γδT细胞在脓毒症免疫功能紊乱的研究进展
Research Progress of γδT Cells in Immune Dysfunction of Sepsis
DOI: 10.12677/ACM.2022.12121700, PDF,   
作者: 金 笾, 许 峰*:重庆医科大学附属儿童医院,重庆
关键词: γδT细胞脓毒症免疫功能紊乱γδT Cells Sepsis Immune Dysfunction
摘要: 近年来对脓毒症患者免疫功能紊乱机制的研究日渐受到重视,机体的免疫系统状态与脓毒症的发生、发展及其预后有着密切的利害关系。γδT细胞具备先天性免疫和获得性免疫的双重特点,逐步发现其参与脓毒症的病理生理的整个过程。因此,本文综述γδT细胞在脓毒症中的研究进展,以期探讨γδT细胞在脓毒症病理状态下的免疫反应机制,为以γδT细胞为靶点的免疫支持治疗提供方向。
Abstract: In recent years, the research on the mechanism of immune dysfunction in sepsis patients has been paid more and more attention seriously. The state of immune system is closely related to the de-velopment and prognosis of sepsis. γδT cells have the dual characteristics of innate-immunity and acquired-immunity, and are gradually found to be closely bound up with the pathophysiological whole process of sepsis. Therefore, this article is mainly focused on the immunologic mechanism of γδT cells in the pathological state of sepsis, aiming at providing theoretical directions for γδT cells-targeted supportive immunotherapy.
文章引用:金笾, 许峰. γδT细胞在脓毒症免疫功能紊乱的研究进展[J]. 临床医学进展, 2022, 12(12): 11806-11811. https://doi.org/10.12677/ACM.2022.12121700

参考文献

[1] Van Der Poll, T., Shankar-Hari, M. and Wiersinga, W.J. (2021) The Immunology of Sepsis. Immunity, 54, 2450-2464. [Google Scholar] [CrossRef] [PubMed]
[2] Andreu-Ballester, J.C., Arribas, M.A., Rico, M., et al. (2022) Changes of CD3+CD56+ γδ T Cell Number and Apoptosis during Hospital Admission Are Related to Mortality in Sep-tic Patients. Clinical Immunology, 236, Article ID: 108956. [Google Scholar] [CrossRef] [PubMed]
[3] Khairallah, C., Chu, T.H. and Sheridan, B.S. (2018) Tissue Adap-tations of Memory and Tissue-Resident Gamma Delta T Cells. Frontiers in Immunology, 9, Article 2636. [Google Scholar] [CrossRef] [PubMed]
[4] Jensen, I.J., Sjaastad, F.V., Griffith, T.S. and Badovinac, V.P. (2018) Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity. Journal of Immunology, 200, 1543-1553.
[5] Kreslavsky, T., Gleimer, M., Garbe, A.I. and Von Boehmer, H. (2010) αβ versus γδ Fate Choice: Counting the T-Cell Lineages at the Branch Point. Immunological Reviews, 238, 169-181. [Google Scholar] [CrossRef
[6] Lalor, S.J. and McLoughlin, R.M. (2016) Memory γδ T Cells—Newly Appreciated Protagonists in Infection and Immunity. Trends in Immunology, 37, 690-702. [Google Scholar] [CrossRef] [PubMed]
[7] Andreu-Ballester, J.C., Zamora, V., Garcia-Ballesteros, C., et al. (2018) Anti-Anisakis sp. Antibodies in Serum of Patients with Sepsis and Their Relationship with γδ T Cells and Disease Severity. International Journal for Parasitology, 48, 483-491. [Google Scholar] [CrossRef] [PubMed]
[8] Rigau, M., Ostrouska, S., Fulford, T.S., et al. (2020) Butyrophilin 2A1 Is Essential for Phosphoantigen Reactivity by γδ T Cells. Science, 367, eaay5516. [Google Scholar] [CrossRef] [PubMed]
[9] Lin, L., Chen, Y., Chen, D., et al. (2022) Transient 40˚C-Shock Po-tentiates Cytotoxic Responses of Vδ2+ γδ T Cell via HSP70 Upregulation. Cancer Immunology, Immunotherapy, 71, 2391-2404. [Google Scholar] [CrossRef] [PubMed]
[10] Tanaka, Y. (2020) Cancer Immunotherapy Harnessing γδ T Cells and Programmed Death-1. Immunological Reviews, 298, 237-253. [Google Scholar] [CrossRef] [PubMed]
[11] Woo, S.R., Corrales, L. and Gajewski, T.F. (2015) Innate Immune Recognition of Cancer. Annual Review of Immunology, 33, 445-474. [Google Scholar] [CrossRef] [PubMed]
[12] Mcginley, A.M., Edwards, S.C., Raverd-eau, M. and Mills, K.H.G. (2018) Th17 Cells, γδ T Cells and Their Interplay in EAE and Multiple Sclerosis. Journal of Autoimmunity, 87, 97-108. [Google Scholar] [CrossRef] [PubMed]
