NICU新生儿红细胞输注次数的影响因素分析

Analysis of Influencing Factors on the Number of Red Blood Cell Transfusions in NICU Neonates

摘要: 目的：探究NICU婴儿输红细胞(RBC)的影响因素，为临床诊治提供参考。方法：收集2019年1月~2020年5月NICU输RBC婴儿的病历资料，分析婴儿输RBC的因素。结果：2组在胎龄、是否有败血症、是否产房复苏、是否用激素、是否用PS、是否用特殊抗生素、是否有创操作、住院时间、首次输RBC时间、性别、体重、身长、孕母是否妊高症、入院时血清乳酸值、入院时动脉血氧饱和度的比较，差异有统计学意义(P < 0.05)；二元logistic回归分析示败血症、用糖皮质激素、用特殊抗生素、住院 > 30天、首次输RBC时间 > 10天均影响输RBC次数，且首次输RBC时间 > 10天是保护因素(OR 0.006, P < 0.05)；败血症、用糖皮质激素、用特殊抗生素、住院 > 30天是独立危险因素(OR分别为13.354、7.381、5.258、1.086，P均 < 0.05)。结论：败血症、用糖皮质激素、用特殊抗生素、住院 > 30天、首次输RBC时间 > 10天均影响输RBC次数，且首次输RBC时间 > 10天是保护因素。

Abstract: Objective: To explore the influencing factors of red blood cell (RBC) transfusion in NICU infants, and to provide reference for clinical diagnosis and treatment. Methods: The medical records of infants who received RBC in NICU from January 2019 to May 2020 were collected, and the factors of infant RBC infusion were analyzed. Results: There were significant differences between the two groups in gestational age, whether there was sepsis, whether the delivery room was resuscitated, whether hormone was used, whether PS was used, whether special antibiotics were used, whether invasive procedures were used, length of stay, time of first RBC transfusion, gender, weight, length, whether the pregnant mother had pregnancy induced hypertension, serum lactate value at admission, arte-rial oxygen saturation at admission (P < 0.05); Binary logistic regression analysis showed that the number of RBC transfusions was affected by sepsis, glucocorticoid, special antibiotics, hospitaliza-tion > 30 days, and the first RBC transfusion time > 10 days, and the first RBC transfusion time > 10 days was a protective factor (OR 0.006, P < 0.05); Sepsis, glucocorticoid, special antibiotics and hos-pitalization > 30 days were independent risk factors (OR 13.354, 7.381, 5.258 and 1.086, respec-tively, P < 0.05). Conclusion: Sepsis, glucocorticoids, special antibiotics, hospitalization for >30 days, and the first RBC infusion time > 10 days all affect the number of RBC infusions, and the first RBC infusion time > 10 days is a protective factor.