白蛋白结合型紫杉醇治疗胃癌的研究进展
Research Progress of Albumin-Bound Paclitaxel for Gastric Cancer
DOI: 10.12677/ACM.2022.12121662, PDF,   
作者: 冯 龙:青海大学研究生院,青海 西宁;才保加*:青海大学附属肿瘤医院肿瘤外科,青海 西宁;李忠兴:潼关县人民医院,陕西 渭南
关键词: 胃癌白蛋白结合型紫杉醇综述文献Gastric Cancer Albumin-Bound Paclitaxel Review of Literature
摘要: 胃癌在我国的发病率和死亡率均较高,手术、放疗和化疗为胃癌的标准治疗方法,尽管取得了明显的临床获益,但胃癌的总体预后仍很差。化疗可以在一定程度上延缓肿瘤的进展,延长患者的生存时间,纳米粒白蛋白紫杉醇是由白蛋白与紫杉醇结合形成,主要通过抑制细胞分裂,从而达到杀灭肿瘤细胞的目的,具有抗肿瘤效果好、给药方便、药物副作用低等优点,因此近年来关于白蛋白结合紫杉醇在胃癌治疗中的应用,广泛开展了基础和临床研究。本文就白蛋白结合型紫杉醇在胃癌治疗中的研究进展进行综述。
Abstract: Gastric cancer has a high morbidity and mortality rate in China, and surgery, radiotherapy and chemotherapy are the standard treatments for gastric cancer; despite the obvious clinical benefits achieved, the overall prognosis of gastric cancer is still poor. Chemotherapy can delay the pro-gression of tumor and prolong the survival time of patients to a certain extent, and nanoparticle albumin paclitaxel is formed by combining albumin and paclitaxel, mainly by inhibiting cell divi-sion, thus achieving the purpose of killing tumor cells, which has the advantages of good anti-tumor effect, convenient administration and low drug side effects, therefore, in recent years, the application of albumin combined with paclitaxel in the treatment of gastric cancer has been widely carried out. In this paper, we have discussed the application of albumin-conjugated paclitaxel in the treatment of gastric cancer. In this paper, we review the research progress of albumin-bound paclitaxel in the treatment of gastric cancer.
文章引用:冯龙, 才保加, 李忠兴. 白蛋白结合型紫杉醇治疗胃癌的研究进展[J]. 临床医学进展, 2022, 12(12): 11528-11533. https://doi.org/10.12677/ACM.2022.12121662

参考文献

[1] Cheng, X., et al. (2021) Adjuvant Albumin-Bound Paclitaxel Combined with S-1 vs. Oxaliplatin Combined with Capecitabine after D2 Gastrectomy in Patients with Stage III Gastric Adenocarcinoma: A Phase III Multicenter, Open-Label, Randomized Controlled Clinical Trial Protocol. BMC Cancer, 21, Article No. 56. [Google Scholar] [CrossRef] [PubMed]
[2] Ajani, J.A., et al. (2013) Gastric Cancer, Version 2.2013. Journal of the National Comprehensive Cancer Network, 11, 531-546.
[3] 吕豪. 局部进展期胃癌新辅助化疗临床疗效评估及相关影响因素分析[D]: [硕士学位论文]. 开封: 河南大学, 2020.[CrossRef
[4] Isobe, Y., et al. (2011) Gastric Cancer Treatment in Japan: 2008 Annual Report of the JGCA Nationwide Registry. Gastric Cancer, 14, 301-316. [Google Scholar] [CrossRef] [PubMed]
[5] He, M., et al. (2018) Phase II Clinical Trial of S-1 plus Nanopar-ticle Albumin-Bound Paclitaxel in Untreated Patients with Metastatic Gastric Cancer. Cancer Science, 109, 3575-3582. [Google Scholar] [CrossRef] [PubMed]
[6] Shitara, K., et al. (2017) Nab-Paclitaxel versus Solvent-Based Paclitaxel in Patients with Previously Treated Advanced Gastric Cancer (ABSOLUTE): An Open-Label, Randomised, Non-Inferiority, Phase 3 Trial. The Lancet Gastroenterology & Hepatology, 2, 277-287. [Google Scholar] [CrossRef
[7] Katsaounis, P. (2017) Nab-Paclitaxel as Second-Line Treatment in Advanced Gastric Cancer: A Multicenter Phase II Study of the Hellenic Oncology Research Group. Annals of Gastroenterology, 31, 65-70. [Google Scholar] [CrossRef] [PubMed]
[8] Bando, H., et al. (2018) A Phase II Study of Nab-Paclitaxel in Combination with Ramucirumab in Patients with Previously Treated Advanced Gastric Cancer. European Journal of Cancer, 91, 86-91. [Google Scholar] [CrossRef] [PubMed]
[9] Kawamoto, Y., et al. (2017) Study Protocol of HGCSG1404 SNOW Study: A Phase I/II Trial of Combined Chemotherapy of S-1, Nab-Paclitaxel and Oxaliplatin Administered Bi-weekly to Patients with Advanced Gastric Cancer. BMC Cancer, 17, Article No. 837. [Google Scholar] [CrossRef] [PubMed]
