急性阑尾炎穿孔的影响因素分析
Analysis of Factors Influencing the Perforation of Acute Appendicitis
摘要: 急性阑尾炎是全球最常见的急腹症之一,治疗方式分为手术治疗和非手术治疗。而阑尾穿孔为阑尾炎发展的终末阶段,具有很大的风险,即使经过适当的治疗,其后果也会导致住院时间延长、发病率和死亡率增加。如果在穿孔发生前及时诊断,这种情况可以通过简单的手术来预防。穿孔性阑尾炎患者的处理与非穿孔性阑尾炎患者有很大不同,因此,术前鉴别穿孔性阑尾炎非常重要。本文回顾了相关文献并描述了白细胞、中性粒细胞、C反应蛋白、胆红素、纤维蛋白原、平均血小板体积。年龄等影响因素有助于判断阑尾穿孔发生的可能,改善预后。
Abstract: Acute appendicitis is one of the most common acute abdominal conditions worldwide, and treat-ment is divided into surgical and non-surgical options. Appendiceal perforation, however, is the end stage of appendicitis development and carries a high risk of consequences leading to prolonged hospitalization and increased morbidity and mortality, even after appropriate treatment. This con-dition can be prevented by simple surgery if diagnosed in time before perforation occurs. The management of patients with perforated appendicitis is very different from that of patients with nonperforated appendicitis; therefore, it is important to identify perforated appendicitis preopera-tively. This article reviews the relevant literature and describes leukocytes, neutrophils, C-reactive protein, bilirubin, fibrinogen, and mean platelet volume. Age and other influencing factors can help to determine the possibility of appendiceal perforation and improve the prognosis.
文章引用:吕卓航, 郑伟, 吴占庆. 急性阑尾炎穿孔的影响因素分析[J]. 临床医学进展, 2022, 12(12): 11096-11101. https://doi.org/10.12677/ACM.2022.12121599

参考文献

[1] Ferris, M., Quan, S., Kaplan, B.S., Molodecky, N., Ball, C.G., Chernoff, G.W., et al. (2017) The Global Incidence of Appendicitis: A Systematic Review of Population-Based Studies. Annals of Surgery, 266, 237-241. [Google Scholar] [CrossRef
[2] Di Saverio, S., Podda, M., De Simone, B., Ceresoli, M., Augustin, G., Gori, A., et al. (2020) Diagnosis and Treatment of Acute Appendicitis: 2020 Update of the WSES Jerusa-lem Guidelines. World Journal of Emergency Surgery: WJES, 15, 27. [Google Scholar] [CrossRef] [PubMed]
[3] Akbulut, S., Koç, C., Şahin, T.T., Şahin, E., Tuncer, A., Demyati, K., et al. (2021) An Investigation into the Factors Predicting Acute Appendicitis and Perforated Appendicitis. Turkish Journal of Trauma & Emergency Surgery: TJTES, 27, 434-442. [Google Scholar] [CrossRef] [PubMed]
[4] Bhangu, A., Søreide, K., Di Saverio, S. et al. (2015) Acute Appen-dicitis: Modern Understanding of Pathogenesis, Diagnosis, and Management. The Lancet (London, England), 386, 1278-1287. [Google Scholar] [CrossRef
[5] Thuijls, G., Derikx, J.P., Prakken, F.J., Huisman, B., van Bijnen Ing, A.A., van Heurn, E.L., et al. (2011) A Pilot Study on Potential New Plasma Markers for Diagnosis of Acute Appendicitis. The American Journal of Emergency Medicine, 29, 256-260. [Google Scholar] [CrossRef] [PubMed]
[6] Hajibandeh, S., Hajibandeh, S. and Hobbs, N. (2020) Neutro-phil-to-Lymphocyte Ratio Predicts Acute Appendicitis and Distinguishes between Complicated and Uncomplicated Ap-pendicitis: A Systematic Review and Meta-Analysis. American Journal of Surgery, 219, 154-163. [Google Scholar] [CrossRef] [PubMed]
[7] Bhangu, A. (2014) Safety of Short, In-Hospital Delays before Surgery for Acute Appendicitis: Multicentre Cohort Study, Systematic Review, and Meta-Analysis. Annals of Surgery, 259, 894-903. [Google Scholar] [CrossRef
