺腺癌和肺鳞癌组织中均呈中等水平以上的表达，而正常肺组织几乎不表达。K-M分析表明，YKT6的表达水平与肺腺癌患者的总生存呈显著负相关，而其表达上调对肺腺癌和肺鳞癌均具有诊断价值。结论：YKT6在非小细胞肺癌中表达上调，其表达与肺腺癌患者总生存显著相关，有望成为非小细胞肺癌诊断和治疗的潜在靶点。

Abstract: Objective: We aim to investigate YKT6 expression in non-small cell lung cancer (NSCLC), to define the connection between YKT6 expression and clinical stage, and to assess the significance of YKT6 in the diagnosis and prognosis of NSCLC patients. Methods: By utilizing TCGA, Ualcan, HPA and ggplot2 package, pROC package, and survival package in the R language (version 3.6.3), we were able to examine the expression of YKT6 in NSCLC and its relation to prognosis. Results: TCGA data analysis revealed that YKT6 was highly expressed in a variety of cancers, including bladder urothelial carci-noma and breast invasive carcinoma. Ualcan showed that YKT6 expression was substantially higher in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) than in neighboring tis-sues, and connected with the pathological stage. The expression of YKT6 protein was higher than moderate in LUAD and LUSC, but essentially nonexistent in normal lung tissue. In patients with LUAD, K-M analysis revealed a strong inverse relationship between YKT6 expression and overall survival (OS), and its up-regulation has diagnostic significance for both LUAD and LUSC. Conclusion: The expression of YKT6 is up-regulated in non-small cell lung cancer, and its expression is signifi-cantly related to the overall survival of patients with lung adenocarcinoma and is expected to be-come a potential target for the diagnosis and treatment of non-small cell lung cancer.