代谢相关脂肪性肝病非药物干预及中药治疗进展
Progress of Non-Drug Intervention and Traditional Chinese Medicine Treatment of Metabolic-Associated with Fatty Liver Disease
DOI: 10.12677/ACM.2022.12111573, PDF,    科研立项经费支持
作者: 曾 林:湖南省代谢相关脂肪性肝病临床研究中心,南华大学衡阳医学院附属南华医院,湖南 衡阳;南华大学衡阳医学院附属南华医院重症医学科,湖南 衡阳;林海连, 阳学风*:湖南省代谢相关脂肪性肝病临床研究中心,南华大学衡阳医学院附属南华医院,湖南 衡阳;南华大学衡阳医学院附属南华医院消化内科,湖南 衡阳;万东梅*:湖南省代谢相关脂肪性肝病临床研究中心,南华大学衡阳医学院附属南华医院,湖南 衡阳;南华大学衡阳医学院附属南华医院创伤骨科,湖南 衡阳
关键词: 代谢相关脂肪性肝病膳食干预运动干预针灸理疗中药Metabolic-Associated with Fatty Liver Disease Dietary Intervention Exercise Intervention Acupuncture and Physical Therapy Chinese Medicine Treatment
摘要: 代谢相关脂肪性肝病(Metabolic-associated with fatty liver disease, MAFLD),目前已成为我国居民第一大肝脏疾病,也是全球最常见的慢性肝病。发病常与肥胖、糖尿病及生活不良习惯有关。目前MAFLD常缺乏有效的治疗药物。很幸运的是,大多数MAFLD如处于单纯性脂肪肝阶段不需要药物治疗,通过非药物干预治疗即可逆转单纯性脂肪肝,阻止脂肪肝进一步发展。目前,有关非药物干预治疗主要包括膳食干预、运动干预、针灸理疗、穴位埋线等方式。本文就MAFLD非药物干预及中药治疗进展综述如下。
Abstract: Metabolic-associated with fatty liver disease (MAFLD) has become the most common liver disease in China and the most common chronic liver disease in the world. The disease is often associated with obesity, diabetes and bad living habits. At present, there is a lack of effective drugs to treat MAFLD. Fortunately, most MAFLD patients in the stage of simple fatty liver disease do not require drug therapy. Non-drug intervention can reverse simple fatty liver disease and prevent further devel-opment of simple fatty liver disease. At present, the relevant non-drug intervention therapy mainly includes dietary intervention, exercise intervention, acupuncture therapy, acupuncture point cat-gut and so on. In this paper, the progress of non-drug intervention and traditional Chinese medicine treatment for MAFLD is summarized as follows.
文章引用:曾林, 林海连, 阳学风, 万东梅. 代谢相关脂肪性肝病非药物干预及中药治疗进展[J]. 临床医学进展, 2022, 12(11): 10927-10932. https://doi.org/10.12677/ACM.2022.12111573

参考文献

[1] Younossi, Z.M., Koenig, A.B., Abdelatif, D., Fazel, Y., Henry, L. and Wymer, M. (2016) Global Epidemiology of Non-alcoholic Fatty Liver Disease—Meta-Analytic Assessment of Prevalence, Incidence, and Outcomes. Hepatology, 4, 73-84. [Google Scholar] [CrossRef] [PubMed]
[2] Fouad, Y., Waked, I., Bollipo, S., Gomaa, A., Ajlouni, Y. and Attia, D. (2020) What’s in a Name? Renaming ‘NAFLD’ to ‘MAFLD’. Liver International, 40, 1254-1261. [Google Scholar] [CrossRef] [PubMed]
[3] Fujii, H., Kawada, N. and Japan Study Group of Nafld (JSG-NAFLD) (2020) The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease. International Journal of Molec-ular Sciences, 21, Article No. 3863. [Google Scholar] [CrossRef] [PubMed]
[4] Leung, J.C., Loong, T.C., Wei, J.L., Wong, G.L., Chan, A.W., Choi, P.C., Shu, S.S., Chim, A.M., Chan, H.L. and Wong, V.W. (2017) Histological Severity and Clinical Outcomes of Non-alcoholic Fatty Liver Disease in Nonobese Patients. Hepatology, 65, 54-64. [Google Scholar] [CrossRef] [PubMed]