[8] Imaoka, Y., Itamoto, T., Takakura, Y., Suzuki, T., Ikeda, S. and Urushihara, T. (2016) Validity of Predictive Factors of Acute Complicated Appendicitis. World Journal of Emer-gency Surgery: WJES, 11, 48. [Google Scholar] [CrossRef] [PubMed]
[9] Yamazaki, S., Shimodaira, Y., Kobayashi, A., Takata, M., Hayashibara, K., Sakon, M., et al. (2021) Predictive Factors of Perforated Appendicitis: Impact of the C-Reactive Protein Level. Surgery Open Science, 6, 1-4. [Google Scholar] [CrossRef] [PubMed]
[10] Buckius, M.T., McGrath, B., Monk, J., Grim, R., Bell, T. and Ahuja, V. (2012) Changing Epidemiology of Acute Appendicitis in the United States: Study Period 1993-2008. The Journal of Surgical Research, 175, 185-190. [Google Scholar] [CrossRef] [PubMed]
[11] Anderson, J.E., Bickler, S.W., Chang, D.C. and Talamini, M.A. (2012) Examining a Common Disease with Unknown Etiology: Trends in Epidemiology and Surgical Management of Appendicitis in California, 1995-2009. World Journal of Surgery, 36, 2787-2794. [Google Scholar] [CrossRef] [PubMed]
[12] Hanson, K.A., Jacob, D., Alhaj Saleh, A. and Dissanaike, S. (2020) In-Hospital Perforation Risk in Acute Appendicitis: Age Matters. American Journal of Surgery, 219, 65-70. [Google Scholar] [CrossRef] [PubMed]
[13] Schwartz, K. and Nguyen, M. (2021) Spatial-Temporal Clusters of Pediatric Perforated Appendicitis in California. Journal of Pediatric Surgery, 56, 1208-1213. [Google Scholar] [CrossRef] [PubMed]
[14] Levi, M., van der Poll, T. and Büller, H.R. (2004) Bidirectional Relation between Inflammation and Coagulation. Circulation, 109, 2698-2704. [Google Scholar] [CrossRef
[15] Kahramanca, S., Ozgehan, G. and Seker, D. (2014) Neutrophil-to-Lymphocyte Ratio as a Predictor of Acute Appendicitis. Turkish Journal of Trauma & Emergency Surgery: TJTES, 20, 19-22. [Google Scholar] [CrossRef] [PubMed]
[16] Bröker, M.E., van Lieshout, E.M. and van der Elst, M. (2012) Discriminating between Simple and Perforated Appendicitis. The Journal of Surgical Research, 176, 79-83. [Google Scholar] [CrossRef] [PubMed]
[17] Prada-Arias, M., Vázquez, J.L. and Salgado-Barreira, Á. (2017) Di-agnostic Accuracy of Fibrinogen to Differentiate Appendicitis from Nonspecific Abdominal Pain in Children. The Amer-ican Journal of Emergency Medicine, 35, 66-70. [Google Scholar] [CrossRef] [PubMed]
[18] Menteş, O., Eryılmaz, M. and Harlak, A. (2012) The Value of Se-rum Fibrinogen Level in the Diagnosis of Acute Appendicitis. Turkish Journal of Trauma & Emergency Surgery: TJTES, 18, 384-388. [Google Scholar] [CrossRef] [PubMed]
[19] Morandi, A., Cipriani, E., Parolini, F., Consonni, D., Calderini, E., Franzini, S., et al. (2020) The Coagulation Profile as a Marker for Acute Appendicitis in the Paediatric Population: Ret-rospective Study. African Journal of Paediatric Surgery: AJPS, 17, 59-63. [Google Scholar] [CrossRef
[20] Alvarez-Alvarez, F.A., Maciel-Gutierrez, V.M. and Rocha-Muñoz, A.D. (2016) Diagnostic Value of Serum Fibrinogen as a Predictive Factor for Complicated Appendicitis (Perforated). A Cross-Sectional Study. International Journal of Surgery (London, England), 25, 109-113. [Google Scholar] [CrossRef] [PubMed]
