百合地黄汤的研究现状及研究热点可视化分析

Visualized Analysis of Research Trends and Hotspots of Lilii and Rehmanniae Decoction

摘要: 目的：通过对文献计量学可视化分析，探讨百合地黄汤的研究现状及研究热点。方法：检索CNKI、CNKI引文数据库、万方数据库、维普数据库和PubMed英文文献数据库自数据库建立至2021年12月31日收录的以百合地黄汤为主题的相关文献，基于中文多库融合数据进行年度发文量统计，并采用CiteSpace软件对其作者、机构、关键词等进行可视化分析，基于聚类分析和突显词分析探讨研究趋势和研究热点。结果：共纳入中文文献683篇，英文文献6篇。发文量总体呈波折上升趋势，广州中医药大学全世建是被引频次最高的作者，受基金资助的论文占11.52%，其中受国家自然科学基金资助最多(3.66%)。中文文献的关键词主要包括百合病、失眠(不寐/失眠症/睡眠障碍)、抑郁症、临床应用/临床经验、名医经验等，其研究热点集中在基础理论、临床应用研究(以抑郁为主，其次是失眠及更年期综合征)。英文文献研究均为百合地黄汤治疗抑郁症的机制研究。结论：百合地黄汤年发文量较少，近年来以临床应用研究为主，作为经典名方其成药的开发利用可能成为未来的研究趋势。

Abstract: Objective: To analyze the development tendency and research hotspot of lilii and rehmanniae decoction based on bibliometric method. Methods: Five databases, i.e., China National Knowledge Infrastructure (CNKI), CNKI Chinese citation database, VIP, Wanfang Data and PubMed, were searched for lilii and rehmanniae decoction published from database inception to December 31th 2021. CiteSpace was used to visualize and construct networks based on co-authorship and co-institutions, co-occurrence of keywords, and Cluster analysis and burst rate showed the decoction’s research trends and hotspots. Results: A total of 683 Chinese literatures and 6 English literatures were retrieved. The literature analysis shows that Shijian Quan from Guangzhou University of Traditional Chinese Medicine was the author with the highest citation frequency, the citation rate of the total funded papers was 11.52%, and the papers supported by National Natural Science Foundation of China has the highest citation frequency 3.66%. The keywords of Chinese literatures were ranked as bulbus lilii syndrome, insomnia, depressive disorder, clinical application, experience of famous docto, etc., the hotspots included basic theory and clinical application (the most common disease was depression, and then insomnia and climacteric syndrome), and that of English literatures were all therapeutic mechanisms of lilii and rehmanniae decoction in the treatment of depression. Conclusion: The annual publication volume of lilii and rehmanniae decoction was fluctuating and increasing, Clinical application was the main study, and developing the patent Medicine of the famous classical formula will be the future trends.