卵巢类固醇细胞瘤1例并文献复习

Ovarian Steroid Cell Tumor: A Case Report and Literature Review

摘要: 目的：通过分析卵巢类固醇细胞瘤(steroid cell tumor, SCT)的临床特点、临床表现、诊断与鉴别诊断及治疗与预后，同时阅读最新文献，总结最新诊疗方法，以提高该疾病的诊疗水平。方法：分析青岛大学附属医院收治的1例卵巢类固醇细胞瘤的诊治经过，并复习国内外文献。结果：患者张某，因“停经8年，下颌小须，四肢多毛伴脱发3年余，发现盆腔肿物1月”入院，入院后完善相关辅助检查，排除禁忌后行腹腔镜探查术，术后病理：右卵巢类固醇细胞瘤。结论：SCT是一种罕见的卵巢性索–间质肿瘤，WHO分为非特异性SCT和Leydig细胞瘤。最常见临床表现是血清睾酮升高，出现男性特征。免疫组化α-inhibin、calretinin阳性。治疗首选手术治疗。

Abstract: Objective: To analyze the clinical features, clinical manifestations, diagnosis, differential diagnosis, treatment and prognosis of steroid cell tumor (SCT) of the ovary, read the latest literature, and summarize the latest diagnosis and treatment methods in order to improve the diagnosis and treatment of the disease. Methods: The diagnosis and treatment of 1 case of ovarian steroid cell tu-mor treated in the Affiliated Hospital of Qingdao University were analyzed, and the literatures at home and abroad were reviewed. Results: The patient, Zhang, was admitted due to “menopause for 8 years, small mandibular beard, hirsutism of four extremities with alopecia for more than 3 years, and pelvic mass for 1 month”. After admission, relevant auxiliary examinations were perfected, and laparoscopic exploration was performed after excluding contraindications. Postoperative pathology: steroid cell tumor of the right ovary. Conclusion: SCT is a rare sex cord-stromal tumor of the ovary, which is divided into nonspecific SCT and Leydig cell tumor by WHO. The most common clinical presentation is elevated serum testosterone, which presents with male characteristics. Immuno-histochemistry was positive for α-inhibin and calretinin. Surgical treatment is the first choice for treatment.