[21] Li, J., Liu, Y., Yin, W., Zhang, C., Huang, J., Liao, C., et al. (2011) Alterations of the Preoperative Coagulation Profile in Patients with Acute Appendicitis. Clinical Chemistry and Labora-tory Medicine, 49, 1333-1339. [Google Scholar] [CrossRef
[22] Giordano, S., Pääkkönen, M., Salminen, P. and Grönroos, J.M. (2013) Elevated Serum Bilirubin in Assessing the Likelihood of Perforation in Acute Appendicitis: A Diagnostic Me-ta-Analysis. International Journal of Surgery (London, England), 11, 795-800. [Google Scholar] [CrossRef] [PubMed]
[23] Akai, M., Iwakawa, K., Yasui, Y., Yoshida, Y., Kato, T., Kitada, K., et al. (2019) Hyperbilirubinemia as a Predictor of Severity of Acute Appendicitis. The Journal of International Medical Research, 47, 3663-3669. [Google Scholar] [CrossRef] [PubMed]
[24] Emmanuel, A., Murchan, P., Wilson, I. and Balfe, P. (2011) The Value of Hyperbilirubinaemia in the Diagnosis of Acute Appendicitis. Annals of the Royal College of Surgeons of Eng-land, 93, 213-217. [Google Scholar] [CrossRef
[25] Shuaib, A., Alhamdan, N. and Arian, H. (2022) Hyperbiliru-binemia and Hyponatremia as Predictors of Complicated Appendicitis. Medical Sciences (Basel, Switzerland), 10, Article No. 36. [Google Scholar] [CrossRef] [PubMed]
[26] Cozzi, G., Galdo, F. and Germani, C. (2018) Still Toddler: A Clinical Clue for Acute Appendicitis. Journal of Paediatrics and Child Health, 54, 913-914. [Google Scholar] [CrossRef] [PubMed]
[27] Sand, M., Bechara, F.G. and Holland-Letz, T. (2009) Diagnostic Value of Hyperbilirubinemia as a Predictive Factor for Appendiceal Perforation in Acute Appendicitis. American Journal of Sur-gery, 198, 193-198. [Google Scholar] [CrossRef] [PubMed]
[28] Larsen, S.B., Grove, E.L. and Hvas, A.M. (2014) Platelet Turnover in Stable Coronary Artery Disease—Influence of Thrombopoietin and Low-Grade Inflammation. PLOS ONE, 9, e85566. [Google Scholar] [CrossRef] [PubMed]
[29] Dinc, B., Oskay, A. and Dinc, S.E. (2015) New Pa-rameter in Diagnosis of Acute Appendicitis: Platelet Distribution Width. World Journal of Gastroenterology, 21, 1821-1826. [Google Scholar] [CrossRef] [PubMed]
[30] Yüksel, O., Helvaci, K. and Başar, O. (2009) An Over-looked Indicator of Disease Activity in Ulcerative Colitis: Mean Platelet Volume. Platelets, 20, 277-281. [Google Scholar] [CrossRef] [PubMed]
[31] Thachil, J. (2015) Platelets in Inflammatory Disorders: A Path-ophysiological and Clinical Perspective. Seminars in Thrombosis and Hemostasis, 41, 572-581. [Google Scholar] [CrossRef] [PubMed]
[32] Gasparyan, A.Y., Ayvazyan, L. and Mikhailidis, D.P. (2011) Mean Platelet Volume: A Link between Thrombosis and Inflammation? Current Pharmaceutical Design, 17, 47-58. [Google Scholar] [CrossRef] [PubMed]
[33] Fan, Z., Pan, J. and Zhang, Y. (2015) Mean Platelet Volume and Platelet Distribution Width as Markers in the Diagnosis of Acute Gangrenous Appendicitis. Disease Markers, 2015, Article ID: 542013. [Google Scholar] [CrossRef] [PubMed]
[34] Haghi, A.R., Pourmohammad, P. and Rabiee, M.A.S. (2020) Accuracy of Mean Platelet Volume (MPV) and Red Cell Distribution Width (RDW) for the Diagnosis of Acute Appendicitis: Evaluation of Possible New Biomarkers. Advanced Journal of Emergency Medicine, 4, e20.