[13] Vantourout, P. and Hayday, A. (2013) Six-of-the-Best: Unique Contributions of γδ T Cells to Immunology. Nature Reviews Immunology, 13, 88-100. [Google Scholar] [CrossRef] [PubMed]
[14] Sabbione, F., Gabelloni, M.L., Ernst, G., et al. (2014) Neutrophils Suppress γδ T-Cell Function. European Journal of Immunology, 44, 819-830. [Google Scholar] [CrossRef] [PubMed]
[15] David, P.C., Mei-Ling, L., Tyler, L., et al. (2018) Gamma Delta T Cell Therapy for Cancer: It Is Good to Be Local. Frontiers in Immunology, 9, Article 1305. [Google Scholar] [CrossRef] [PubMed]
[16] Mangan, B.A., et al. (2013) Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human Vδ3 T Cells. Journal of Immunology, 191, 30-34. [Google Scholar] [CrossRef] [PubMed]
[17] Pinheiro, M.B., Antonelli, L.R., Sathler-Avelar, R., et al. (2012) CD4-CD8-αβ and γδ T Cells Display Inflammatory and Regulatory Potentials during Human Tuberculosis. PLOS ONE, 7, e50923. [Google Scholar] [CrossRef] [PubMed]
[18] Long, K.M., Ferris, M.T., Whitmore, A.C., et al. (2016) γδ T Cells Play a Protective Role in Chikungunya Virus-Induced Disease. Journal of Virology, 90, 433-443. [Google Scholar] [CrossRef
[19] Hirsh, M.I. and Junger, W.G. (2008) Roles of Heat Shock Proteins and γδT Cells in Inflammation. American Journal of Respiratory Cell and Molecular Biology, 39, 509-513. [Google Scholar] [CrossRef
[20] Barisa, M., Kramer, A.M., Majani, Y., et al. (2017) E. coli Pro-motes Human Vγ9Vδ2 T Cell Transition from Cytokine-Producing Bactericidal Effectors to Professional Phagocytic Killers in a TCR-Dependent Manner. Scientific Reports, 7, Article No. 2805. [Google Scholar] [CrossRef] [PubMed]
[21] Zhu, Y., Wang, H., Xu, Y., et al. (2016) Human γδ T Cells Augment Antigen Presentation in Listeria monocytogenes Infection. Molecular Medicine, 22, 737-746. [Google Scholar] [CrossRef] [PubMed]
[22] Mao, C., Mou, X., Zhou, Y., et al. (2014) Tumor-Activated TCRγδ+ T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of TCRαβ+ T Cells via Their An-tigen-Presenting Cell-Like Effects. Journal of Immunology Research, 2014, Article ID: 593562. [Google Scholar] [CrossRef] [PubMed]
[23] Rampoldi, F., Ullrich, L. and Prinz, I. (2020) Revisiting the Interaction of γδ T-Cells and B-Cells. Cells, 9, Article 743. [Google Scholar] [CrossRef] [PubMed]
[24] Ribot, J.C., Debarros, A. and Silva-Santos, B. (2011) Searching for “Signal 2”: Costimulation Requirements of γδ T Cells. Cellular and Molecular Life Sciences, 68, 2345-2355. [Google Scholar] [CrossRef] [PubMed]
[25] de Souza Costa, M.F., de Negreiros, C.B., Bornstein, V.U., et al. (2015) Murine IL-17+ Vγ4 T Lymphocytes Accumulate in the Lungs and Play a Protective Role during Severe Sepsis. BMC Immunology, 16, Article No. 36. [Google Scholar] [CrossRef] [PubMed]
[26] Tschöp, J., Martignoni, A., Goetzman, H.S., et al. (2008) γδ T Cells Mitigate the Organ Injury and Mortality of Sepsis. Journal of Leukocyte Biology, 83, 581-588. [Google Scholar] [CrossRef] [PubMed]
[27] Darden, D.B., Kelly, L.S., Fenner, B.P., et al. (2021) Dysregulated Im-munity and Immunotherapy after Sepsis. Journal of Clinical Medicine, 10, Article No. 1742. [Google Scholar] [CrossRef] [PubMed]
[28] Heffernan, D.S., Monaghan, S.F., Chung, C.S., Cioffi, W.G., Gravenstein, S. and Ayala, A. (2014) A Divergent Response of Innate Regulatory T-Cells to Sepsis in Humans: Circu-lating Invariant Natural Killer T-Cells Are Preserved. Human Immunology, 75, 277-282. [Google Scholar] [CrossRef] [PubMed]
