自体牙的研究及应用进展
Research and Application Progress of Autogenous Teeth
DOI: 10.12677/ACM.2022.12121714, PDF,   
作者: 达尔亚·俄尼木拜*, 张 迪:新疆医科大学第一附属医院(附属口腔医院)牙周病科,新疆 乌鲁木齐;古丽努尔·阿吾提#:新疆医科大学第一附属医院(附属口腔医院)牙周病科,新疆 乌鲁木齐;新疆维吾尔自治区口腔医学研究所,新疆 乌鲁木齐
关键词: 自体牙自体牙骨粉脱矿牙本质基质骨移植材料骨修复Autogenous Tooth Autogenous Tooth Bone Powder Demineralized Dentin Matrix Bone Graft Mate-rials Bone Repair
摘要: 牙齿的结构在物理和生物化学上都与骨骼非常相似,利用牙齿作为自体骨移植的来源是一种创新和巧妙的技术,目前大量的临床及动物研究证明,自体牙在愈合潜力、物理特性和临床结果方面具有与植骨材料相似的特点,而本文就从自体牙成骨原理及相关影响因素、制备方法、临床与动物研究等方面阐述。
Abstract: The structure of teeth is very similar to bone in both physical and biochemical aspects. It is an in-novative and ingenious technology to use human teeth as the source of autologous bone transplan-tation. At present, a large number of clinical and animal studies have proved that autologous teeth have similar characteristics with bone graft materials in terms of healing potential, physical char-acteristics and clinical results. This paper focuses on the principle of autologous tooth osteogenesis and related influencing factors, preparation methods, clinical and animal studies are described.
文章引用:达尔亚·俄尼木拜, 张迪, 古丽努尔·阿吾提. 自体牙的研究及应用进展[J]. 临床医学进展, 2022, 12(12): 11894-11900. https://doi.org/10.12677/ACM.2022.12121714

参考文献

[1] Kim, S.Y., Kim, Y.K., Park, Y.H., et al. (2017) Evaluation of the Healing Potential of Demineralized Dentin Matrix Fixed with Recombinant Human Bone Morphogenetic Protein-2 in Bone Grafts. Materials (Basel), 10, Article No. 1049. [Google Scholar] [CrossRef] [PubMed]
[2] Zhu, G., Zhang, T., Chen, M., et al. (2021) Bone Physiological Microen-vironment and Healing Mechanism: Basis for Future Bone-Tissue Engineering Scaffolds. Bioactive Materials, 6, 4110-4140. [Google Scholar] [CrossRef] [PubMed]
[3] Yeomans, J.D. and Urist, M.R. (1967) Bone Induction by Decalcified Dentine Implanted into Oral, Osseous and Muscle Tissues. Archives of Oral Biology, 12, 999-1008. [Google Scholar] [CrossRef] [PubMed]
[4] 赵锐, 王译晗, 朱悦. 调控成骨细胞分化的信号通路及细胞因子研究进展[J]. 中国医学创新, 2021, 18(5): 171-175.
[5] Um, I.-W. (2020) Histological Review of Deminer-alized Dentin Matrix as a Carrier of rhBMP-2. Tissue Engineering, 26, 284-293. [Google Scholar] [CrossRef] [PubMed]
[6] Kim, Y.-K. (2012) Bone Graft Material Using Teeth. Journal of the Korean Association of Oral and Maxillofacial Surgeons, 38, 134-138. [Google Scholar] [CrossRef
[7] Janjua, O.S., Qureshi, S.M., Shaikh, M.S., et al. (2022) Au-togenous Tooth Bone Grafts for Repair and Regeneration of Maxillofacial Defects: A Narrative Review. International Journal of Environmental Research and Public Health, 19, 3690. [Google Scholar] [CrossRef] [PubMed]
[8] 肖闻澜, 胡琛, 荣圣安. 牙本质在骨组织工程学中的应用[J]. 口腔疾病防治, 2020, 28(2): 127-130.
