成人非复杂性急性阑尾炎治疗进展
Progress in the Treatment of Uncomplicated Acute Appendicitis in Adults
摘要: 急性阑尾炎是由阑尾腔阻塞(主要包括淋巴结增生和粪石阻塞)后继发感染形成的疾病。近年来,随着相关随机对照试验的开展以及对阑尾炎治疗方式的不断探索,急性阑尾炎的治疗方式取得了一定的进展。阑尾切除术能够从根源切除病灶并杜绝阑尾肿瘤的发生,但术后并发症较多。单用抗生素治疗能明显缩短住院时间,减少并发症并且成本较低,但有一定的失败率及较高的复发率。内镜逆行阑尾炎治疗属于微创手术,与阑尾切除术一样能立即缓解腹痛,有着极高的治疗成功率,极低的复发率及并发症发生率。在此,我们将对非复杂性急性阑尾炎的治疗方式进行介绍与讨论,以期为临床决策提供一定的参考。
Abstract: Acute appendicitis is a disease caused by secondary infection after obstruction of the appendiceal cavity, mainly including lymph node hyperplasia and obstruction of the fecalith. In recent years, with the development of relevant randomized controlled trials and the continuous exploration of the treatment of appendicitis, the treatment of acute appendicitis has made some progress. Ap-pendectomy can remove the lesions from the root and prevent the occurrence of appendiceal tu-mors, but there are many postoperative complications. Antibiotic therapy alone can significantly shorten the length of hospital stay, reduce complications and cost less, but it has a certain failure rate and a high recurrence rate. Endoscopic retrograde appendicitis treatment is a minimally inva-sive surgery, which can relieve abdominal pain immediately as appendectomy. It has a high success rate of treatment and a very low recurrence rate and complication rate. In this article, we will in-troduce and discuss the treatment of uncomplicated acute appendicitis, in order to provide some reference for clinical decision-making.
文章引用:傅俊豪, 张浩. 成人非复杂性急性阑尾炎治疗进展[J]. 临床医学进展, 2022, 12(12): 11089-11095. https://doi.org/10.12677/ACM.2022.12121598

参考文献

[1] Livingston, E.H., Woodward, W.A., Sarosi, G.A. and Haley, R.W. (2007) Disconnect between Incidence of Nonperfo-rated and Perforated Appendicitis: Implications for Pathophysiology and Management. Annals of Surgery, 245, 886-892. [Google Scholar] [CrossRef] [PubMed]
[2] Vons, C., Barry, C., Maitre, S., et al. (2011) Amoxicillin plus Clavulanic Acid versus Appendicectomy for Treatment of Acute Uncomplicated Appendicitis: An Open-Label, Non-Inferiority, Randomised Controlled Trial. The Lancet, 377, 1573-1579. [Google Scholar] [CrossRef
[3] Ceresoli, M., Pisano, M., Allievi, N., et al. (2019) Never Put Equipoise in Appendix! Final Results of ASAA (Antibiotics vs. Surgery for Uncomplicated Acute Appendicitis in Adults) Randomized Controlled Trial. Updates in Surgery, 71, 381-387. [Google Scholar] [CrossRef] [PubMed]
[4] Salminen, P., Paajanen, H., Rautio, T., et al. (2015) Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 313, 2340-2348. [Google Scholar] [CrossRef] [PubMed]
[5] Moris, D., Paulson, E.K. and Pappas, T.N. (2021) Diagnosis and Management of Acute Appendicitis in Adults: A Review. JAMA, 326, 2299-2311. [Google Scholar] [CrossRef] [PubMed]
