非酒精性脂肪性肝病与慢性乙型肝炎的相互影响及可能机制
Interaction and Possible Mechanism between Non-Alcoholic Fatty Liver Disease and Chronic Hepatitis B
摘要: 随着生活水平改善及方式转变，全球非酒精脂肪性肝病发病率逐年上升，未来可能成为肝移植首要原因；同时我国罹患慢性乙型肝炎人口多，其中共病患者数量不容忽视。本文就二者相互影响及可能机制作一概述。
Abstract: With the improvement of living standards and the change of lifestyle, the incidence of non-alcoholic fatty liver disease is increasing year by year worldwide, which may become the leading cause of liv-er transplantation in the future. At the same time, the population suffering from Chronic B virus liver disease is large in China, and the number of comorbidity patients cannot be ignored. This pa-per gives an overview of the interaction and possible mechanism between them.
文章引用：陈博诗, 俞慧宏. 非酒精性脂肪性肝病与慢性乙型肝炎的相互影响及可能机制[J]. 临床医学进展, 2022, 12(11): 10453-10458. https://doi.org/10.12677/ACM.2022.12111506

参考文献

[1] Cotter, T.G. and Rinella, M. (2020) Nonalcoholic Fatty Liver Disease 2020: The State of the Disease. Gastroenterology, 158, 1851-1864. [Google Scholar] [CrossRef] [PubMed]
[2] Zhou, J., Zhou, F., Wang, W., et al. (2020) Ep-idemiological Features of NAFLD from 1999 to 2018 in China. Hepatology, 71, 1851-1864. [Google Scholar] [CrossRef] [PubMed]
[3] (2018) Global Prevalence, Treatment, and Prevention of Hepatitis B Virus Infection in 2016: A Modelling Study. The Lancet Gastroenterology and Hepatology, 3, 383-403. [Google Scholar] [CrossRef] 
[4] Jelenik, T., Kaul, K., Séquaris, G., et al. (2017) Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver. Diabetes, 66, 2241-2253. [Google Scholar] [CrossRef] [PubMed]
[5] Tilg, H. and Moschen, A.R. (2010) Evolution of Inflammation in Nonal-coholic Fatty Liver Disease: The Multiple Parallel Hits Hypothesis. Hepatology, 52, 1836-1846. [Google Scholar] [CrossRef] [PubMed]
[6] Powell, E.E., Wong, V.W. and Rinella, M. (2021) Non-Alcoholic Fatty Liver Disease. The Lancet, 397, 2212-2224. [Google Scholar] [CrossRef] 
[7] Nassal, M. (2015) HBV cccDNA: Viral Persistence Reser-voir and Key Obstacle for a Cure of Chronic Hepatitis B. Gut, 64, 1972-1984. [Google Scholar] [CrossRef] [PubMed]
[8] Zhang, Z., Pan, Q., Duan, X.Y., et al. (2012) Fatty Liver Reduces Hepatitis B Virus Replication in a Genotype B Hepatitis B Virus Transgenic Mice Model. Journal of Gastroenterology and Hepatology, 27, 1858-1864. [Google Scholar] [CrossRef] [PubMed]
[9] Hu, D., Wang, H., Wang, H., et al. (2018) Non-Alcoholic Hepatic Steatosis Attenuates Hepatitis B Virus Replication in an HBV-Immunocompetent Mouse Model. Hepatology In-ternational, 12, 438-446. [Google Scholar] [CrossRef] [PubMed]
[10] Wang, M.M., Wang, G.S., Shen, F., et al. (2014) Hepatic Steato-sis is Highly Prevalent in Hepatitis B Patients and Negatively Associated with Virological Factors. Digestive Diseases and Sciences, 59, 2571-2579. [Google Scholar] [CrossRef] [PubMed]
[11] Chu, C.M., Lin, D.Y. and Liaw, Y.F. (2013) Clinical and Viro-logical Characteristics Post HBsAg Seroclearance in Hepatitis B Virus Carriers with Hepatic Steatosisversus Those without. Digestive Diseases and Sciences, 58, 275-281. [Google Scholar] [CrossRef] [PubMed]
