2型糖尿病合并高尿酸血症患者尿酸排泄分数与代谢指标的相关分析

Correlation Analysis of Uric Acid Excretion Fraction and Metabolic Indices in Type 2 Diabetes Patients with Hyperuricemia

摘要: 目的：探究2型糖尿病合并高尿酸血症(HUA)的患者中尿酸排泄分数(FEUA)与各代谢指标的相关性分析。方法：选取本院2021年9月至2022年1月内分泌科住院及门诊单纯高尿酸血症(HUA)及HUA合并2型糖尿病患者共233例，依据血尿酸及是否合并糖尿病分为单纯HUA组和HUA合并糖尿病(DM)组。观察2组患者的临床特征及FEUA与各代谢指标的相关性。结果：与单纯HUA组相比，HUA合并DM组的BMI、SCr、FPG、HbA1c显著升高，UCr、FEUA显著降低，差异有统计学意义(P < 0.05)。Pearson相关分析显示，FEUA与UCr (P < 0.001)、SUA (P = 0.034)成负相关，与HbA1c (P = 0.023)、FPG (P = 0.019)成正相关，(P < 0.05)有统计学意义。按FEUA结果分型，原发性HUA患者无论是否合并2型糖尿病均以尿酸排泄减少型为主，且两组HUA患者中尿酸排泄减少型、混合型、尿酸生成增多型的百分率比较均显示差异无统计学意义(P > 0.05)。结论：2型糖尿病合并HUA患者仍以尿酸排泄减少型为主，血糖升高影响尿酸排泄分数，对不同类型的糖尿病合并高尿酸患者应采取不同的治疗方式，积极预防糖尿病慢性并发症。

Abstract: Objective: To explore the correlation between uric acid excretion fraction (FEUA) and metabolic indicators in type 2 diabetes patients with hyperuricemia (HUA). Methods: A total of 233 inpatients with hyperuricemia (HUA) and hyperuricemia complicated with type 2 diabetes in the department of secretion and outpatient department from September 2021 to January 2022 were selected and divided into two groups according to blood uric acid and diabetes mellitus. The clinical characteristics and the correlation between FEUA and metabolic indexes in 2 groups were observed. Results: Compared with the HUA group alone, BMI, SCr, FPG and HbA1c in the HUA group combined with DM were significantly increased, while UCr and FEUA were significantly decreased, with statistical significance (P < 0.05). Pearson correlation analysis showed that FEUA was negatively correlated with UCr (P < 0.001) and SUA (P = 0.034), and positively correlated with HbA1c (P = 0.023) and FPG (P = 0.019). According to FEUA results, reduced uric acid excretion was the predominant type in primary HUA patients regardless of type 2 diabetes, and there was no statistical significance in the percentage of reduced uric acid excretion, mixed type and increased uric acid production between the two groups (P > 0.05). Conclusions: Reduced uric acid excretion is still the dominant type in type 2 diabetes patients with hyperuricemia, and elevated blood glucose affects the uric acid excretion fraction. Different treatment methods should be adopted for different types of diabetes patients with hyperuricemia to actively prevent chronic complications of diabetes.