结肠癌肝转移治疗的研究进展
Research Progress in the Treatment of Liver Metastasis from Colon Cancer
DOI: 10.12677/ACM.2022.12121612, PDF,    科研立项经费支持
作者: 郑龙坤：济宁医学院临床医学院，山东 济宁；张保贵*：济宁医学院附属医院胃肠外科，山东 济宁
关键词: 结肠癌；肝转移；治疗；Colon Cancer； Liver Metastasis； Treatment
摘要: 结肠癌是我国目前最常见的肿瘤之一，极易发生转移，而肝脏又是最容易发生受累的器官。据统计，在结肠癌治疗的过程中，约50%的结肠癌患者可能发生肝转移，严重影响患者的预后。本综述旨在总结近年来结肠癌肝转移治疗的方式，为临床进一步治疗结肠癌肝转移提供一种思路和选择。
Abstract: Colon cancer is one of the most common tumors in China, which is prone to metastasis, and the liver is the most vulnerable organ. According to statistics, in the process of colon cancer treatment, about 50% of colon cancer patients may have liver metastasis, which seriously affects the prognosis of pa-tients. The purpose of this review is to summarize some treatment methods for liver metastasis of colon cancer in recent years, and to provide an idea and choice for further clinical treatment of liver metastasis of colon cancer.
文章引用：郑龙坤, 张保贵. 结肠癌肝转移治疗的研究进展[J]. 临床医学进展, 2022, 12(12): 11179-11185. https://doi.org/10.12677/ACM.2022.12121612

参考文献

[1] Sung, H., Ferlay, J., Siegel, R.L., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
[2] 张娜, 于宏杰, 王英鉴, 等. 上海市嘉定区1996-2016年结直肠癌流行规律分析[J]. 复旦学报(医学版), 2020, 47(5): 707-714.
[3] Yang, J., Kim, H., Shin, K., et al. (2020) Molecular Insights into the Development of Hepatic Metastases in Colorectal Cancer: A Metastasis Prediction Study. European Re-view for Medical and Pharmacological Sciences, 24, 12701-12708.
[4] Ahmed, N., Oliva, K., Wang, Y., et al. (2003) Proteomic Profiling of Proteins Associated with Urokinase Plasminogen Activator Receptor in a Colon Cancer Cell Line Using an Antisense Approach. Proteomics, 3, 288-298. [Google Scholar] [CrossRef] [PubMed]
[5] Cai, S.R., et al. (2011) Performance of a Colorectal Cancer Screening Protocol in an Economically and Medically Underserved Population. Cancer Prevention Research (Philadelphia, Pa.), 4, 1572-1579. [Google Scholar] [CrossRef] 
[6] Adam, R., de Gramont, A., Figueras, J., et al. (2015) Managing Synchronous Liver Metastases from Colorectal Cancer: A Multidisciplinary International Consensus. Cancer Treatment Reviews, 41, 729-741. [Google Scholar] [CrossRef] [PubMed]
[7] 高显华, 刘鹏, 龚海峰, 等. 升结肠癌伴严重肝多发转移一例[J]. 中华胃肠外科杂志, 2017, 20(10): 1199-1202.
[8] Fujimura, M., Bang, O.Y. and Kim, J.S. (2016) Moyamoya Disease. Frontiers of Neurology and Neuroscience, 40, 204-220. [Google Scholar] [CrossRef] [PubMed]
[9] 赵之明, 谭向龙, 刘荣. 结直肠癌同步肝转移的治疗现状及研究进展[J]. 中华胃肠外科杂志, 2020, 23(6): 619-622.
[10] 李晓红, 杨丽, 李婉澜, 等. CA50及CA199在结肠癌患者中的临床应用价值[J]. 检验医学与临床, 2015, 12(21): 3248-3250.
