HIF-1α表达与创伤性颅脑损伤预后关系的研究

Study on the Relationship between the Expression of HIF-1α and the Prognosis of Traumatic Brain Injury

摘要: 创伤性颅脑损伤(traumatic brain injury, TBI)是世界范围内死亡和残疾的主要原因之一。在过去的几十年里，人们对TBI后组织损伤发展的相关机制进行了广泛的研究，越来越明显的是，脑水肿(cerebral edema, CE)的形成是导致TBI患者高死亡率和发病率的主要因素之一。出血灶脑组织缺血缺氧，造成细胞凋亡，并且周围脑组织受压，导致脑水肿形成并在发病后第3天达高峰，最终严重影响患者预后。有研究表明氧感知通路的缺氧诱导因子-1α (hypoxia inducible factor-1, HIF-1α)通过一种放大作用促进HIF-1α下游miR-21通路激活，最终miR-2通过抑制PTEN的表达和促进Tie-2表达，促进血管重建，继而加快血肿吸收，阻止水肿进展，最终改善TBI患者的神经功能预后。因此，我们就TBI后引起CE的氧感知通路作一综述，研究HIF-1α的表达对TBI患者预后具有重要意义。

Abstract: Traumatic brain injury (TBI) is one of the major causes of death and disability worldwide. In the past decades, people have conducted extensive research on the mechanism of tissue damage de-velopment after TBI. It is increasingly obvious that the formation of cerebral edema (CE) is one of the main factors leading to the high mortality and incidence rate of TBI patients. Ischemia and hypoxia in the brain tissue of the hemorrhage focus lead to apoptosis, and the surrounding brain tissue is compressed, leading to the formation of cerebral edema and reaching the peak on the third day after the onset, which ultimately seriously affects the prognosis of patients. Studies have shown that oxygen sensitive pathway HIF-1α promotes HIF-1 through amplification effect α. The downstream miR-21 pathway is activated, and finally miR-2 promotes vascular reconstruction by inhibiting PTEN expression and promoting Tie-2 expression, and then accelerate the absorption of hematoma, prevent the progress of edema, and finally improve the neurological prognosis of TBI patients. Therefore, we describe the oxygen sensing pathway that induces CE after TBI in summary, it is important to study the expression of HIF-1α for the prognosis of patients with TBI.