巩膜交联法防治近视的基础研究进展
The Progress of Scleral Cross-Linking in the Prevention and Treatment of Myopia
DOI: 10.12677/HJO.2022.114042, PDF,    科研立项经费支持
作者: 艾瑶瑶#：延安大学医学院，陕西 延安 ；成 静：西安市第九医院眼科，陕西 西安；杜军辉*：延安大学医学院，陕西 延安；西安市第九医院眼科，陕西 西安
关键词: 病理性近视；巩膜交联法；综述；Pathological Myopia； Scleral Cross-Linking； Review
摘要: 高度近视是常见的致盲性眼病，国内因高度近视致盲者已达30多万人。病理性近视常伴有视网膜脱离、近视性黄斑病变、后巩膜葡萄肿等并发症，最后引起严重的低视力和视力丧失。研究表明，这些并发症的出现与巩膜的生物力学性能降低有关，巩膜胶原交联法可以增强巩膜的生物力学性能，使得巩膜抗变形能力增加，阻止或延缓巩膜扩张，从而缓解和控制近视的发展。
Abstract: High myopia is a common blinding eye disease, and the number of people blinded by high myopia in China has reached 300000. Pathological myopia is often associated with Amotio retinae, Myopic maculopathy and Posterior scleral staphyloma complications, the result is severe low vision and loss of vision. Researches show that the occurrence of these complications is related to the decrease of scleral biomechanical properties, Scleral collagen cross-linking can enhance scleral biomechanical properties, making the sclera more resistant to deformation, prevent or delay scleral expansion, so as to alleviate and control the development of myopia.
文章引用：艾瑶瑶, 成静, 杜军辉. 巩膜交联法防治近视的基础研究进展[J]. 眼科学, 2022, 11(4): 310-316. https://doi.org/10.12677/HJO.2022.114042

