TGF-β促进胰腺癌发展的相关研究进展
Study Progress on TGF-β Promoting the Development of Pancreatic Cancer
DOI: 10.12677/ACM.2022.12121644, PDF,   
作者: 刘 蔚*：哈尔滨医科大学附属第一医院，黑龙江 哈尔滨；祝训浩#：山东第一医科大学附属山东省立医院，山东 济南；王修竹：潍坊医学院临床医学院，山东 潍坊
关键词: 胰腺癌；转化生长因子β；肿瘤微环境；上皮间充质转化；免疫抑制性；Pancreatic Cancer (PC)； Transforming Growth Factor Beta (TGF-β)； Tumor Microenvironment (TME)； Epithelial to Mesenchymal Transition (EMT)； Immunosuppression
摘要: 胰腺癌是一种恶性程度极高的消化道肿瘤。由于早期症状不典型，大多数患者确诊时已丧失手术机会。化疗和靶向治疗是晚期患者的首选，然而目前化疗药物毒性大，总反应率低，因此探索潜在治疗靶点迫在眉睫。TGF-β (transforming growth factor beta, TGF-β)作为一种细胞因子，在肿瘤中的作用越来越受到重视。本综述针对TGF-β在胰腺癌中的作用机制进行全面综述，并探讨其在胰腺癌治疗中的潜在可能。
Abstract: Pancreatic cancer is a highly malignant tumor of the gastrointestinal tract. Due to atypical early symptoms, most patients are already lost to surgery by the time they are diagnosed. Chemotherapy and targeted therapies are the first choice for patients with advanced disease; however, the current high toxicity of chemotherapy drugs and low overall response rates make it urgent to explore potential therapeutic targets. The role of TGF-β as a cytokine in pancreatic cancer has received increasing attention. This review provides a comprehensive review of the mechanism of action of TGF-β in pancreatic cancer and explores its potential possibilities in the treatment of pancreatic cancer.
文章引用：刘蔚, 祝训浩, 王修竹. TGF-β促进胰腺癌发展的相关研究进展[J]. 临床医学进展, 2022, 12(12): 11405-11411. https://doi.org/10.12677/ACM.2022.12121644

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