[29] Andreu-Ballester, J.C., Tormo-Calandin, C., Gar-cia-Ballesteros, C., et al. (2013) Association of γδ T Cells with Disease Severity and Mortality in Septic Patients. Clinical and Vaccine Immunology, 20, 738-746. [Google Scholar] [CrossRef
[30] Douglas, J.J., Tsang, J.L.Y. and Walley, K.R. (2014) Sepsis and the Innate-Like Response. Intensive Care Medicine, 40, 249-251. [Google Scholar] [CrossRef] [PubMed]
[31] Wang, X., Li, W., Zhu, D., et al. (2020) Characterization of Hu-man Peripheral Blood γδ T Cells in Patients with Sepsis. Experimental and Therapeutic Medicine, 19, 3698-3706. [Google Scholar] [CrossRef] [PubMed]
[32] Sabbagh, P., Karkhah, A., Nouri, H.R., Javanian, M. and Ebrahimpour, S. (2018) The Significance Role of Regulatory T Cells in the Persistence of Infections by Intracellular Bacteria. Infection, Genetics and Evolution, 62, 270-274. [Google Scholar] [CrossRef] [PubMed]
[33] He, W., Xiao, K., Fang, M. and Xie, L. (2021) Immune Cell Number, Phenotype, and Function in the Elderly with Sepsis. Aging and Disease, 12, 277-296. [Google Scholar] [CrossRef
[34] Clohosey, M.L., Mann, B.T., Ryan, P.L., et al. (2020) Comparable Vδ2 Cell Functional Characteristics in Virally Suppressed People Living with HIV and Uninfected Individuals. Cells, 9, Article No. 2568. [Google Scholar] [CrossRef] [PubMed]
[35] Liu, J., Qu, H., et al. (2013) The Responses of γδ T-Cells against Acute Pseudomonas aeruginosa Pulmonary Infection in Mice via Interleukin-17. Pathogens and Disease, 68, 44-51. [Google Scholar] [CrossRef
[36] Wu, Y.L., Ding, Y.P., Tanaka, Y., et al. (2014) γδ T Cells and Their Potential for Immunotherapy. International Journal of Biological Sciences, 10, 119-135. [Google Scholar] [CrossRef] [PubMed]
[37] Liao, X.L., Feng, T., Zhang J Q, et al. (2017) Phenotypic Changes and Im-paired Function of Peripheral γδ T Cells in Patients with Sepsis. SHOCK, 48, 321-328. [Google Scholar] [CrossRef
[38] Galley, H.F., Lowes, D.A., Thompson, K., et al. (2015) Characterisation of Gamma Delta (γδ) T Cell Populations in Patients with Sepsis. Cell Biology International, 39, 210-216. [Google Scholar] [CrossRef] [PubMed]
[39] Yang, X.W., Li, H., Feng, T., et al. (2022) Impairment of Anti-gen-Presenting Function of Peripheral γδ T Cells in Patients with Sepsis. Clinical and Experimental Immunology, 207, 104-112. [Google Scholar] [CrossRef] [PubMed]
[40] Sacchi, A., Rinaldi, A., Tumino, N., et al. (2014) HIV Infection of Monocytes-Derived Dendritic Cells Inhibits Vγ9Vδ2 T Cells Functions. PLOS ONE, 9, e111095. [Google Scholar] [CrossRef] [PubMed]
[41] Chen, C.Y., Yao, S., Huang, D., et al. (2013) Phosphoanti-gen/IL2 Expansion and Differentiation of Vγ2Vδ2 T Cells Increase Resistance to Tuberculosis in Nonhuman Primates. PLOS Pathogens, 9, e1003501. [Google Scholar] [CrossRef] [PubMed]
[42] Ono, K., Onishi, Y., Kobayashi, M., et al. (2019) γδ T Cell Clonal Proliferation Early after PD-1 Blockade. Annals of Hematology, 98, 219-220. [Google Scholar] [CrossRef] [PubMed]
[43] Li, H. and Pauza, C.D. (2011) Rapamycin Increases the Yield and Effector Function of Human γδ T Cells Stimulated in Vitro. Cancer Immunology, Immunotherapy, 60, 361-370. [Google Scholar] [CrossRef] [PubMed]
[44] Kasten, K.R., Prakash, P.S., Unsinger, J., et al. (2010) Interleu-kin-7 (IL-7) Treatment Accelerates Neutrophil Recruitment through γδ T-Cell IL-17 Production in a Murine Model of Sepsis. Infection and Immunity, 78, 4714-4722. [Google Scholar] [CrossRef