以气道平滑肌为靶点的支气管热成形术研究进展
Research Progress of Bronchial Thermoplasty Targeting Airway Smooth Muscle
DOI: 10.12677/ACM.2022.12121615, PDF,    科研立项经费支持
作者: 方章兰, 祝筱茜, 阳 昊, 罗 玲*：重庆大学附属肿瘤医院，重庆
关键词: 支气管哮喘；气管平滑肌；支气管热成形术；Bronchial Asthma； Airway Smooth Muscle； Bronchial Thermoplasty
摘要: 支气管哮喘已逐渐成为严重危害世界各国居民生命健康的重大疾病，而气道平滑肌(ASM)作为气道壁的组成部分，是支气管哮喘治疗的一个新兴靶点，支气管热成形术(BT)就是一项针对重症哮喘患者，以ASM为治疗靶点的内镜下介入技术，目前已在美国、欧洲、中国和许多其他国家被许可用于治疗哮喘。本文总结了BT治疗支气管哮喘的机制研究进展以及真实世界中BT治疗的效果与安全性评价，以期为临床指导提供参考意义。
Abstract: Bronchial asthma has gradually become a major disease that seriously endangers the life and health of people all over the world. Airway smooth muscle (ASM), as a component of the airway wall, is a new target for the treatment of bronchial asthma. Bronchial thermoplasty (BT) is an endoscopic intervention technology targeting ASM for patients with severe asthma. It is currently licensed to treat asthma in the United States, Europe, China and many other countries. This paper summarized the research progress of BT treatment mechanism of bronchial asthma and the real world BT treatment effect and safety evaluation, in order to provide reference for clinical guidance.
文章引用：方章兰, 祝筱茜, 阳昊, 罗玲. 以气道平滑肌为靶点的支气管热成形术研究进展[J]. 临床医学进展, 2022, 12(12): 11202-11209. https://doi.org/10.12677/ACM.2022.12121615

参考文献

[1] Rajaram, M., Selvarajan, S., Neelamegan, R., et al. (2019) Effects of Genetic Polymorphisms in Vitamin D Metabolic Pathway on Vitamin D Level and Asthma Control in South Indian Patients with Bronchial Asthma. Lung India, 36, 483-491. [Google Scholar] [CrossRef] [PubMed]
[2] 农英, 林江涛, 陈昕, 等. 真实世界重度支气管哮喘患者支气管热成形术后两年的效果评价[J]. 中华医学杂志, 2020, 100(22): 1730-1735.
[3] Aghasafari, P., George, U. and Pidaparti, R. (2019) A Review of Inflammatory Mechanism in Airway Diseases. Inflammation Research, 68, 59-74. [Google Scholar] [CrossRef] [PubMed]
[4] Mandovra, N.P., Leuppi, J.D., Herth, F.J.F. and Chhajed, P.N. (2019) Interventions in Asthma and COPD. Therapeutische Umschau, 76, 328-336. [Google Scholar] [CrossRef] [PubMed]
[5] Brown, R.H., Wizeman, W., Danek, C. and Mitzner, W. (2005) Effect of Bronchial Thermoplasty on Airway Distensibility. European Respiratory Journal, 26, 277-282. [Google Scholar] [CrossRef] [PubMed]
[6] 顾宪民, 林江涛, 农英, 等. 支气管热成形术对重症支气管哮喘患者气道重塑、哮喘控制水平和生活质量的影响[J]. 中华医学杂志, 2020, 100(20): 1573-1577.
[7] James, A.L., Elliot, J.G., Jones, R.L., et al. (2012) Airway Smooth Muscle Hypertrophy and Hyperplasia in Asthma. American Journal of Respiratory and Critical Care Medicine, 185, 1058-1064. [Google Scholar] [CrossRef] 
[8] Pepe, C., Foley, S., Shannon, J., et al. (2005) Differences in Airway Remodeling between Subjects with Severe and Moderate Asthma. Journal of Allergy and Clinical Immunology, 116, 544-549. [Google Scholar] [CrossRef] [PubMed]
[9] 钟志成, 陈娉娉, 李静, 等. 支气管热成形术治疗支气管哮喘的机制探究[J]. 国际呼吸杂志, 2017, 37(23): 1824-1827.
