基于SEER数据库乳腺小管癌临床病理特征及预后因素分析

Analysis of Clinicopathological Features and Prognosis Factors of Tubular Carcinoma of the Breast Based on SEER Database

摘要: 目的：探讨乳腺小管癌的临床病理特征、预后及相关影响因素。方法：根据入组和排除标准从美国国立癌症研究监测、流行病学和最终结局(SEER)数据库中选择1973~2015年诊断为乳腺小管癌的1624例病例资料，回顾性分析其临床病理特征与生存情况，及其预后影响因素。结果：在1624例病人中，1557例(95.9%)为T1期，1554例(95.7%)为N0期，1599例(98.5%)接受手术治疗，915例(56.3%)接受放疗，90例(5.5%)接受化疗。病人3、5年总体生存率分别为97.4%、93.8%。单因素分析显示，年龄、婚姻状态、T分期、手术、放疗是影响乳腺小管癌病人生存预后的相关因素(P < 0.05)。多因素分析显示，年龄、婚姻状态、放疗是影响乳腺小管癌病人预后的独立危险因素(P < 0.05)。结论：影响乳腺小管癌患者预后的独立危险因素包括年龄、婚姻状态、放疗。放疗对乳腺小管癌患者的总生存率是否有益有待进一步研究探讨。

Abstract: Objective: To investigate the clinicopathological features, prognosis and related influencing factors of patients with tubular carcinoma of the breast. Methods: Data on 1624 cases diagnosed with tubular carcinoma of breast from 1973~2015 from Surveillance, Epidemiology, and End Results (SEER) database based on inclusion and exclusion criteria, the clinicopathological characteristics, survival and prognostic factors were retrospectively analyzed. Results: Among the selected 1624 patients with tubular carcinoma of breast, 1557 cases (95.9%) were T1 stage, 1554 cases (95.7%) were N0 stage, 1599 cases (98.5%) received surgery, 915 cases (56.3%) received radiotherapy, and 90 cases (5.5%) receive chemotherapy. The overall 3- and 5-year survival rates were 97.4% and 93.8%, respectively. Univariate analysis showed that age, marital status, T stage, surgery and radiotherapy were significantly associated with the prognosis of the patients with tubular carci-noma of breast (P < 0.05). Multivariate analysis revealed that age, marital status and radiotherapy were independent risk factors for prognosis of the patients with tubular carcinoma of breast (P < 0.05). Conclusion: The independent risk factors affecting the prognosis of patients with tubular car-cinoma of the breast are age, marital status and radiotherapy. Whether radiotherapy is beneficial to the survival of patients with tubular carcinoma of breast is still necessary to be further studied.