[11] Samim, M., Molenaar, I.Q., Seesing, M., et al. (2017) The Diagnostic Performance of (18)F-FDG PET/CT, CT and MRI in the Treatment Evaluation of Ablation Therapy for Colorectal Liver Metastases: A Systematic Review and Meta-Analysis. Surgical Oncology, 26, 37-45. [Google Scholar] [CrossRef] [PubMed]
[12] 李成东, 赖少伟, 何俞, 等. CT联合血清CEA和CA199检测对乙状结肠癌患者肝转移的诊断价值[J]. 中国肿瘤临床与康复, 2018, 25(8): 961-964. [Google Scholar] [CrossRef] 
[13] Syn, N.L., Kabir, T., Koh, Y.X., et al. (2020) Survival Advantage of Laparoscopic versus Open Resection for Colorectal Liver Metastases: A Me-ta-Analysis of Individual Patient Data from Randomized Trials and Propensity-Score Matched Studies. Annals of Surgery, 272, 253-265. [Google Scholar] [CrossRef] 
[14] Nordlinger, B., Quilichini, M.A., Parc, R., et al. (1987) Hepatic Resection for Colorectal Liver Metastases. Influence on Survival of Preoperative Factors and Surgery for Recurrences in 80 Patients. Annals of Surgery, 205, 256-263. [Google Scholar] [CrossRef] [PubMed]
[15] Bogach, J., Wang, J., Griffiths, C., et al. (2020) Simul-taneous versus Staged Resection for Synchronous Colorectal Liver Metastases: A Population-Based Cohort Study. In-ternational Journal of Surgery, 74, 68-75. [Google Scholar] [CrossRef] [PubMed]
[16] Fretland, Å.A., Dagenborg, V.J., Waaler Bjørnelv, G.M., et al. (2019) Quality of Life from a Randomized Trial of Laparoscopic or Open Liver Resection for Colorectal Liver Metastases. British Journal of Surgery, 106, 1372-1380. [Google Scholar] [CrossRef] [PubMed]
[17] Shin, J.K., Kim, H.C., Lee, W.Y., et al. (2020) Comparative Study of Lapa-roscopic versus Open Technique for Simultaneous Resection of Colorectal Cancer and Liver Metastases with Propensity Score Analysis. Surgical Endoscopy, 34, 4772-4780. [Google Scholar] [CrossRef] [PubMed]
[18] Fung, A. and Lee, K.F. (2019) Robotic Resection for Posterosuperior Liver Lesions: Is It Really Superior to Laparoscopic Resec-tion. Hepatobiliary Surgery and Nutrition, 8, 264-266. [Google Scholar] [CrossRef] [PubMed]
[19] 郑好, 卢伟. 经肝动脉灌注奥沙利铂联合卡培他滨治疗结肠癌肝转移[J]. 中国介入影像与治疗学, 2019, 16(3): 149-153. [Google Scholar] [CrossRef] 
[20] Rahman, S., Toogood, G.J., Lodge, P.J., et al. (2003) Role of Neoadjuvant Chemotherapy in the Treatment of Multiple colorectal Metastases to the Liver. British Journal of Surgery, 90, 963-969. [Google Scholar] [CrossRef] [PubMed]
[21] Wang, C., Park, J., Ouyang, C., et al. (2020) A Pilot Feasibility Study of Yttrium-90 Liver Radioembolization Followed by Durvalumab and Tremelimumab in Patients with Microsatel-lite Stable Colorectal Cancer Liver Metastases. Oncologist, 25, e382-e776. [Google Scholar] [CrossRef] [PubMed]
[22] Kim, J.H., Sun, Y.K., Ji, Y.B., et al. (2020) A Phase II Study of Avelumab Monotherapy in Patients with Mismatch Repair-Deficient/Microsatellite Instability-High or POLE-Mutated Metastatic or Unresectable Colorectal Cancer. Cancer Research and Treatment, 52, 1135-1144. [Google Scholar] [CrossRef] [PubMed]
[23] Chisato, H. (2020) The Burden of Gastric Cancer. Annals of Translation-al Medicine, 8, 734-734. [Google Scholar] [CrossRef] [PubMed]
[24] Jabbari, N., Kenerson, H.L., Lausted, C., et al. (2020) Modulation of Immune Checkpoints by Chemotherapy in Human Colorectal Liver Metastases. Cell Reports Medicine, 1, Article ID: 100160. [Google Scholar] [CrossRef] [PubMed]
[25] Lu, Y.C., Jia, L., Zheng, Z., Tran, E., et al. (2019) Single-Cell Transcriptome Analysis Reveals Gene Signatures Associated with T-Cell Persistence Following Adoptive Cell Therapy. Cancer Immunology Research, 7, 1824-1836. [Google Scholar] [CrossRef] 
[26] Sur, D., Havasi, A., Cainap, C., et al. (2020) Chimeric Anti-gen Receptor T-Cell Therapy for Colorectal Cancer. Journal of Clinical Medicine, 9, Article No. 182. [Google Scholar] [CrossRef] [PubMed]
[27] Hompes, D., Prevoo, W. and Ruers, T. (2011) Radiofrequency Ablation as a Treatment Tool for Liver Metastases of Colorectal Origin. Cancer Imaging, 11, 23-30.