[10] Dowell, M.L., Lavoie, T.L., Solway, J. and Krishnan, R. (2014) Airway Smooth Muscle: A Potential Target for Asthma Therapy. Current Opinion in Pulmonary Medicine, 20, 66-72. [Google Scholar] [CrossRef] 
[11] Danek, C.J., Lombard, C.M., Dungworth, D.L., et al. (2004) Reduction in Airway Hyperresponsiveness to Methacholine by the Application of RF Energy in Dogs. Journal of Applied Physiology, 97, 1946-1953. [Google Scholar] [CrossRef] [PubMed]
[12] Miller, J.D., Cox, G., Vincic, L., et al. (2005) A Prospective Feasibility Study of Bronchial Thermoplasty in the Human Airway. Chest, 127, 1999-2006. [Google Scholar] [CrossRef] [PubMed]
[13] Chakir, J., Haj-Salem, I., Gras, D., et al. (2015) Effects of Bronchial Thermoplasty on Airway Smooth Muscle and Collagen Deposition in Asthma. Annals of the American Thoracic Society, 12, 1612-1618. [Google Scholar] [CrossRef] 
[14] Salem, I.H., Boulet, L.P., Biardel, S., et al. (2016) Long-Term Effects of Bronchial Thermoplasty on Airway Smooth Muscle and Reticular Basement Membrane Thickness in Severe Asthma. Annals of the American Thoracic Society, 13, 1426-1428. [Google Scholar] [CrossRef] 
[15] Pretolani, M., Bergqvist, A., Thabut, G., et al. (2017) Ef-fectiveness of Bronchial Thermoplasty in Patients with Severe Refractory Asthma: Clinical and Histopathologic Correla-tions. Journal of Allergy and Clinical Immunology, 139, 1176-1185. [Google Scholar] [CrossRef] [PubMed]
[16] Denner, D.R., Doeing, D.C., Hogarth, D.K., et al. (2015) Airway Inflammation after Bronchial Thermoplasty for Severe Asthma. Annals of the American Thoracic Society, 12, 1302-1309. [Google Scholar] [CrossRef] 
[17] U. S. National Institutes of Health (2018).
https://clinicaltrials.gov/
[18] Goorsenberg, A, d’Hooghe, J.N.S., Srikanthan, K., et al. (2021) Bronchial Thermo-plasty Induced Airway Smooth Muscle Reduction and Clinical Response in Severe Asthma. The TASMA Randomized Trial. American Journal of Respiratory and Critical Care Medicine, 203, 175-184. [Google Scholar] [CrossRef] 
[19] d’Hooghe, J.N.S., Goorsenberg, A.W.M., Ten Hacken, N.H.T., et al. (2019) Airway Smooth Muscle Reduction after Bronchial Thermoplasty in Severe Asthma Correlates with FEV1. Clinical & Experimental Allergy, 49, 541-544. [Google Scholar] [CrossRef] [PubMed]
[20] Zanon, M., Strieder, D.L., Rubin, A.S., et al. (2017) Use of MDCT to As-sess the Results of Bronchial Thermoplasty. American Journal of Roentgenology, 209, 752-756. [Google Scholar] [CrossRef] 
[21] Ishii, S., Iikura, M., Hojo, M. and Sugiyama, H. (2017) Use of 3D-CT Airway Analysis Software to Assess a Patient with Severe Persistent Bronchial Asthma Treated with Bronchial Thermo-plasty. Allergology International, 66, 501-503. [Google Scholar] [CrossRef] [PubMed]
[22] Kirby, M., Ohtani, K., Lopez Lisbona, R.M., et al. (2015) Bronchial Thermoplasty in Asthma: 2-Year Follow-Up Using Optical Coherence Tomography. European Respiratory Journal, 46, 859-862. [Google Scholar] [CrossRef] [PubMed]
[23] Dyrda, P., Tazzeo, T., DoHarris, L., et al. (2011) Acute Re-sponse of Airway Muscle to Extreme Temperature Includes Disruption of Actin-Myosin Interaction. American Journal of Respiratory Cell and Molecular Biology, 44, 213-221. [Google Scholar] [CrossRef] 
[24] Sopel, N., Klle, J., Dumendiak, S., et al. (2019) Immunoregulato-ry Role of Acid Sphingomyelinase in Allergic Asthma. Immunology, 156, 373-383. [Google Scholar] [CrossRef] [PubMed]
[25] Chakir, J., Salem, I.H., Gras, D., et al. (2017) MUC5AC Expression De-crease Correlates with the Decline in Rates of Severe Asthma Exacerbations Post Bronchial Thermoplasty. European Respiratory Journal, 50, Article No. OA279. [Google Scholar] [CrossRef] 
[26] Russell, R., Singapuri, A., Berair, R., et al. (2017) Clinical and Histological Effects of Bronchial Thermoplasty in Severe Asthma. European Respiratory Journal, 50, Arti-cle No. PA3031. [Google Scholar] [CrossRef] 
[27] Li, X., Xie, S.-S., Li, G.-S., et al. (2021) Effects of Bronchial Thermoplasty and Cryoablation on Airway Smooth Muscle. Chinese Medical Journal, 134, 2166-2174. [Google Scholar] [CrossRef] 
[28] Ryan, D.M., Fowler, S.J. and Niven, R.M. (2016) Reduc-tion in Peripheral Blood Eosinophil Counts after Bronchial Thermoplasty. Journal of Allergy and Clinical Immunology, 138, 308-310. [Google Scholar] [CrossRef] [PubMed]
[29] 李譞, 谢栓栓, 段洪霞, 等. 支气管热成形术对难治性哮喘患者肺功能、血嗜酸性粒细胞数及HRCT下管腔面积的影响[J]. 同济大学学报(医学版), 2020, 41(3): 325-330.