[5] Golabi, P., Rhea, L., Henry, L. and Younossi, Z.M. (2019) Hepatocellular Carcinoma and Non-Alcoholic Fatty Liver Disease. Hepatology International, 13, 688-694. [Google Scholar] [CrossRef] [PubMed]
[6] Prasoppokakorn, T., Pitisuttithum, P. and Treeprasertsuk, S. (2021) Pharmacological Therapeutics: Current Trends for Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD). Journal of Clinical and Translational Hepatology, 9, 939-946. [Google Scholar] [CrossRef
[7] Lazarus, J.V., Ekstedt, M., Marchesini, G., Mullen, J., Novak, K., Pericàs, J.M., Roel, E., Romero-Gómez, M., Ratziu, V., Tacke, F., Cortez-Pinto, H. and Anstee, Q.M. (2020) A Cross-Sectional Study of the Public Health Response to Non-Alcoholic Fatty Liver Disease in Europe. Journal of Hepa-tology, 72, 14-24. [Google Scholar] [CrossRef] [PubMed]
[8] Fan, J.G., Kim, S.U. and Wong, V.W. (2017) New Trends on Obesity and NAFLD in Asia. Journal of Hepatology, 67, 862-873. [Google Scholar] [CrossRef] [PubMed]
[9] Lazo, M., Hernaez, R., Eberhardt, M.S., Bonekamp, S., Kamel, I., Guallar, E., Koteish, A., Brancati, F.L. and Clark, J.M. (2013) Prevalence of Nonalcoholic Fatty Liver Disease in the United States: The Third National Health and Nutrition Examination Survey, 1988-1994. American Journal of Epidemi-ology, 178, 38-45. [Google Scholar] [CrossRef] [PubMed]
[10] Lonardo, A., Byrne, C.D., Caldwell, S.H., Cortez-Pinto, H. and Targher, G. (2016) Global Epidemiology of Nonalcoholic Fatty Liver Disease: Meta-Analytic Assessment of Prevalence, Inci-dence, and Outcomes. Hepatology, 64, 1388-1389. [Google Scholar] [CrossRef] [PubMed]
[11] Li, J., Zou, B., Yeo, Y.H., Feng, Y., Xie, X., Lee, D.H., Fujii, H., Wu, Y., Kam, L.Y., Ji, F., Li, X., Chien, N., Wei, M., Ogawa, E., Zhao, C., Wu, X., Stave, C.D., Henry, L., Barnett, S., Takahashi, H., Furusyo, N., Eguchi, Y., Hsu, Y.C., Lee, T.Y., Ren, W., Qin, C., Jun, D.W., Toyoda, H., Wong, V.W. and Cheung, R. (2019) Prevalence, Incidence, and Outcome of Non-Alcoholic Fatty Liver Disease in Asia, 1999-2019: A Systematic Review and Meta-Analysis. The Lancet Gastroenterology and Hepatology, 4, 389-398. [Google Scholar] [CrossRef
[12] Cohen, J.C., Horton, J.D. and Hobbs, H.H. (2011) Human Fatty Liver Disease: Old Questions and New Insights. Science, 332, 1519-1523. [Google Scholar] [CrossRef] [PubMed]
[13] Hall, K.D. and Guo, J. (2017) Obesity Energetics: Body Weight Reg-ulation and the Effects of Diet Composition. Gastroenterology, 152, 1718-1727. [Google Scholar] [CrossRef] [PubMed]
[14] 孙平. 代谢相关脂肪性肝病膳食干预的前瞻性研究[D]: [硕士学位论文]. 成都: 电子科技大学, 2021.
