GRP78在消化道肿瘤的研究进展
Research Progress of GRP78 in Gastrointestinal Cancer
DOI: 10.12677/ACM.2022.12121647, PDF,    科研立项经费支持
作者: 张旭升, 孟 云, 郭辉军, 彭江山：甘肃中医药大学第一临床医学院，甘肃 兰州；关同闻, 阎于珂*：甘肃省人民医院普外二科，甘肃 兰州；杜雪芹：宁夏医科大学临床医学院，宁夏 银川
关键词: GRP78；消化道肿瘤；诊断；研究进展；GRP78； Gastrointestinal Cancer； Diagnosis； Research Progress
摘要: 消化道肿瘤我国是常见的恶性肿瘤，主要是指发生在食管、胃、结直肠、肝等的肿瘤。葡萄糖调节蛋白78 (Glucoregulatory protein 78, GRP78)又称免疫球蛋白重链结合蛋白，作为热休克蛋白70 (Heat shock protein 70, HSP70)家族的成员之一，存在于所有真核生物的内质网膜上。近些年来，大量研究表明GRP78在消化道肿瘤(如食管癌、胃癌、肝癌、结直肠癌等)的进展中具有潜在调控作用，且GRP78高表达通常与肿瘤患者的临床病理特征密切相关。此外，消化道肿瘤中GRP78可产生化学耐药性并且GRP78的表达和患者预后存在着一定的关系。本文主要针对GRP78在消化道肿瘤中的功能及其调控机制作一综述，为GRP78作为消化道肿瘤诊断、治疗及评估预后的生物靶标提供理论依据。
Abstract: Gastrointestinal tumor is a common malignant tumor in China, which mainly refers to the tumors occurring in the esophagus, stomach, colorectal, liver and so on. Glucoregulatory protein 78 (GRP78), also known as immunoglobulin heavy chain binding protein as a member of the heat shock protein 70 (HSP70) family, exists on the endoplasmic reticulum membrane of all eukaryotes. In recent years, a large number of studies have shown that GRP78 has a potential regulatory role in the progression of gastrointestinal tumors (such as esophageal cancer, gastric cancer, liver cancer, colorectal cancer, etc.), and the high expression of GRP78 is usually closely related to the clinicopathological characteristics of tumor patients. In addition, GRP78 can produce chemoresistance in gastrointestinal tumors, and there is a certain relationship between the ex-pression of GRP78 and the prognosis of patients. This article mainly reviews the function and reg-ulatory mechanism of GRP78 in gastrointestinal tumors, and provides theoretical basis for GRP78 as a biological target for diagnosis, treatment and prognosis evaluation of gastrointestinal tumors.
文章引用：张旭升, 关同闻, 孟云, 郭辉军, 彭江山, 杜雪芹, 阎于珂. GRP78在消化道肿瘤的研究进展[J]. 临床医学进展, 2022, 12(12): 11430-11440. https://doi.org/10.12677/ACM.2022.12121647

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