冷冻胚胎移植不同内膜准备方案与母儿结局
Different Endometrial Preparation of Frozen Embryo Transfer Protocols and Maternal and Fetal Outcomes
DOI: 10.12677/ACM.2022.12121645, PDF,   
作者: 李佳芯：重庆医科大学，重庆；重庆医科大学附属第二医院，重庆；张觇宇：重庆医科大学附属第二医院，重庆
关键词: 冷冻胚胎移植；辅助生殖技术；内膜准备方案；母儿预后；妊娠结局；Frozen Embryo Transfer； Assisted Reproductive Technology； Endometrial Preparation Protocol； Maternal and Infant Prognosis； Pregnancy Outcomes
摘要: 冷冻胚胎移植(Frozen-thawedembryo transfer, FET)在辅助生殖技术(Assisted reproductive tech-nology, ART)中广泛应用，影响冻胚复苏后成功植入的因素有胚胎质量、子宫内膜容受性以及子宫内膜与胚胎发育的同步性，而子宫内膜的准备是其中之关键。目前，辅助生殖助孕的成功不再仅限于妊娠率、活产率等，围产期的母儿结局及预后也值得关注。本文就冷冻胚胎移植不同内膜准备方案对妊娠结局进行总结分析。
Abstract: Frozen embryo transfer (FET) has been widely used in assisted reproductive technology. The factors affecting the successful implantation of frozen embryo after resuscitated include embryo quality, endometrial receptivity and the synchronicity of endometrial and embryo development, among which the preparation of endometrial is the key. At present, the success of assisted reproduction is no longer limited to pregnancy rate and live birth rate, and the outcome and prognosis of mother and child in the perinatal period are also worthy of attention. This paper summarized and analyzed the pregnancy outcome of different endometrial preparation schemes for frozen embryo transfer.
文章引用：李佳芯, 张觇宇. 冷冻胚胎移植不同内膜准备方案与母儿结局[J]. 临床医学进展, 2022, 12(12): 11412-11417. https://doi.org/10.12677/ACM.2022.12121645

