SOX4在胃癌中的研究进展
Research Progress of SOX4 in Gastric Cancer
DOI: 10.12677/ACM.2022.12121648, PDF,    科研立项经费支持
作者: 张旭升, 孟 云, 郭辉军, 彭江山：甘肃中医药大学第一临床医学院，甘肃 兰州；甘肃省人民医院普外二科，甘肃 兰州；杜雪芹：甘肃省人民医院普外二科，甘肃 兰州；宁夏医科大学临床医学院，宁夏 银川；阎于珂*：甘肃省人民医院普外二科，甘肃 兰州
关键词: SOX4；胃癌；机制；研究进展；SOX4； Gastric Cancer； Mechanism； Research Progress
摘要: 转录因子Y染色体上的性别决定区相关高迁移率族盒蛋白4 (sex-dertermining region of Y chromo-some related high mobility group box 4, SOX4)是SOX (SRY-box transcription factor)家族C亚群的成员，越来越多的报道称SOX4可能参与胃癌的发生及发展。研究表明，SOX4在胃癌组织中呈高表达，且SOX4的表达与胃癌的分化程度、临床分期、淋巴结转移等相关。同时，有研究表明SOX4可抑制胃癌细胞的增殖侵袭、影响患者的预后等，故SOX4有望成为胃癌肿瘤治疗的新靶点。本文就SOX4在胃癌中的作用及相关机制进行综述。
Abstract: Sex-determining region of Y chromosome related high mobility group box 4 (SOX4) is a member of subgroup C of SOX (SRY-box transcription factor) family, more and more reports suggest that SOX4 may be involved in the occurrence and development of gastric cancer. Studies have shown that SOX4 is highly expressed in gastric cancer tissues, and the expression of SOX4 is related to the de-gree of differentiation, clinical stage, and lymph node metastasis of gastric cancer. At the same time, studies have shown that SOX4 can inhibit the proliferation and invasion of gastric cancer cells and affect the prognosis of patients, so SOX4 is expected to become a new target for gastric cancer tumor therapy. This article reviews the role and related mechanisms of SOX4 in gastric cancer.
文章引用：张旭升, 孟云, 郭辉军, 彭江山, 杜雪芹, 阎于珂. SOX4在胃癌中的研究进展[J]. 临床医学进展, 2022, 12(12): 11441-11450. https://doi.org/10.12677/ACM.2022.12121648

参考文献

[1] Diamantis, A., Samara, A.A., Baloyiannis, I., et al. (2021) Gastrointestinal Stromal Tumor (GIST) and Synchronous Intra-Abdominal Liposarcoma: A Report of Two Rare Cases and Literature Review. International Journal of Surgical Oncology, 2021, Article ID: 2626635. [Google Scholar] [CrossRef] [PubMed]
[2] Etemadi, A., Safiri, S., Sepanlou, S.G., et al. (2020) The Global, Regional, and National Burden of Stomach Cancer in 195 Countries, 1990-2017: A Systematic Analysis for the Global Burden of Disease Study 2017. The Lancet Gastroenterology & Hepatology, 5, 42-54. [Google Scholar] [CrossRef] 
[3] Kole, C., Charalampakis, N., Tsakatikas, S., et al. (2021) Immunotherapy for Gastric Cancer: A 2021 Update. Immunotherapy, 14, 41-64. [Google Scholar] [CrossRef] [PubMed]
[4] Chen, J., Ju, H.L., Yuan, X.Y., Wang, T.J. and Lai, B.Q. (2016) SOX4 Is a Potential Prognostic Factor in Human Cancers: A Systematic Review and Meta-Analysis. Clinical and Translational Oncology, 18, 65-72. [Google Scholar] [CrossRef] [PubMed]
[5] 冀建波. 148份胃癌组织中SOX4和EZH2的表达及临床意义[J]. 中国药物与临床, 2019, 19(12): 1975-1977.