[28] Takahashi, H. and Ber-ber, E. (2020) Role of Thermal Ablation in the Management of Colorectal Liver Metastasis. Hepatobiliary Surgery and Nutrition, 9, 49-58. [Google Scholar] [CrossRef] [PubMed]
[29] Han, K., Kim, J.H., Yang, S.G., et al. (2021) A Single-Center Retrospective Analysis of Periprocedural Variables Affecting Local Tumor Progression after Radiofre-quency Ablation of Colorectal Cancer Liver Metastases. Radiology, 298, 212-218. [Google Scholar] [CrossRef] [PubMed]
[30] Di Martino, M., Rompianesi, G., Mora-Guzmán, I., et al. (2020) Systematic Review and Meta-Analysis of Local Ablative Therapies for Resectable Colorectal Liver Metastases. European Journal of Surgical Oncology, 46, 772-781. [Google Scholar] [CrossRef] [PubMed]
[31] Mühlbacher, F., Huk, I., Steininger, R., et al. (1991) Is Orthotopic Liver Transplantation a Feasible Treatment for Secondary Cancer of the Liver. Transplantation Proceedings, 23, 1567-1568.
[32] Dueland, S., Syversveen, T., Solheim, J.M., et al. (2020) Survival Following Liver Transplantation for Patients with Nonresectable Liver-Only Colorectal Metastases. Annals of Surgery, 271, 212-218. [Google Scholar] [CrossRef] 
[33] Bjørnelv, G., Dueland, S., Line, P.D., et al. (2019) Cost-Effectiveness of Liver Transplantation in Patients with Colorectal Metastases Confined to the Liver. British Journal of Surgery, 106, 132-141. [Google Scholar] [CrossRef] [PubMed]
[34] Hibi, T., Rela, M., Eason, J.D., et al. (2020) Liver Transplantation for Colorectal and Neuroendocrine Liver Metastases and Hepatoblastoma. Working Group Report from the ILTS Transplant Oncology Consensus Conference. Transplantation, 104, 1131-1135. [Google Scholar] [CrossRef] 
[35] Chen, M., Zhuang, Y.W., Wu, C.E., et al. (2021) β-Asarone Suppresses HCT116 Colon Cancer Cell Proliferation and Liver Metastasis in Part by Activating the Innate Immune Sys-tem. Oncology Letters, 21, 435. [Google Scholar] [CrossRef] [PubMed]
[36] Zhao, L., Zhu, X., Ni, Y., et al. (2020) Xiaoyaosan, a Traditional Chi-nese Medicine, Inhibits the Chronic Restraint Stress-Induced Liver Metastasis of Colon Cancer in Vivo. Pharmaceutical Biology, 58, 1085-1091. [Google Scholar] [CrossRef] [PubMed]
[37] Zhou, J.Y., Chen, M., Wu, C.E., et al. (2019) The Modified Si-Jun-Zi Decoction Attenuates Colon Cancer Liver Metastasis by Increasing Macrophage Cells. BMC Complementary and Alternative Medicine, 19, Article No. 86. [Google Scholar] [CrossRef] [PubMed]
[38] 马漪, 文静. 白头翁总皂苷调控CXCR4/CXCL12信号通路抑制小鼠结肠癌肝转移的机制研究[J]. 吉林中医药, 2021, 41(8): 1080-1085. [Google Scholar] [CrossRef] 

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