铁死亡在糖尿病及其相关并发症中的研究进展
Research Progress of Ferroptosis in Diabetes Mellitus and Related Complications
DOI: 10.12677/ACM.2022.12121688, PDF,    科研立项经费支持
作者: 郭 巧*, 彭 冉, 高 韬, 柯大智#：重庆医科大学附属第二医院全科医学科，重庆
关键词: 铁死亡；糖尿病；糖尿病相关并发症 ；Ferroptosis； Diabetes Mellitus； Diabetes-Related Complications
摘要: 铁死亡作为一种近年新发现的细胞死亡形式，以铁积累和脂质过氧化为基本特征，被大量研究证实参与肿瘤、动脉粥样硬化、神经退行性疾病、组织缺血再灌注损伤等多种疾病的病理过程。糖尿病及其相关并发症的发生发展涉及脂质氧化应激、炎症激活等多种病理过程，因此近年来铁死亡与糖尿病及其相关并发症的关系被不断探索。本文综述了近年铁死亡在糖尿病及其相关并发症中的研究，以期为糖尿病及其相关并发症发病机制的进一步探索和治疗提供新的方向。
Abstract: Ferroptosis, a newly discovered form of cell death in recent years, is characterized by iron accu-mulation and lipid peroxidation, and has been confirmed by numerous studies to be involved in the pathological processes of various diseases such as tumors, atherosclerosis, neurodegenerative diseases, and tissue ischemia-reperfusion injury. The occurrence and development of diabetes mellitus and its related complications involves various pathological processes such as lipid oxida-tive stress and inflammatory activation, therefore the relationship between ferroptosis and dia-betes mellitus and its related complications has been continuously explored in recent years. This paper reviews the recent studies on ferroptosis in diabetes and its related complications, with the aim of providing new directions for further exploration of the pathogenesis and treatment of dia-betes and its related complications.
文章引用：郭巧, 彭冉, 高韬, 柯大智. 铁死亡在糖尿病及其相关并发症中的研究进展[J]. 临床医学进展, 2022, 12(12): 11720-11726. https://doi.org/10.12677/ACM.2022.12121688

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