[6] Bhangu, A., Søreide, K., Di Saverio, S., Assarsson, J.H. and Drake, F.T. (2015) Acute Appendicitis: Modern Understanding of Pathogenesis, Diagnosis, and Management. The Lancet, 386, 1278-1287. [Google Scholar] [CrossRef
[7] Myers, E., Kavanagh, D.O., Ghous, H., Evoy, D. and McDermott, E.W. (2010) The Impact of Evolving Management Strategies on Negative Appendicectomy Rate. Colorectal Disease: The Official Journal of the Association of Coloproctology of Great Britain and Ireland, 12, 817-821. [Google Scholar] [CrossRef] [PubMed]
[8] Seetahal, S.A., Bolorunduro, O.B., Sookdeo, T.C., Oyetunji, T.A., et al. (2010) Negative Appendectomy: A 10-Year Review of a Nationally Representative Sample. The American Journal of Surgery, 201, 433-437. [Google Scholar] [CrossRef] [PubMed]
[9] Lu, C., Liu, C., Fuh, J., et al. (2007) Irritable Bowel Syndrome and Negative Appendectomy: A Prospective Multivariable Investigation. Gut, 56, 655-660. [Google Scholar] [CrossRef] [PubMed]
[10] Renteria, O., Shahid, Z. and Huerta, S. (2018) Outcomes of Appen-dectomy in Elderly Veteran Patients. Surgery, 164, 460-465. [Google Scholar] [CrossRef] [PubMed]
[11] Kwan, H.T.L. (2010) Re: If Not Appendicitis, Then What Else Can It Be? A Retrospective Review of 1492 Appendectomies. Hong Kong Medical Journal, 16, 12-17.
[12] Slim, C., Ahmad, S., Abdellatif, A., et al. (2014) Histopathological Find-ings in Appendectomy Specimens: A Study of 24,697 Cases. International Journal of Colorectal Disease, 29, 1009-1012. [Google Scholar] [CrossRef] [PubMed]
[13] Masahata, K., Umemoto, E., Kayama, H., et al. (2014) Generation of Colonic IgA-Secreting Cells in the Caecal Patch. Nature Communications, 5, Article No. 3704. [Google Scholar] [CrossRef] [PubMed]
[14] Randal, B.R., Barbas, A.S., Bush, E.L., et al. (2007) Biofilms in the Large Bowel Suggest an Apparent Function of the Human Vermiform Appendix. Journal of Theoretical Biology, 249, 826-831. [Google Scholar] [CrossRef] [PubMed]
[15] Meng, W., Cai, S.-R., Zhou, L., Dong, Q., Zheng, S. and Zhang, S.-Z. (2009) Performance Value of High Risk Factors in Colorectal Cancer Screening in China. World Journal of Gastroenterology, 15, 6111-6116. [Google Scholar] [CrossRef] [PubMed]
[16] Andersson, R.E., Olaison, G., Tysk, C., et al. (2003) Appendectomy Is Followed by Increased Risk of Crohn’s Disease. Gastroenterology, 124, 40-46. [Google Scholar] [CrossRef] [PubMed]
[17] Jaschinski, T., Mosch, C., Eikermann, M. and Neugebauer, E.A.M. (2015) Laparoscopic versus Open Appendectomy in Patients with Suspected Appendicitis: A Systematic Review of Me-ta-Analyses of Randomised Controlled Trials. BMC Gastroenterology, 15, Article No. 48. [Google Scholar] [CrossRef] [PubMed]
[18] Yu, M.-C., Feng, Y.-J., Wang, W., et al. (2017) Is Laparoscopic Appendectomy Feasible for Complicated Appendicitis? A Systematic Review and Meta-Analysis. International Journal of Surgery, 40, 187-197. [Google Scholar] [CrossRef] [PubMed]