参考文献

[1] 唐淮云, 汤丽莎, 尚利青, 等. 三种子宫内膜准备方式在冻融胚胎移植中的结局比较[J]. 吉林医学, 2012, 33(31): 6779-6781.
[2] Matheus, R., Marcello, V., Fernando, G., et al. (2015) Freeze-All Policy: Fresh vs. Frozen-Thawed Embryo Transfer. Fertility and Sterility, 103, 1190-1193. [Google Scholar] [CrossRef] [PubMed]
[3] Liu, S.Y., Teng, B., Fu, J., et al. (2013) Obstetric and Neonatal Outcomes after Transfer of Vitrified Early Cleavage Embryos. Human Reproduction, 28, 2093-2100. [Google Scholar] [CrossRef] [PubMed]
[4] Ginström, E.E., Wennerholm, U.B., Khatibi, A., et al. (2019) Neonatal and Maternal Outcome after Frozen Embryo Transfer: Increased Risks in Programmed Cycles. American Journal of Obstetrics & Gynecology, 221, 126.e1-126.e18. [Google Scholar] [CrossRef] [PubMed]
[5] Wennerholm, U.B., Henningsen, A.K., Romundstad, L.B., et al. (2013) Perinatal Outcomes of Children Born after Frozen-Thawed Embryo Transfer: A Nordic Cohort Study from the CoNARTaS Group. Human Reproduction, 28, 2545-2553. [Google Scholar] [CrossRef] [PubMed]
[6] Zhang, J., Du, M., Li, Z., et al. (2018) Fresh versus Frozen Embryo Transfer for Full-Term Singleton Birth: A Retrospective Co-hort Study. Journal of Ovarian Research, 11, 59. [Google Scholar] [CrossRef] [PubMed]
[7] Wang, B., Zhang, J., Zhu, Q.Q., et al. (2020) Effects of Different Cycle Regimens for Frozen Embryo Transfer on Perinatal Out-comes of Singletons. Human Reproduction, 35, 1612-1622. [Google Scholar] [CrossRef] [PubMed]
[8] Yang, Z., Bai, X., Han, Y., et al. (2022) Adverse Obstetric and Perinatal Outcomes in 2333 Singleton Pregnancies Conceived after Different Endometrial Preparation Protocols: A Retrospective Study in China. BMC Pregnancy Childbirth, 22, Article No. 378. [Google Scholar] [CrossRef] [PubMed]
[9] Hu, K.L., Zhang, D. and Li, R. (2021) Endometrium Preparation and Perinatal Outcomes in Women Undergoing Single-Blastocyst Transfer in Frozen Cycles. Fertility and Sterility, 115, 1487-1494. [Google Scholar] [CrossRef] [PubMed]
[10] Xu, J., Zhou, H., Zhou, T., et al. (2022) The Impact of Dif-ferent Endometrial Preparation Protocols on Obstetric and Neonatal Complications in Frozen-Thawed Embryo Transfer: A Retrospective Cohort Study of 3,458 Singleton Deliveries. Reproductive Biology Endocrinology, 20, 141. [Google Scholar] [CrossRef] [PubMed]
[11] Singh, B., Reschke, L., Segars, J., et al. (2020) Frozen-Thawed Embryo Transfer: The Potential Importance of the Corpus Luteum in Preventing Obstetrical Complications. Fertility and Sterility, 113, 252-257. [Google Scholar] [CrossRef] [PubMed]
[12] Martin, B., Romero, G. and Salama, G. (2019) Cardioprotective Actions of Relaxin. Molecular and Cellular Endocrinology, 487, 45-53. [Google Scholar] [CrossRef] [PubMed]
[13] Ghobara, T., Gelbaya, T.A. and Ayeleke, R.O. (2017) Cycle Regimens for Frozen-Thawed Embryo Transfer. Cochrane Database of Systematic Reviews, 7, CD003414. [Google Scholar] [CrossRef] 
[14] von Versen-Höynck, F., Narasimhan, P., Selamet Tierney, E.S., et al. (2019) Absent or Excessive Corpus Luteum Number Is Associated with Altered Maternal Vascular Health in Early Pregnancy. Hypertension, 73, 680-690. [Google Scholar] [CrossRef] 
[15] Zong, L., Liu, P., Zhou, L., et al. (2020) In-creased Risk of Maternal and Neonatal Complications in Hormone Replacement Therapy Cycles in Frozen Embryo Transfer. Reproductive Biology Endocrinology, 18, 36. [Google Scholar] [CrossRef] [PubMed]
[16] Saito, K., Kuwahara, A., Ishikawa, T., et al. (2019) Endometrial Preparation Methods for Frozen-Thawed Embryo Transfer Are Associated with Altered Risks of Hypertensive Disorders of Pregnancy, Placenta Accreta, and Gestational Diabetes Mellitus. Human Reproduction, 34, 1567-1575. [Google Scholar] [CrossRef] [PubMed]
[17] Kajantie, E., Eriksson, J.G., Osmond, C., et al. (2009) Pre-Eclampsia Is Associated with Increased Risk of Stroke in the Adult Offspring: The Helsinki Birth Cohort Study. Stroke, 40, 1176-1180. [Google Scholar] [CrossRef] 
[18] Saso, S., Louis, L.S., Doctor, F., et al. (2015) Does Fer-tility Treatment Increase the Risk of Uterine Cancer? A Meta-Analysis. The European Journal of Obstetrics & Gyne-cology and Reproductive Biology, 195, 52-60. [Google Scholar] [CrossRef] [PubMed]
[19] Rizzuto, I., Behrens, R.F. and Smith, L.A. (2013) Risk of Ovarian Cancer in Women Treated with Ovarian Stimulating Drugs for Infertility. Cochrane Database of Systematic Reviews, No. 8, CD008215. [Google Scholar] [CrossRef] 
[20] 李美玲. 体外受精-胚胎移植术后远期恶性肿瘤发病及围产期出生缺陷的调查研究[D]: [硕士学位论文]. 天津: 天津医科大学, 2017.
[21] Queenan, J.T. Veeck, L.L., Seltman, H.J., et al. (1994) Transfer of Cryopreserved-Thawed Pre-Embryos in a Natural Cycle or a Programmed Cycle with Exogenous Hormonal Replacement Yields Similar Pregnancy Results. Fertility and Sterility, 62, 545-550. [Google Scholar] [CrossRef] 
[22] Pattinson, H.A., Greene, C.A., Fleetham, J., et al. (1992) Exogenous Control of the Cycle Simplifies Thawed Embryo Transfer and Results in a Pregnancy Rate Similar to That for Natural Cycles. Fertility and Sterility, 58, 627-629. [Google Scholar] [CrossRef] 
[23] 吴静, 黄剑磊, 李博, 等. 两种不同子宫内膜准备方案对FET周期单胎子代围产期结局的影响[J]. 生殖医学杂志, 2021, 30(4): 447-452.
[24] Li, C., He, Y.C., Xu, J.J., et al. (2021) Perinatal Outcomes of Neonates Born from Different Endometrial Preparation Protocols after Frozen Embryo Transfer: A Retrospective Cohort Study. BMC Pregnancy Childbirth, 21, Article No. 341. [Google Scholar] [CrossRef] [PubMed]
[25] Liu, X., Wang, H., Pan, R., et al. (2021) Comparison of the Method of Endometrial Preparation Prior to Frozen-Thawed Embryo Transfer: A Retrospective Cohort Study from 9733 Cycles. Reproductive Sciences, 28, 3155-3163. [Google Scholar] [CrossRef] [PubMed]
[26] Tuovinen, S., Räikkönen, K., Pesonen, A.K., et al. (2012) Hypertensive Disorders in Pregnancy and Risk of Severe Mental Disorders in the Offspring in Adulthood: The Helsinki Birth Cohort Study. Journal of Psychiatric Research, 46, 303-310. [Google Scholar] [CrossRef] [PubMed]
[27] Spiegel, E., Shoham-Vardi, I., Sergienko, R., et al. (2019) The Association between Birth Weight at Term and Long-Term Endocrine Morbidity of the Offspring. The Journal of Maternal-Fetal & Neonatal Medicine, 32, 2657-2661. [Google Scholar] [CrossRef] [PubMed]
[28] Baran, J., Weres, A., Baran, R., et al. (2022) Preterm Birth and the Type of Birth and Their Impact on the Incidence of Overweight and Obesity in Children. International Journal of Environmental Research and Public Health, 19, Article No. 12042. [Google Scholar] [CrossRef] [PubMed]
[29] Paz Levy, D., Sheiner, E., Wainstock, T., et al. (2017) Evidence That Children Born at Early Term (37-38 6/7 Weeks) are at Increased Risk for Diabetes and Obesity-Related Disorders. American Journal of Obstetrics & Gynecology, 217, 588.e1-588.e11. [Google Scholar] [CrossRef] [PubMed]

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