[9] Ravindran, G. (2015) Dentin Matrix Proteins in Bone Tissue Engineering. Advances in Experimental Medicine and Biology, 881, 129-142. [Google Scholar] [CrossRef] [PubMed]
[10] Mohammed, G., Grawish, L.M. and Grawish, H.M. (2022) Demineralized Dentin Matrix for Dental and Alveolar Bone Tissues Regeneration: An Innovative Scope Review. Tissue Engineering and Regenerative Medicine, 19, 687-701. [Google Scholar] [CrossRef] [PubMed]
[11] Gulseren, G., Tansik, G. and Garifullin, R. (2018) Dentin Phos-phoprotein Mimetic Peptide Nanofibers Promote Biomineralization. Macromolecular Bioscience, 2018, Article ID: 1800080. [Google Scholar] [CrossRef] [PubMed]
[12] Pajor, K., Pajchel, L. and Kolmas, J. (2019) Hydroxyapatite and Fluorapatite in Conservative Dentistry and Oral Implantology—A Review. Materials (Basel), 12, Article No. 2683. [Google Scholar] [CrossRef] [PubMed]
[13] Kim, Y.K., Kim, S.G., Yun, P.Y., et al. (2014) Autogenous Teeth Used for Bone Grafting: A Comparison with Traditional Grafting Materials. Oral Surgery, Oral Medicine, Oral Pathology Oral Radiology, 117, 39-45. [Google Scholar] [CrossRef] [PubMed]
[14] Kim, G.W., Yeo, I.S., Kim, S.G., et al. (2011) Analysis of Crystal Line Structur of Autogenous Tooth Bone Graft Material: X-Ray Diffraction Analysis. Journal of the Korean Association of Oral and Maxillofacial Surgeons, 37, 225-228. [Google Scholar] [CrossRef
[15] Huang, Y.C., Lew, W.Z., Feng, S.W., et al. (2016) Histomor-phometric and Transcriptome Evaluation of Early Healing Bone Treated with a Novel Human Particulate Dentin Powder. Biomedical Materials, 12, 1-13. [Google Scholar] [CrossRef
[16] Moharamzadeh, K. (2008) Processed Bovine Dentine as a Bone Substitute. British Journal of Oral and Maxillofacial Surgery, 46, 110-113. [Google Scholar] [CrossRef] [PubMed]
[17] 王方. 冷冻干燥牙本质在牙髓-牙本质复合体再生中的应用基础研究[D]: [博士学位论文]. 西安: 第四军医大学, 2014: 1-100.
[18] Liu, Y., He, X.N. and Javed, R. (2021) Manufacture and Preliminary Evaluation of Acellular Tooth Roots as Allografts for Alveolar Ridge Augmentation. Jour-nal of Biomedical Materials Research A, 110, 122-130. [Google Scholar] [CrossRef] [PubMed]
[19] 刘宗霖, 郭克, 王文超, 等. 脱细胞脱钙人牙用于大鼠颅盖骨缺损修复的实验研究[J]. 中国口腔颌面外科杂志, 2018, 16(5): 397-401.
[20] Bono, N., Tarsini, P. and Candiani, G. (2019) BMP-2 and Type I Collagen Preservation in Human Deciduous Teeth after Demineralization. Journal of Applied Bio-materials & Functional Materials, 17, 1-8. [Google Scholar] [CrossRef] [PubMed]
[21] Tabatabaei, F.S., Tatari, S., Samadi, R., et al. (2016) Different Methods of 10 Dentin Processing for Application in Bone Tissue Engineering: A Systematic Review. Journal of Bio-medical Materials Research Part A, 104, 2616-2627. [Google Scholar] [CrossRef] [PubMed]
[22] Koga, T., Minamizato, T. and Kawai, Y. (2016) Bone Regeneration Using Dentin Matrix Depends on the Degree of Demineralization and Particle Size. PLOS ONE, 11, e014723. [Google Scholar] [CrossRef] [PubMed]
[23] Um, I.W., Kim, Y.K., Park, J.C., et al. (2019) Clinical Applica-tion of Autogenous Demineralized Dentin Matrix Loaded with Recombinant Human Bone Morphogenetic-2 for Socket Preservation: A Case Series. Clinical Implant Dentistry and Related Research, 21, 4-10. [Google Scholar] [CrossRef] [PubMed]
[24] Korsch, M. and Peichl, M. (2021) Retrospective Study: Lateral Ridge Aug-mentation Using Autogenous Dentin: Tooth-Shell Technique vs. Bone-Shell Technique. Public Health, 18, Article No. 3174. [Google Scholar] [CrossRef] [PubMed]
[25] 张丽娟, 王晓飞. 自体牙骨粉的研究与应用进展[J]. 口腔材料器械志, 2021, 30(3): 175-178.