[6] Xu, G., Meng, Y., Wang, L., et al. (2021) MiRNA-214-5p In-hibits Prostate Cancer Cell Proliferation by Targeting SOX4. World Journal of Surgical Oncology, 19, Article No. 338. [Google Scholar] [CrossRef] [PubMed]
[7] Zhang, J., Xiao, C., Feng, Z., et al. (2020) SOX4 Promotes the Growth and Metastasis of Breast Cancer. Cancer Cell International, 20, Article No. 468. [Google Scholar] [CrossRef] [PubMed]
[8] Chen, Z., Zhong, T., Zhong, J., et al. (2021) MicroRNA-129 Inhibits Colorectal Cancer Cell Proliferation, Invasion and Epithelial-to-Mesenchymal Transition by Targeting SOX4. Oncology Reports, 45, Article No. 61. [Google Scholar] [CrossRef] [PubMed]
[9] Xu, X., Zong, K., Wang, X., et al. (2021) MiR-30d Suppresses Prolif-eration and Invasiveness of Pancreatic Cancer by Targeting the SOX4/PI3K-AKT Axis and Predicts Poor Outcome. Cell Death & Disease, 12, Article No. 350. [Google Scholar] [CrossRef] [PubMed]
[10] Peng, X., Liu, G., Peng, H., et al. (2018) Corrigendum to “SOX4 Contributions to TGF-β-Induced Endothelial-Mesenchymal Transition and Stem Cell Characteristics of Gastric Cancer Cells” [Genes & Diseases 5 (2018) 49-61]. Genes & Diseases, 8, 946-948. [Google Scholar] [CrossRef] [PubMed]
[11] Ikushima, H., Todo, T., Ino, Y., et al. (2011) Glioma-Initiating Cells Retain Their Tumorigenicity through Integration of the Sox Axis and Oct4 Protein. Journal of Biological Chemistry, 286, 41434-41441. [Google Scholar] [CrossRef] 
[12] Vervoort, S.J., Lourenco, A.R., Van Boxtel, R. and Coffer, P.J. (2013) SOX4 Mediates TGF-β-Induced Expression of Mesenchymal Markers during Mammary Cell Epithelial to Mesenchymal Transition. PLOS ONE, 8, e53238. [Google Scholar] [CrossRef] [PubMed]
[13] Wang, Q., Mao, X., Luo, F. and Wang, J. (2021) LINC00511 Promotes Gastric Cancer Progression by Regulating SOX4 and Epigenetically Repressing PTEN to Activate PI3K/AKT Pathway. Journal of Cellular and Molecular Medicine, 25, 9112-9127. [Google Scholar] [CrossRef] [PubMed]
[14] Gao, L.F., Li, W., Liu, Y.G., et al. (2021) Inhibition of MIR4435-2HG on Invasion, Migration, and EMT of Gastric Carcinoma Cells by Mediating MiR-138-5p/Sox4 Axis. Frontiers in On-cology, 11, Article ID: 661288. [Google Scholar] [CrossRef] [PubMed]
[15] 张健锋, 胡学群, 丁伟峰, 等. CDX2和SOX4在胃癌组织中的表达及临床意义[J]. 南通大学学报(医学版), 2019, 39(2): 85-88.
[16] Fang, C.L., Hseu, Y.C., Lin, Y.F., et al. (2012) Clinical and Prognostic Association of Transcription Factor SOX4 in Gastric Cancer. PLOS ONE, 7, e52804. [Google Scholar] [CrossRef] [PubMed]
[17] Yuan, X., Wang, S., Liu, M., et al. (2017) Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients. BioMed Research International, 2017, Article ID: 6894675. [Google Scholar] [CrossRef] [PubMed]
[18] Xia, G., Wang, A. and Li, L. (2022) Hsa_Circ_0000218/Hsa-miR-139-3p/SOX4 Regulatory Feedback Circuit Influences the Proliferation and Apoptosis of Gastric Cancer Cells. Cytotechnology, 74, 89-98. [Google Scholar] [CrossRef] [PubMed]
[19] Liu, L., Dai, A., Zhang, Z., et al. (2021) LncRNA PITPNA-AS1 Promotes Gastric Cancer by Increasing SOX4 Expression via Inhibition of miR-92a-3p. Aging, 13, 21191-21201. [Google Scholar] [CrossRef] [PubMed]
[20] Zhang, J., Zhang, K. and Hou, Y. (2020) Long Non-Coding RNA NNT-AS1 Knockdown Represses the Progression of Gastric Cancer via Modulating the miR-142-5p/SOX4/Wnt/β-Catenin Signaling Pathway. Molecular Medicine Reports, 22, 687-696. [Google Scholar] [CrossRef] [PubMed]
[21] Dong, X., Chen, R., Lin, H., Lin, T. and Pan, S. (2018) LncRNA BG981369 Inhibits Cell Proliferation, Migration, and Invasion, and Promotes Cell Apoptosis by SRY-Related High-Mobility Group Box 4 (SOX4) Signaling Pathway in Human Gastric Cancer. Medical Science Monitor, 24, 718-726. [Google Scholar] [CrossRef] 
[22] Pang, L., Li, B., Zheng, B., Niu, L. and Ge, L. (2017) MiR-138 Inhibits Gastric Cancer Growth by Suppressing SOX4. Oncology Reports, 38, 1295-1302. [Google Scholar] [CrossRef] [PubMed]
[23] Wang, C.Y., Hua, L., Sun, J., et al. (2015) MiR-211 Inhibits Cell Pro-liferation and Invasion of Gastric Cancer by Down-Regulating SOX4. International Journal of Clinical and Experi-mental Pathology, 8, 14013-14020.