[15] Gao, C., Xu, J., Liu, Y. and Yang, Y. (2021) Nutrition Policy and Healthy China 2030 Building. European Journal of Clinical Nutrition, 75, 238-246. [Google Scholar] [CrossRef] [PubMed]
[16] 中国医疗保健国际交流促进会营养与代谢管理分会, 中国营养学会临床营养分会, 中华医学会糖尿病学分会, 中华医学会肠外肠内营养学分会, 中国医师协会营养医师专业委员会. 中国糖尿病医学营养治疗指南(2022版) [J]. 中华糖尿病杂志, 2022, 14(9): 881-933.
[17] 中国研究型医院学会肝病专业委员会, 中国医师协会脂肪性肝病专家委员会, 中华医学会肝病学分会脂肪肝与酒精性肝病学组, 中华医学会内分泌学分会肝病与代谢学组. 脂肪性肝病诊疗规范化的专家建议(2019年修订版) [J]. 实用肝脏病杂志, 2019, 22(6): 787-792.
[18] 胡鑫才, 黄小冬. 基于现代文献的针灸治疗非酒精性脂肪肝选穴规律研究[J]. 中医临床研究, 2019, 11(31): 7-11.
[19] 崔滋欣, 潘甜甜, 李佳韵, 魏佩瑶, 叶峰. 针灸治疗非酒精性脂肪性肝病临床疗效Meta分析[J]. 中国肝脏病杂志(电子版), 2021, 13(1): 10-16.
[20] 钟培玲, 刘林华, 贺劲松. 针灸治疗非酒精性脂肪性肝病的研究进展[J]. 广州中医药大学学报, 2022, 39(3): 727-734.
[21] 谢文强. 穴位埋线治疗重度非酒精性脂肪肝患者的临床疗效观察[J]. 江西中医药大学学报, 2022, 34(4): 64-66.
[22] 李永丰, 谢冬梅, 姚立红, 麻飞玲. 穴位微创埋线治疗非酒精性脂肪性肝病的临床研究[J]. 中西医结合肝病杂志, 2019, 29(6): 550-551+558.
[23] 高思婷, 冯琴. 非酒精性脂肪肝的中医特色疗法——穴位埋线[J]. 肝博士, 2022(5): 49-50.
[24] 李军祥, 陈润花, 苏冬梅, 李立. 中医药治疗非酒精性脂肪性肝病研究述评[J]. 世界华人消化杂志, 2010, 18(14): 1443-1451.
[25] 朱雅娜, 孙玉凤, 何莉莉, 等. 活血化瘀通络中药合方及拆方对糖尿病脂肪肝大鼠SOCS-3和SREBP-1c的影响[J]. 世界华人消化杂志, 2013, 21(29): 3089-3096.
[26] 刘永萍, 杨如意. 中西医结合治疗高脂血症脂肪肝疗效观察研究[J]. 心理月刊, 2018(3): 193.
[27] 史俊玲, 李风娥, 刘玉洁. 泽泻方剂抗家兔动脉粥样硬化形成的实验研究[J]. 河北中医, 2008, 30(5): 530-532.
[28] 赵宏, 谢晓玲, 万金志. 山药的化学成分及药理研究进展[J]. 今日药学, 2009, 19(3): 49-50.
[29] 李志强, 曹文富. 山药及其主要活性成分药理作用研究进展[J]. 中国老年学杂志, 2013, 33(8): 1975-1976.
[30] 郭建利, 张睦清, 韩雪, 等. 丹参不同组分防治大鼠非酒精性脂肪肝模型作用机制的研究[J]. 河北中医药学报, 2012, 27(1): 8-9.
[31] 古宁艳, 杨少军. 中医药防治脂肪肝实验研究进展[J]. 中国中医药信息杂志, 2012, 19(4): 111-112.
[32] 刘超, 张学武. 黄芪对高脂血症小鼠血脂及脂质过氧化物的影响[J]. 时珍国医国药, 2007, 18(7): 1648-1649.
[33] 陈莉, 何立英, 金鑫. 麦冬多糖对脂肪细胞胰岛素敏感性的作用机制[J]. 武警后勤学院学报, 2013, 22(1): 5-8.
[34] 季光. 中医药治疗非酒精性脂肪性肝病敲响国际学术大门[J]. 中西医结合肝病杂志, 2021, 31(6): 484-488.