[26] Schwarz, F., Schmucker, A. and Becke, J. (2016) Initial Case Report of an Extracted Tooth Root Used for Lateral Alveolar Ridge Augmentation. Journal of Clinical Periodontology, 43, 985-989. [Google Scholar] [CrossRef] [PubMed]
[27] Schwarz, F., Obreja, K. and Mayer, S. (2022) Efficacy of Autogenous Tooth Roots for a Combined Vertical and Horizontal Alveolar Ridge Augmentation and Staged Implant Placement. A Prospective Controlled Clinical Study. Journal of Clinical Periodontology, 49, 496-505. [Google Scholar] [CrossRef] [PubMed]
[28] Um, I.-W., Kim, Y.-K. and Mitsugi, M. (2017) Demineralized Dentin Ma-trix Scaffolds for Alveolar Bone Engineering. Indian Prosthodontic Society, 17, 120-127. [Google Scholar] [CrossRef] [PubMed]
[29] Togari, K., Miyazawa, K., Yagihashi, K., Tabuchi, M., Maeda, H., Kawai, T., et al. (2011) Bone Regeneration by Demineralized Dentin Matrix in Skull Defects of Rats. Journal of Hard Tissue Biology, 21, 25-34. [Google Scholar] [CrossRef
[30] Murata, M., Akazawa, T., Takahata, M., Ito, M., Tazaki, J., Hino, J., et al. (2010) Bone Induction of Human Tooth and Bone Crushed by Newly Developed Automatic Mill. Journal of the Ceram-ic Society of Japan, 118, 434-437. [Google Scholar] [CrossRef
[31] Kabir, A, Murata, M., Akazawa, T., et al. (2017) Evaluation of Perfo-rated Demineralized Dentin Scaffold on Bone Regeneration in Critical-Size Sheep Iliac Defects. Clinical Oral Implants Research, 28, e227-e235. [Google Scholar] [CrossRef] [PubMed]
[32] Lei, G., Wang, Y.Q., Yu, Y., et al. (2020) Dentin-Derived Inorganic Miner-als Promote the Osteogenesis of Bone Marrow-Derived Mesenchymal Stem Cells: Potential Applications for Bone Re-generation. Stem Cells International, 2020, Article ID: 8889731. [Google Scholar] [CrossRef] [PubMed]
[33] Kim, K.-W. (2014) Bone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles. Maxillofacial Plastic and Re-constructive Surgery, 36, 50-56. [Google Scholar] [CrossRef] [PubMed]
[34] Rijal, G. (2017) Human Tooth-Derived Biomaterial as a Graft Substitute for Hard Tissue Regeneration. Regenerative Medicine, 12, 263-273. [Google Scholar] [CrossRef] [PubMed]
[35] Kim, M.-G. (2021) The Effect of Autogenous Tooth Bone Graft Mate-rial without Organic Matter and Type I Collagen Treatment on Bone Regeneration. Maxillofacial Plastic and Reconstruc-tive Surgery, 43, 3-7. [Google Scholar] [CrossRef] [PubMed]
[36] Al-Asfour, A. (2017) Demineralized Xenogenic Dentin and Au-togenous Bone as Onlay Grafts to Rabbit Tibia. Implant Dentistry, 26, 232-237. [Google Scholar] [CrossRef
[37] 崔婷婷, 邱泽文, 邵阳, 仲维剑. 异种牙本质颗粒复合骨髓浓缩物在上颌窦提升中的成骨效应[J]. 中国组织工程研究, 2018, 22(30): 4806-4811.
