促血小板生成素受体激动剂治疗骨髓增生异常综合征伴血小板减少一例并文献复习
One Case of Thrombopoietin Receptor Ago-nist in the Treatment of Myelodysplastic Syndrome with Thrombocytopenia and Literature Review
摘要: 目的:提供血小板生成素受体激动剂(Thrombopoietin receptor agonists, TPO-RA)治疗较低危骨髓增生异常综合征(Myelodysplastic syndromes, MDS)患者伴血小板减少的临床经验,提供更多治疗选择。方法:回顾1例应用TPO-RA的MDS伴血小板减少患者的临床资料,分析其临床特点并复习相关文献。结果:患者应用去甲基化及海曲泊帕治疗无效改用阿伐曲泊帕取得血小板反应。结论:对于既往TPO-RA治疗无效的MDS患者,TPO-RAs转换可能具有潜在价值。
Abstract: Objective: To summarize the clinical experience of TPO-RA in the treatment of lower-risk MDS pa-tients with thrombocytopenia, expanding treatment options. Methods: The clinical data of a patient with MDS and thrombocytopenia treated with TPO-RA were retrospectively analyzed, and the re-lated literature was reviewed. Results: The patient failed to respond to hypomethylating agent and herombopag and then received avatrombopag to achieve platelet response. Conclusion: For MDS patients ineffective with prior TPO-RA therapy, the TPO-RAs transformation may have potential value.
文章引用:张奇, 赵春亭. 促血小板生成素受体激动剂治疗骨髓增生异常综合征伴血小板减少一例并文献复习[J]. 临床医学进展, 2022, 12(12): 11001-11006. https://doi.org/10.12677/ACM.2022.12121584

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