[12] Mak, L.Y., Hui, R.W., Fung, J., et al. (2020) Diverse Effects of Hepatic Steatosis on Fibrosis Progression and Functional Cure in Virologically Quiescent Chronic Hepatitis B. Journal of Hepatology, 73, 800-806. [Google Scholar] [CrossRef] [PubMed]
[13] Kim, G.A., Lim, Y.S., Han, S., et al. (2018) High Risk of Hepato-cellular Carcinoma and Death in Patients with Immune-Tolerant-Phase Chronic Hepatitis B. Gut, 67, 945-952. [Google Scholar] [CrossRef] [PubMed]
[14] Sinn, D.H., Kim, S.E., Kim, B.K., et al. (2019) The Risk of Hepatocellular Carcinoma among Chronic Hepatitis B Virus-Infected Patients outside Current Treatment Criteria. Journal of Viral Hepatitis, 26, 1465-1472. [Google Scholar] [CrossRef] [PubMed]
[15] Chen, Y.C., Jeng, W.J., Hsu, C.W., et al. (2020) Impact of Hepatic Steato-sis on Treatment Response in Nuclesos(t)ide Analogue-Treated HBeAg-Positive Chronic Hepatitis B: A Retrospective Study. BMC Gastroenterology, 20, Article No. 146. [Google Scholar] [CrossRef] [PubMed]
[16] Ate, F., Yaln, Z.M. and Alan, S. (2011) Impact of Liver Steatosis on Response to Pegylated Interferon Therapy in Patients with Chronic Hepatitis B. World Journal of Gastroenterology, 17, 4517-4522. [Google Scholar] [CrossRef] [PubMed]
[17] Charatcharoenwitthaya, P., Pongpaibul, A., Kaosombatwattana, U., et al. (2017) The Prevalence of Steatohepatitis in Chronic Hepatitis B Patients and Its Impact on Disease Severity and Treatment Response. Liver International, 37, 542-551. [Google Scholar] [CrossRef] [PubMed]
[18] Chang, X.J., Shi, Y.W., Wang, J., et al. (2021) Influence of Weight Management on the Prognosis of Steatohepatitis in Chronic Hepatitis B Patients during Antiviral Treatment. Hepatobiliary & Pancreatic Diseases International, 20, 416-425. [Google Scholar] [CrossRef] [PubMed]
[19] Kim, D.S., Jeon, M.Y., Lee, H.W., et al. (2019) Influence of He-patic Steatosis on the Outcomes of Patients with Chronic Hepatitis B Treated with Entecavir and Tenofovir. Clinical and Molecular Hepatology, 25, 283-293. [Google Scholar] [CrossRef] [PubMed]
[20] Kim, K.H., Shin, H.J., Kim, K., et al. (2007) Hepatitis B Virus X Pro-tein Induces Hepatic Steatosis via Transcriptional Activation of SREBP1 and PPARgamma. Gastroenterology, 132, 1955-1967. [Google Scholar] [CrossRef] [PubMed]
[21] Kim, J.Y., Song, E.H., Lee, H.J., et al. (2010) HBx-Induced He-patic Steatosis and Apoptosis Are Regulated by TNFR1- and NF-kappaB-Dependent Pathways. Journal of Molecular Biology, 397, 917-931. [Google Scholar] [CrossRef] [PubMed]
[22] Oehler, N., Volz, T., Bhadra, O.D., et al. (2014) Binding of Hepati-tis B Virus to Its Cellular Receptor Alters the Expression Profile of Genes of Bile Acid Metabolism. Hepatology, 60, 1483-1493. [Google Scholar] [CrossRef] [PubMed]
[23] Lin, Y.L., Shiao, M.S., Mettling, C., et al. (2003) Cholesterol Requirement of Hepatitis B Surface Antigen (HBsAg) Secretion. Virology, 314, 253-260. [Google Scholar] [CrossRef] 