[19] Nakhamiyayev, V., Galldin, L., Chiarello, M., Lumba, A. and Gorecki, P.J. (2010) Laparoscopic Appendectomy Is the Preferred Approach for Appendicitis: A Retrospective Review of Two Practice Patterns. Surgical Endoscopy, 24, 859-864. [Google Scholar] [CrossRef] [PubMed]
[20] Di Saverio, S., Podda, M., De Simone, B., et al. (2020) Diagnosis and Treatment of Acute Appendicitis: 2020 Update of the WSES Jerusalem Guidelines. World Journal of Emergency Surgery: WJES, 15, 27. [Google Scholar] [CrossRef] [PubMed]
[21] Xue, C.R., Lin, B.Q., Huang, Z.Y. and Chen, Z. (2015) Sin-gle-Incision Laparoscopic Appendectomy versus Conventional 3-Port Laparoscopic Appendectomy for Appendicitis: An Updated Meta-Analysis of Randomized Controlled Trials. Surgery Today, 45, 1179-1186. [Google Scholar] [CrossRef] [PubMed]
[22] Carter, J.T., Kaplan, J.A., Nguyen, J.N., et al. (2014) A Prospec-tive, Randomized Controlled Trial of Single-Incision Laparoscopic vs Conventional 3-Port Laparoscopic Appendectomy for Treatment of Acute Appendicitis. Journal of the American College of Surgeons, 218, 950-959. [Google Scholar] [CrossRef] [PubMed]
[23] Wang, D.Y., Dong, T., Shao, Y., Gu, T.T., Xu, Y. and Jiang, Y. (2019) Laparoscopy versus Open Appendectomy for Elderly Patients, a Meta-Analysis and Systematic Review. BMC Surgery, 19, Article No. 54. [Google Scholar] [CrossRef] [PubMed]
[24] Kang, B.M., Choi, S.I., Kim, B.-S. and Lee, S.-H. (2018) Sin-gle-Port Laparoscopic Surgery in Uncomplicated Acute Appendicitis: A Randomized Controlled Trial. Surgical Endos-copy, 32, 3131-3137. [Google Scholar] [CrossRef] [PubMed]
[25] Swank, H.A., van Rossem, C.C., van Geloven, A.A.W., et al. (2014) Endostapler or Endoloops for Securing the Appendiceal Stump in Laparoscopic Appendectomy: A Retrospective Cohort Study. Surgical Endoscopy, 28, 576-583. [Google Scholar] [CrossRef] [PubMed]
[26] van Rossem, C.C., van Geloven, A.A.W., Schreinemacher Marc, H.F. and Bemelman, W.A. (2017) Endoloops or Endostapler Use in Laparoscopic Appendectomy for Acute Uncompli-cated and Complicated Appendicitis: No Difference in Infectious Complications. Surgical Endoscopy, 31, 178-184. [Google Scholar] [CrossRef] [PubMed]
[27] Qian, D.H., He, Z.G., Hua, J. and Song, Z.S. (2015) Stump In-vagination versus Simple Ligation in Open Appendicectomy: A Systematic Review and Meta-Analysis. International Surgery, 100, 1199-1206. [Google Scholar] [CrossRef
[28] van Dijk, S.T., van Dijk, A.H., Dijkgraaf, M.G. and Boermeester, M.A. (2018) Meta-Analysis of In-Hospital Delay before Surgery as a Risk Factor for Complications in Pa-tients with Acute Appendicitis. The British Journal of Surgery, 105, 933-945. [Google Scholar] [CrossRef] [PubMed]
[29] 王海宽, 李世宽, 李元博, 刘静, 窦榕榕, 渠雪红. 成人急性阑尾炎脓液的细菌培养及药敏试验[J]. 青岛大学医学院学报, 2011, 47(3): 255-257.
