基于数据挖掘技术探索鲁艳芳治疗小儿汗病遣方用药规律

Study on Medication Rules of Lu Yanfang in Treatment of Hyperhidrosis in Children Based on Data Mining

摘要: 目的：选用数据挖掘方法探索鲁艳芳教授治疗儿童汗病的用药经验，为中医药治疗小儿汗病的临床及科研方面提供一定的参考依据。方法：收集、整理、筛选鲁艳芳教授2017年1月至2021年9月于湖北中医药大学第一附属医院门诊部治疗小儿汗病的病例，于中医传承计算平台建立数据库并采用四气统计、五味统计、归经统计、功效统计、药物频次、关联规则、聚类分析等分析方法对使用药物进行研究分析；并对基础方剂进行频次、关联规则、聚类分析。结果：共收集方剂237首，涉及中药198味，基础方剂36个。高频药物为：浮小麦、炙甘草、黄芪、陈皮、鸡内金、白茅根、当归、白芍、黄柏、青皮、生白术、五味子、辛夷、生地黄、桂枝等；药物四气以温为主；五味喜用甘，归经以肺经为主，脾经、胃经次之，功效则以补虚、清热类为主；并获得黄芪–浮小麦等多组核心药物组合。高频基础方剂为当归补血汤、当归六黄汤、桂枝汤等。结论：鲁艳芳教授治疗小儿汗病以调和营卫、健脾补肺、益气养阴、消积化热为主，兼以收涩敛汗。本研究得出的用药规律与鲁艳芳教授临床经验相符，可为临床治疗小儿汗病提供参考。

Abstract: objective: To investigate the experience in treatment and medication rules of Professor Lu Yan-fang for the treatment of hyperhidrosis in children based on data mining and provide some references for clinical treatment and scientific research of TCM treatment of hyperhidrosis in children. Methods: Medical cases diagnosed as hyperhidrosis in children by Professor Lu Yanfang from January 2017 to September 2021 in the Department of the First Affiliated Hospital of Hubei University of Chinese Medicine were collected, arranged and screened. The database was established on the TCM inheritance computing platform, and analyzed the used Chinese medicine by using four qi statistics, five taste statistics, attribution statistics, efficacy statistics, drug frequency, association rules, and cluster analysis. Frequency, association rules, and cluster analysis were also performed on the basic prescriptions. Results: Totally 237 prescriptions consisted of 198 kinds of Chinese materia medica and 36 basic formulas. High-frequency drugs are: Fuxiaomai, Zhigancao, Huangqi, Chenpi, Jineijin, Baimaogen, Danggui, Baishao, Huangbo, Qingpi, Shengbaizhu, Wuweizi, Xinyi, Shengdihuang, Guizhi, etc. Four qi is mainly warm; five-flavor is mainly sweet; the meridian is mainly the lung meridian, spleen meridian, and stomach meridian is the second and third; the effect is based to fill deficiency, clear heat class mainly. Several groups of core drug combinations such as Huangqi-Fuxiaomai were also obtained. High-frequency basic prescriptions are Dangguibuxue soup, Dangguiliuhuang soup, Guizhi soup, etc. Conclusion: Professor Lu Yanfang in the treatment of hyperhidrosis in children is mainly to Tiaoheyingwei, invigorating the splenic and lung, nourishing Qi and Yin, reducing the accumulated heat, and also collecting astringent sweat. The medication rule obtained in this study is consistent with the clinical experience of Professor Lu Yanfang, which can provide a reference for the clinical treatment of hidrosis in children.