[24] Shao, J.P., Su, F., Zhang, S.P., et al. (2020) MiR-212 as Potential Biomarker Suppresses the Proliferation of Gastric Cancer via Targeting SOX4. Journal of Clinical Laboratory Analysis, 34, e23511. [Google Scholar] [CrossRef] [PubMed]
[25] Zou, J. and Xu, Y. (2016) MicroRNA-140 Inhibits Cell Proliferation in Gastric Cancer Cell Line HGC-27 by Suppressing SOX4. Medical Science Monitor, 22, 2243-2252. [Google Scholar] [CrossRef] 
[26] Zhao, X., Zheng, F., Li, Y., et al. (2019) BPTF Promotes Hepatocel-lular Carcinoma Growth by Modulating hTERT Signaling and Cancer Stem Cell Traits. Redox Biology, 20, 427-441. [Google Scholar] [CrossRef] [PubMed]
[27] Ding, L., Zhao, Y., Dang, S., et al. (2019) Circular RNA Circ-DONSON Facilitates Gastric Cancer Growth and Invasion via NURF Complex Dependent Activation of Tran-scription Factor SOX4. Molecular Cancer, 18, Article No. 45. [Google Scholar] [CrossRef] [PubMed]
[28] Liu, L., Dong, T. and Sheng, J. (2021) Propofol Suppresses Gas-tric Cancer Progression by Regulating circPDSS1/miR- 1324/SOX4 Axis. Cancer Management and Research, 13, 6031-6043. [Google Scholar] [CrossRef] 
[29] Sun, Y. and Han, C. (2020) Long Non-Coding RNA TMPO-AS1 Promotes Cell Migration and Invasion by Sponging miR-140-5p and Inducing SOX4-Mediated EMT in Gastric Cancer. Cancer Management and Research, 12, 1261-1268. [Google Scholar] [CrossRef] 
[30] 马萌. 表观遗传定义的肿瘤微环境及其中医证本质[J]. 中华中医药杂志, 2020, 35(6): 2987-2994.
[31] Shen, R., Pan, S., QI, S., Lin, S. and Cheng, S. (2010) Epigenetic Repression of microRNA-129-2 Leads to Overexpression of SOX4 in Gastric Cancer. Biochemical and Biophysical Research Communications, 394, 1047-1052. [Google Scholar] [CrossRef] [PubMed]
[32] Chen, Y., Gong, W., Dai, W., et al. (2020) MiR-596 down Regu-lates SOX4 Expression and Is a Potential Novel Biomarker for Gastric Cancer. Translational Cancer Research, 9, 1294-1302. [Google Scholar] [CrossRef] [PubMed]
[33] Weng, J., Wu, A. and Ying, J. (2022) Chemosensitivity of Gastric Cancer: Analysis of Key Pathogenic Transcription Factors. Journal of Gastrointestinal Oncology, 13, 977-984. [Google Scholar] [CrossRef] [PubMed]
[34] Schilham, M.W., Oosterwegel, M.A., Moerer, P., et al. (1996) Defects in Cardiac Outflow Tract Formation and Pro-B-Lymphocyte Expansion in Mice Lacking Sox-4. Nature, 380, 711-714. [Google Scholar] [CrossRef] [PubMed]
[35] Cheung, M., Abu-Elmagd, M., Clevers, H. and Scotting, P.J. (2000) Roles of Sox4 in Central Nervous System Development. Molecular Brain Research, 79, 180-190. [Google Scholar] [CrossRef] 
[36] Tsai, C.N., Yu, S.C., Lee, C.W., et al. (2020) SOX4 Acti-vates CXCL12 in Hepatocellular Carcinoma Cells to Modulate Endothelial Cell Migration and Angiogenesis in Vivo. Oncogene, 39, 4695-4710. [Google Scholar] [CrossRef] [PubMed]
[37] Moran, J.D., Kim, H.H., Li, Z. and Moreno, C.S. (2019) SOX4 Regulates Invasion of Bladder Cancer Cells via Repression of WNT5a. International Journal of Oncology, 55, 359-370. [Google Scholar] [CrossRef] [PubMed]
[38] Wang, B., Li, Y., Tan, F. and Xiao, Z. (2016) Increased Expression of SOX4 Is Associated with Colorectal Cancer Progression. Tumor Biology, 37, 9131-9137. [Google Scholar] [CrossRef] [PubMed]
[39] Cheng, Q., Du, J., Xie, L., et al. (2018) Inhibition of SOX4 In-duces Melanoma Cell Apoptosis via Downregulation of NF-κB p65 Signaling. Oncology Reports, 40, 369-376. [Google Scholar] [CrossRef] [PubMed]
[40] Sun, R., Jiang, B., Qi, H., et al. (2015) SOX4 Contributes to the Pro-gression of Cervical Cancer and the Resistance to the Chemotherapeutic Drug through ABCG2. Cell Death & Disease, 6, e1990. [Google Scholar] [CrossRef] [PubMed]

为你推荐