[10] Ford, H.E.R., et al. (2014) Docetaxel versus Active Symptom Control for Refractory Oesophagogastric Adenocarcinoma (COUGAR-02): An Open-Label, Phase 3 Randomised Controlled Trial. The Lancet Oncology, 15, 78-86. [Google Scholar] [CrossRef
[11] Roviello, G., et al. (2019) Nanoparticle Albumin-Bound Paclitaxel: A Big Nano for the Treatment of Gastric Cancer. Cancer Chemotherapy and Pharmacology, 84, 669-677. [Google Scholar] [CrossRef] [PubMed]
[12] Gelderblom, H., Verweij, J., Nooter, K. and Sparreboom, A. (2001) Cremophor EL: The Drawbacks and Advantages of Vehicle Selection for Drug Formulation. European Journal of Cancer, 37, 1590-158. [Google Scholar] [CrossRef
[13] Hidalgo, M., et al. (2015) SPARC Expression Did Not Predict Efficacy of Nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Ex-ploratory Analysis of the Phase III MPACT Trial. Clinical Cancer Research, 21, 4811-4818. [Google Scholar] [CrossRef
[14] Desai, N., Trieu, V., Damascelli, B. and Soon-Shiong, P. (2009) SPARC Expression Correlates with Tumor Response to Albumin-Bound Paclitaxel in Head and Neck Cancer Patients. Translational Oncology, 2, 59-64. [Google Scholar] [CrossRef] [PubMed]
[15] Schettini, F., Giuliano, M., De Placido, S. and Arpino, G. (2016) Nab-Paclitaxel for the Treatment of Triple-Negative Breast Cancer: Rationale, Clinical Data and Future Perspectives. Cancer Treatment Reviews, 50, 129-141. [Google Scholar] [CrossRef] [PubMed]
[16] ten Tije, A.J., Verweij, J., Loos, W.J. and Sparreboom, A. (2003) Pharmacological Effects of Formulation Vehicles: Implications for Cancer Chemotherapy. Clinical Pharmacokinetics, 42, 665-685. [Google Scholar] [CrossRef] [PubMed]
[17] Gradishar, W.J., et al. (2005) Phase III Trial of Nano-particle Albumin-Bound Paclitaxel Compared with Polyethylated Castor Oil-Based Paclitaxel in Women with Breast Cancer. JCO, 23, 7794-7803. [Google Scholar] [CrossRef
[18] Desai, N., et al. (2006) Increased Antitumor Activity, Intratumor Paclitaxel Concentrations, and Endothelial Cell Transport of Cremophor-Free, Albumin-Bound Paclitaxel, ABI-007, Compared with Cremophor-Based Paclitaxel. Clinical Cancer Research, 12, 1317-1324. [Google Scholar] [CrossRef
[19] Gardner, E.R., et al. (2008) Randomized Crossover Phar-macokinetic Study of Solvent-Based Paclitaxel and Nab-Paclitaxel. Clinical Cancer Research, 14, 4200-4205. [Google Scholar] [CrossRef
[20] Watson, S., et al. (2019) Oxaliplatin, 5-Fluorouracil and Nab-Paclitaxel as Perioperative Regimen in Patients with Resectable Gastric Adenocarcinoma: A GERCOR Phase II Study (FOXAGAST). European Journal of Cancer, 107, 46-52. [Google Scholar] [CrossRef] [PubMed]
[21] Nakamura, M., et al. (2021) Phase 1 Study of Combined of Nab-Paclitaxel, S-1, and Oxaliplatin for Gastric Cancer with Peritoneal Metastasis (NSOX Study). Oncology, 99, 57-61. [Google Scholar] [CrossRef] [PubMed]
[22] Sasaki, Y., et al. (2014) Phase II Trial of Nanoparticle Albumin-Bound Paclitaxel as Second-Line Chemotherapy for Unresectable or Recurrent Gastric Cancer. Cancer Science, 105, 812-817. [Google Scholar] [CrossRef] [PubMed]
[23] Ibrahim, N.K., et al. (2005) Multicenter Phase II Trial of ABI-007, an Albumin-Bound Paclitaxel, in Women with Metastatic Breast Cancer. JCO, 23, 6019-6026. [Google Scholar] [CrossRef
[24] Sato, S., et al. (2018) A Phase II Study of Tri-Weekly Low-Dose Nab-Paclitaxel Chemotherapy for Patients with Advanced Gastric Cancer. Anticancer Research, 38, 6911-6917. [Google Scholar] [CrossRef] [PubMed]
[25] Xiong, J., Han, S., Ding, S., He, J. and Zhang, H. (2018) Anti-body-Nanoparticle Conjugate Constructed with Trastuzumab and Nanoparticle Albumin-Bound Paclitaxel for Targeted Therapy of Human Epidermal Growth Factor Receptor 2-Positive Gastric Cancer. Oncology Reports, 39, 1396-1404. [Google Scholar] [CrossRef] [PubMed]