[30] Debray, M.-P., Dombret, M.-C., Pretolani, M., et al. (2017) Early Computed Tomography Modifications Following Bronchial Thermoplasty in Patients with Severe Asthma. European Respiratory Journal, 49, Article ID: 1601565. [Google Scholar] [CrossRef] [PubMed]
[31] d’Hooghe, J.N.S., van den Berk, I.A.H., Annema, J.T. and Bonta, P.I. (2017) Acute Radiological Abnormalities after Bronchial Thermoplasty: A Prospective Cohort Trial. Respira-tion, 94, 258-262. [Google Scholar] [CrossRef] [PubMed]
[32] Farah, C., Langton, D., Pierucci, P. and Ing, A. (2017) Changes in Lung Function and Forced Oscillatory Technique (FOT) Parameters Following Bronchial Thermoplasty (BT) in Patients with Refractory Asthma. American Journal of Respiratory and Critical Care Medicine, 195, Article No. A6497.
[33] Baydur, A., Virdi, R. and Barbers, R. (2017) Lung Compliance and Resistance in Patients with Severe Persistent Asthma before and after Undergoing Bronchial Thermoplasty: A Pilot Study. American Journal of Respiratory and Critical Care Medicine, 195, Article No. A6496.
[34] Boulet, L.P. and Laviolette, M. (2017) Acute Effects of Bronchial Thermoplasty: A Matter of Concern or an Indicator of Possible Benefit to Small Airways? European Respira-tory Journal, 49, Article ID: 1700029. [Google Scholar] [CrossRef] [PubMed]
[35] Langton, D., Banks, C., Noble, P.B., et al. (2020) The Effect of Bronchial Thermoplasty on Airway Volume Measured 12 Months Post-Procedure. ERJ Open Research, 6, Article ID: 00300-2020. [Google Scholar] [CrossRef] [PubMed]
[36] Bicknell, S., Chaudhuri, R., Lee, N., et al. (2015) Effectiveness of Bronchial Thermoplasty in Severe Asthma in ‘Real Life’ Patients Compared with Those Recruited to Clinical Trials in the Same Centre. Therapeutic Advances in Respiratory Disease, 9, 267-271. [Google Scholar] [CrossRef] [PubMed]
[37] Goorsenberg, A.W.M., d’Hooghe, J.N.S., Slats, A.M., et al. (2020) Resistance of the Respiratory System Measured with Forced Oscillation Technique (FOT) Correlates with Bron-chial Thermoplasty Response. Respiratory Research, 21, Article No. 52. [Google Scholar] [CrossRef] [PubMed]
[38] 刘国梁. 支气管热成形术治疗重症支气管哮喘的有效性和安全性研究[J]. 中华结核和呼吸杂志, 2011, 34(3): 191-191.
[39] Aftab, G.M., Rehman, S., Ahmad, M., Akram, A. and Bukhari, A. (2021) Bronchial Thermoplasty in Patients with Severe Persistent Asthma: A Literature Review. Journal of Community Hospital Internal Medicine Perspectives, 11, 518-522. [Google Scholar] [CrossRef] [PubMed]
[40] Qiu, M., Lai, Z., Wei, S., et al. (2018) Bronchiectasis after Bronchial Thermoplasty．Journal of Thoracic Disease, 10, E721-E726. [Google Scholar] [CrossRef] [PubMed]
[41] 龙发, 付鹏, 黄文婷, 等. 探讨450例次支气管热成形术治疗重度哮喘术后近期严重并发症的处理策略[J]. 心肺血管病杂志, 2019, 38(5): 473-475.
[42] 农英, 林江涛, 苏楠, 等. 183例次支气管热成形术后近期呼吸不良事件分析[J]. 中华结核和呼吸杂志, 2017, 40(3): 176-181.

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