亚硝酸盐中毒迟发性脑病二例分析

Analysis of Two Cases of Delayed Encephalopathy Caused by Nitrite Poisoning

摘要: 迟发性脑病(delayed encephalopathy)又称迟发性神经系统后遗症(delayed neurological sequelae, DNS)，是一种延迟出现的，以认知、精神、意识障碍、锥体系或锥体外系、大脑皮层局灶性神经损害为主要表现的脑功能障碍，临床上多见于急性一氧化碳中毒后的2天到2月内，这段时期又称为“假愈期”。急性亚硝酸盐中毒是急诊科常见的中毒性疾病，但亚硝酸盐中毒合并迟发性脑病的病例报道并不多见。本文通过济宁医学院附属医院诊治的两例重度急性亚硝酸盐中毒合并迟发性脑病患者的病例分析，进一步讨论亚硝酸盐中毒迟发性脑病的发生机制及预防措施。

Abstract: Delayed encephalopathy, also known as delayed neurological sequelae (DNS), is a kind of delayed onset, brain dysfunction characterized by cognitive, mental and consciousness disorders, cone sys-tem or extrapyramidal system, and focal nerve damage in the cerebral cortex, and is commonly seen in the first 2 days to 2 months after acute carbon monoxide poisoning. This period is also known as the “false recovery period”. Acute nitrite poisoning is a common toxic disease in the emergency department, but the case reports of nitrite poisoning complicated with delayed enceph-alopathy are rare. Through the analysis of two cases of severe acute nitrite poisoning complicated with delayed encephalopathy in the Affiliated Hospital of Jining Medical University, this paper fur-ther discusses the occurrence mechanism and preventive measures of delayed encephalopathy caused by nitrite poisoning.