[24] Okamura, H., Nio, Y., Akahori, Y., et al. (2016) Fatty Acid Biosynthesis Is Involved in the Production of Hepatitis B Virus Particles. Biochemical and Biophysical Research Com-munications, 475, 87-92. [Google Scholar] [CrossRef] [PubMed]
[25] Joo, E.J., Chang, Y., Yeom, J.S. and Ryu, S. (2017) Hepatitis B Virus Infection and Decreased Risk of Nonalcoholic Fatty Liver Disease: A Cohort Study. Hepatology, 65, 828-835. [Google Scholar] [CrossRef] [PubMed]
[26] Zhong, G.C., Wu, Y.L., Hao, F.B., et al. (2018) Current but Not Past Hep-atitis B Virus Infection Is Associated with a Decreased Risk of Nonalcoholic Fatty Liver Disease in the Chinese Popula-tion: A Case-Control Study with Propensity Score Analysis. Journal of Viral Hepatitis, 25, 842-852. [Google Scholar] [CrossRef] [PubMed]
[27] Razi, B., Alizadeh, S., Omidkhoda, A., et al. (2017) Association of Chronic Hepatitis B Infection with Metabolic Syndrome and Its Components: Meta-Analysis of Observational Studies. Diabetol-ogy & Metabolic Syndrome, 11, S939-S947. [Google Scholar] [CrossRef] [PubMed]
[28] Tseng, C.H., Muo, C.H., Hsu, C., et al. (2016) Association of Hep-atitis B Virus Infection with Decreased Ischemic Stroke. Acta Neurologica Scandinavica, 134, 339-345. [Google Scholar] [CrossRef] [PubMed]
[29] Sung, J., Song, Y.M., Choi, Y.H., et al. (2007) Hepatitis B Virus Seroposi-tivity and the Risk of Stroke and Myocardial Infarction. Stroke, 38, 1436-1441. [Google Scholar] [CrossRef] 
[30] Liu, P.T., Hwang, A.C. and Chen, J.D. (2013) Combined Effects of Hepatitis B Virus Infection and Elevated Alanine Aminotransferase Levels on Dyslipidemia. Metabolism, 62, 220-225. [Google Scholar] [CrossRef] [PubMed]
[31] Wong, V.W., Wong, G.L., Chu, W.C., et al. (2012) Hepatitis B Virus Infection and Fatty Liver in the General Population. Journal of Hepatology, 56, 533-540. [Google Scholar] [CrossRef] [PubMed]
[32] Peleg, N., Issachar, A., Sneh Arbib, O., et al. (2019) Liver Steato-sis Is a Strong Predictor of Mortality and Cancer in Chronic Hepatitis B Regardless of Viral Load. JHEP Reports, 1, 9-16. [Google Scholar] [CrossRef] [PubMed]
[33] Chan, A.W., Wong, G.L., Chan, H.Y., et al. (2017) Concurrent Fatty Liver Increases Risk of Hepatocellular Carcinoma among Patients with Chronic Hepatitis B. Journal of Gastroen-terology and Hepatology, 32, 667-676. [Google Scholar] [CrossRef] [PubMed]
[34] Lee, Y.B., Ha, Y., Chon, Y.E., et al. (2019) Association between Hepatic Steatosis and the Development of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B. Clinical and Molecular Hepatology, 25, 52-64. [Google Scholar] [CrossRef] [PubMed]
[35] van Kleef, L.A., Choi, H., Brouwer, W.P., et al. (2021) Metabolic Dysfunction-Associated Fatty Liver Disease Increases Risk of Adverse Outcomes in Patients with Chronic Hepatitis B. JHEP Reports, 3, Article ID: 100350. [Google Scholar] [CrossRef] [PubMed]
[36] Vilar-Gomez, E., Martinez-Perez, Y., Calzadilla-Bertot, L., et al. (2015) Weight Loss through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis. Gas-troenterology, 149, 367-378.e5. [Google Scholar] [CrossRef] [PubMed]

为你推荐