肿瘤微环境在胰腺癌发病机制中的研究进展
Research Progress of Tumor Microenvironment in the Pathogenesis of Pancreatic Cancer
DOI: 10.12677/ACM.2022.12111530, PDF,    科研立项经费支持
作者: 段耀强：大理大学临床医学院，云南 大理；谭云波, 金礼权*：大理大学第一附属医院普外一科，云南 大理
关键词: 炎性因子；胰腺肿瘤；肿瘤微环境；发病机制；肠道微生态；Inflammatory Factors； Pancreatic Tumor； Tumor Microenvironment； Pathogenesis； Intestinal Microecology
摘要: 胰腺癌是世界上致死率最高的恶性肿瘤之一，其特点是发现晚、治疗难、预后差，经手术切除及放化疗等辅助治疗后的胰腺癌患者5年生存率仍低于5%。到目前为止胰腺癌发病机理尚不明确，且早期的临床症状和诊断缺乏特异性，但在各种恶性肿瘤中，肿瘤微环境起着很重要的作用。本文中，我们将从多个方面描述肿瘤微环境在胰腺癌发病机制中的作用，包括肿瘤相关炎症因子及肠道微生物等多个方面阐述胰腺癌的发病机制进行综述。
Abstract: Pancreatic cancer is one of the malignant tumors with the highest mortality rate in the world. It is characterized by late detection, difficult treatment and poor prognosis. The 5-year survival rate of pancreatic cancer patients after adjuvant treatment such as surgery, radiotherapy and chemo-therapy is still less than 5%. Up to now, the pathogenesis of pancreatic cancer is still unclear, and the early clinical symptoms and diagnosis are lack of specificity. However, tumor microenvironment plays an important role in various malignant tumors. In this article, we will describe the role of tu-mor microenvironment in the pathogenesis of pancreatic cancer from many aspects, including tu-mor related inflammatory factors and intestinal microbes, and review the pathogenesis of pancre-atic cancer.
文章引用：段耀强, 谭云波, 金礼权. 肿瘤微环境在胰腺癌发病机制中的研究进展[J]. 临床医学进展, 2022, 12(11): 10625-10630. https://doi.org/10.12677/ACM.2022.12111530

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