自噬在低剪切力诱导动脉粥样硬化发生发展中的作用
Role of Autophagy in the Occurrence and Development of Atherosclerosis Induced by Low Shear Stress
DOI: 10.12677/ACM.2022.12121632, PDF,   
作者: 王志洪, 李 丽*:暨南大学附属广州市红十字会医院,广东 广州
关键词: 动脉粥样硬化剪切力自噬内皮细胞Atherosclerosis Shear Stress Autophagy Endothelial Cell
摘要: 动脉粥样硬化(AS)是动脉壁的一种慢性炎症性疾病,发病机制复杂。在动脉血管腔中,动脉粥样硬化斑块的分布与血管壁局部剪切力有很大关系,剪切力低的区域易于产生动脉粥样硬化斑块。自噬是真核细胞的一种高度保守、普遍存在的溶酶体运输途径,通过清除细胞内受损物质来维持细胞稳态,自噬功能障碍也会导致动脉粥样硬化。低剪切力可诱导内皮细胞自噬功能受损,从而导致动脉粥样硬化病变。现就低剪切力通过自噬促进动脉粥样硬化发生发展的研究现状作一综述。
Abstract: Atherosclerosis (AS) is a chronic inflammatory disease of the arterial wall, its pathogenesis is complex. In the vascular lumen, atherosclerotic plaques are not randomly distributed, which has a lot to do with the shear stress generated by the blood flow in the artery, and atherosclerotic plaques develop preferentially in areas where shear is low. Autophagy is a highly conserved and ubiquitous lysosomal transport pathway in eukaryotic cells, which maintains cellular homeostasis by removing damaged substances in cells. Dysfunction of autophagy can also lead to atherosclerosis. Low shear stress might induce endothelial cell autophagy impairment, therefore contributing to atherosclerotic lesions. This article reviews the research status of low shear stress promoting the occurrence and development of atherosclerosis through autophagy.
文章引用:王志洪, 李丽. 自噬在低剪切力诱导动脉粥样硬化发生发展中的作用[J]. 临床医学进展, 2022, 12(12): 11322-11328. https://doi.org/10.12677/ACM.2022.12121632

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