[30] Kalligeros, M. and Mylonakis, E. (2019) In Uncomplicated Acute Appendicitis, 61% of Patients Initially Treated with Antibiotics Had Not Had Appendectomy at 5 Years. Annals of Internal Medicine, 170, JC10. [Google Scholar] [CrossRef
[31] Salminen, P., Paajanen, H., Rautio, T., et al. (2015) Antibi-otic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 313, 2340-2348. [Google Scholar] [CrossRef] [PubMed]
[32] Paulina, S., Risto, T., Hannu, P., et al. (2018) Five-Year Follow-Up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. JAMA, 320, 1259-1265. [Google Scholar] [CrossRef] [PubMed]
[33] Lo Vecchio, F. (2021) A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis. New England Journal of Medicine, 384, 879-881. [Google Scholar] [CrossRef
[34] Simillis, C., Symeonides, P., Shorthouse, A.J. and Tekkis, P.P. (2009) A Meta-Analysis Comparing Conservative Treatment versus Acute Appendectomy for Complicated Appendicitis (Ab-scess or Phlegmon). Surgery, 147, 818-829. [Google Scholar] [CrossRef] [PubMed]
[35] Sippola, S., Grönroos, J., Tuominen, R., et al. (2017) Economic Evaluation of Antibiotic Therapy versus Appendicectomy for the Treatment of Uncomplicated Acute Appendicitis from the APPAC Randomized Clinical Trial. The British Journal of Surgery, 104, 1355-1361. [Google Scholar] [CrossRef] [PubMed]
[36] Di Saverio, S., Sibilio, A., Giorgini, E., et al. (2014) The NOTA Study (Non Operative Treatment for Acute Appendicitis): Prospective Study on the Efficacy and Safety of Antibiotics (Amoxi-cillin and Clavulanic Acid) for Treating Patients with Right Lower Quadrant Abdominal Pain and Long-Term Follow-Up of Conservatively Treated Suspected Appendicitis. Annals of Surgery, 260, 109-117. [Google Scholar] [CrossRef
[37] McCutcheon, B.A., Chang, D.C., Marcus, L.P., et al. (2014) Long-Term Outcomes of Patients with Nonsurgically Managed Uncomplicated Appendicitis. Journal of the American College of Surgeons, 218, 905-913. [Google Scholar] [CrossRef] [PubMed]
[38] Di Saverio, S., Birindelli, A., Kelly, M.D., et al. (2016) WSES Jerusalem Guidelines for Diagnosis and Treatment of Acute Appendicitis. World Journal of Emergency Surgery: WJES, 11, 34. [Google Scholar] [CrossRef] [PubMed]
[39] Loftus, T.J., Brakenridge, S.C., Croft, C.A., et al. (2018) Successful Nonoperative Management of Uncomplicated Appendicitis: Predictors and Outcomes. Journal of Sur-gical Research, 222, 212-218.e2. [Google Scholar] [CrossRef] [PubMed]
[40] Jussi, H., Suvi, S., Eliisa, L., et al. (2021) Factors Associated with Primary Nonresponsiveness to Antibiotics in Adults with Uncomplicated Acute Appendicitis: A Prespecified Secondary Analysis of a Randomized Clinical Trial. JAMA Surgery, 156, 1179-1181. [Google Scholar] [CrossRef] [PubMed]
[41] Liu, B.-R., Ma, X., Feng, J., et al. (2015) Endoscopic Retrograde Appendicitis Therapy (ERAT): A Multicenter Retrospective Study in China. Surgical Endoscopy, 29, 905-909. [Google Scholar] [CrossRef] [PubMed]
[42] Ding, W.J., Du, Z.Q. and Zhou, X.R. (2022) Endoscopic Retro-grade Appendicitis Therapy for Management of Acute Appendicitis. Surgical Endoscopy, 36, 2480-2487. [Google Scholar] [CrossRef] [PubMed]
[43] Yang, B.H., Kong, L.J., Saif, U., et al. (2022) Endoscopic Ret-rograde Appendicitis Therapy vs. Laparoscopic Appendectomy for Uncomplicated Acute Appendicitis. Endoscopy, 54, 747-754. [Google Scholar] [CrossRef] [PubMed]
[44] Yu, C.-W., Juan, L.-I., Wu, M.-H., Shen, C.-J., Wu, J.-Y. and Lee, C.-C. (2013) Systematic Review and Meta-Analysis of the Diagnostic Accuracy of Procalcitonin, C-Reactive Protein and White Blood Cell Count for Suspected Acute Appendicitis. The British Journal of Surgery, 100, 322-329. [Google Scholar] [CrossRef] [PubMed]
[45] Sippola, S., Virtanen, J., Tammilehto, V., et al. (2020) The Accuracy of Low-Dose Computed Tomography Protocol in Patients with Suspected Acute Appendicitis: The OPTICAP Study. An-nals of Surgery, 271, 332-338. [Google Scholar] [CrossRef