[38] Elfana, A. (2021) Al-veolar Ridge Preservation Using Autogenous Whole-Tooth versus Demineralized Dentin Grafts: A Randomized Con-trolled Clinical Trial. Clinical Oral Implants Research, 32, 539-548. [Google Scholar] [CrossRef] [PubMed]
[39] Um, I.-W., Kim, Y.-K. and Park, J.-C. (2018) Clinical Application of Au-togenous Demineralized Dentin Matrix Loaded with Recombinant Human Bone Morphogenetic-2 for Socket Preserva-tion: A Case Series. Clinical Implant Dentistry and Related Research, 21, 4-10. [Google Scholar] [CrossRef] [PubMed]
[40] Jigar, M. (2021) Does an Autogenous Demineralized Dentin (ADDM) Graft Has the Ability to Form a New Bone. National Journal of Maxillofacial Surgery, 12, 181-187. [Google Scholar] [CrossRef
[41] Kim, Y.-K. (2010) Development of a Novel Bone Grafting Mate-rial Using Autogenous Teeth. Oral and Maxillofacial Surgery, 109, 496-503. [Google Scholar] [CrossRef] [PubMed]
[42] Kim, Y.-K., Lee, J.-H. and Um, I.-W. (2015) Guided Bone Re-generation Using Demineralized Dentin Matrix: Long-Term Follow-Up. Journal of Oral and Maxillofacial Surgery, 74, 515.e1-9. [Google Scholar] [CrossRef] [PubMed]
[43] Minamizato, T. (2017) Clinical Application of Autogenous Par-tially Demineralized Dentin Matrix Prepared Immediately after Extraction for Alveolar Bone Regeneration in Implant Dentistry: A Pilot Study. Journal of Oral and Maxillofacial Surgery, 47, 125-132.
[44] Pang, K.M. (2016) Autogenous Demineralized Dentin Matrix from Extracted Tooth for the Augmentation of Alveolar Bone Defect: A Prospective Ran-domized Clinical Trial in Comparison with Anorganic Bovine Bone. Clinical Oral Implants Research, 28, 809-815. [Google Scholar] [CrossRef] [PubMed]
[45] Korsch, M., Peichl, M. and Bartols, A. (2022) Lateral Alveolar Ridge Aug-mentation with Autologous Dentin of Periodontally Compromised Teeth: A Retrospective Study. International Journal of Environmental Research and Public Health, 19, Article No. 4560. [Google Scholar] [CrossRef] [PubMed]
[46] Gual-Vaqués, P. (2018) Autogenous Teeth Used for Bone Grafting: A Systematic Review. Medicina Oral, Patología Oral y Cirugía Bucal, 23, 112-119.
[47] 刘帅, 赵瑞, 汪俊妍. 自体牙骨粉移植改善正畸治疗中牙槽骨骨量不足的临床效果[J]. 中国医科大学学报, 2019, 48(2): 105-109.
[48] 孙娟斌, 刘海光, 柏宁. 自体牙本质颗粒与Bio-Oss骨粉植入治疗牙周骨缺损的临床观察[J]. 口腔医学, 2016, 36(12): 1127-1131.
[49] Upadhyay, P., Blaggana, V., Tripathi, P. and Jindal, M. (2019) Treatment of Furcation Involvement Using Autogenous Tooth Graft with 1-Year Follow-Up: A Case Series. Clinical Advances in Periodontics, 9, 4-8. [Google Scholar] [CrossRef] [PubMed]
[50] 刘一秀, 瞿杨, 李真华, 王洪鹏. 开窗减压术联合二期刮治术及自体牙骨粉植入在治疗颌骨较大囊肿中的应用[J]. 华西口腔医学杂志, 2020, 38(4): 464-469.