参考文献

[1] Holden, B.A., Fricke, T.R., Wilson, D.A., et al. (2016) Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. Ophthalmology, 123, 1036-1042.
[Google Scholar] [CrossRef] [PubMed]
[2] Wong, Y.L. and Saw, S.M. (2016) Epidemiology of Pathologic Myopia in Asia and Worldwide. The Asia-Pacific Journal of Ophthalmology (Phila), 5, 394-402.
[Google Scholar] [CrossRef] 
[3] Huang, J., Wen, D., Wang, Q., et al. (2016) Efficacy Comparison of 16 Interventions for Myopia Control in Children: A Network Meta-Analysis. Ophthalmology, 123, 697-708.
[Google Scholar] [CrossRef] [PubMed]
[4] He, M., Huang, W., Zheng, Y., et al. (2007) Refractive Error and Visual Impairment in School Children in Rural Southern China. Ophthalmology, 114, 374-382.
[Google Scholar] [CrossRef] [PubMed]
[5] Zhao, J., Pan, X., Sui, R., et al. (2000) Refractive Error Study in Children: Results from Shunyi District, China. American Journal of Ophthalmology, 129, 427-435.
[Google Scholar] [CrossRef] 
[6] Pan, C.W., Ramamurthy, D. and Saw, S.M. (2012) Worldwide Prevalence and Risk Factors for Myopia. Ophthalmic and Physiological Optics, 32, 3-16.
[Google Scholar] [CrossRef] [PubMed]
[7] Cheng, S.C., Lam, C.S. and Yap, M.K. (2013) Prevalence of Myopia-Related Retinal Changes among 12-18 Year Old Hong Kong Chinese High Myopes. Ophthalmic and Physiological Optics, 33, 652-660.
[Google Scholar] [CrossRef] [PubMed]
[8] Rada, J.A., Shelton, S. and Norton, T.T. (2006) The Sclera and Myopia. Experimental Eye Research, 82, 185-200.
[Google Scholar] [CrossRef] [PubMed]
[9] 王莹, 韩泉洪, 韩风梅, 等. 甘油醛后巩膜交联治疗豚鼠形觉剥夺性近视眼的研究[J]. 中华眼科杂志, 2014, 50(1): 51-59.
[10] 容烁. 离子导入核黄素-紫外线A快速巩膜交联术治疗近视的实验研究[D]: [博士学位论文]. 太原: 太原理工大学, 2017.
[11] Edwards, A.M. (2014) Structure and General Properties of Flavins. Methods in Molecular Biology, 1146, 3-13.
[Google Scholar] [CrossRef] [PubMed]
[12] Iseli, H.P., Popp, M., Seiler, T., et al. (2011) Laboratory Measurement of the Absorption Coefficient of Riboflavin for Ultraviolet Light (365 nm). Journal of Refractive Surgery, 27, 195-201.
[Google Scholar] [CrossRef] 
[13] 李娜, 杨建云, 肖炳坤, 等. 核黄素临床应用研究进展[J]. 解放军医药杂志, 2012, 24(4): 52-54.
[14] 罗贤懋, 林培中, 刘雨菁, 等. 核黄素预防恶性肿瘤的研究进展[J]. 癌症进展, 2020, 18(4): 325-330.
[15] 邹迎, 张丰菊. 巩膜胶原交联法在病理性近视中的研究新进展[J]. 中国实用眼科杂志, 2016, 34(9): 913-916.
[16] 贺美男. 核黄素-紫外线A巩膜交联对实验性近视的影响研究[D]: [硕士学位论文]. 天津: 天津医科大学, 2017.
[17] 吴苗琴, 刘辉, 张岚, 等. 口服核黄素诱导巩膜交联防治豚鼠近视的初步研究[C]//2014浙江省眼科学术年会论文汇编. 2014: 261.
[18] Sun, M., Zhang, F., Li, Y., et al. (2020) Evaluation of the Safety and Long-Term Scleral Biomechanical Stability of UVA Cross-Linking on Scleral Collagen in Rhesus Monkeys. Journal of Refractive Surgery, 36, 696-702.
[Google Scholar] [CrossRef] 
[19] Gawargious, B.A., Le, A., Lesgart, M., et al. (2020) Differential Regional Stiffening of Sclera by Collagen Cross-Linking. Current Eye Research, 45, 718-725.
[Google Scholar] [CrossRef] [PubMed]
[20] 陶祥臣. 核黄素/蓝光(440 nm)紫外线兔巩膜胶原交联的生物力学研究[D]: [博士学位论文]. 济南: 山东大学, 2015.
[21] 邹迎, 张淼, 张丰菊. 不同浓度核黄素-蓝光交联对兔眼巩膜组织生物力学的影响[J]. 中华眼视光学与视觉科学杂志, 2017, 19(1): 9-13.
[22] Li, Y., Liu, C., Sun, M., et al. (2019) Ocular Safety Evaluation of Blue Light Scleral Cross-Linking in Vivo in Rhesus Macaques. Graefe’s Archive for Clinical and Experimental Ophthalmology, 257, 1435-1442.
[Google Scholar] [CrossRef] [PubMed]
[23] 许寅聪, 陈静, 赵亚芳, 等. 京尼平和甲醛缓释体类防腐剂对活体兔巩膜交联的有效性研究[J]. 河北医药, 2020, 42(4): 494-498.
[24] 吴元, 次仁琼达, 汤韵, 等. 天然生物交联剂京尼平对猪巩膜交联效果的初步研究[J]. 中国斜视与小儿眼科杂志, 2019, 27(3): 24-26.
[25] 吴元, 杨松霖, 李海丽, 等. 不同交联方法对离体猪巩膜交联效果的比较[J]. 中华实验眼科杂志, 2013, 31(2): 168-171.
[26] Mehta, J., Takaoka, A., Zyablitskaya, M., et al. (2020) Development of a Topical Tissue Cross-Linking Solution Using Sodium Hydroxymethylglycinate (SMG): Viscosity Effect. Bioscience Reports, 40, BSR20191941.
[Google Scholar] [CrossRef] 
[27] Kwok, S., Forward, S., Wertheimer, C.M., et al. (2019) Selective Equatorial Sclera Crosslinking in the Orbit Using a Metal-Coated Polymer Waveguide. Investigative Ophthalmology & Visual Science, 60, 2563-2570.
[Google Scholar] [CrossRef] [PubMed]

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