高龄合并2型糖尿病结直肠癌患者预后预测指标分析

Analysis on Prognostic Predictors of Elderly Colorectal Cancer Patients Combined with Type 2 Diabetes Mellitus

摘要: 结直肠癌是最常见的恶性肿瘤之一，近年来，随着生活水平的提升，高龄患者逐步增多，我国人口调查显示老年人群预计将占据世界人口的22%的比例，因此未来将有更多的高龄结直肠癌患者，而高龄患者常患有一些基础疾病，如心血管相关疾病、肺部疾病，以及近年老年糖尿病患者比例的增加，使得共患2型糖尿病的高龄结直肠癌患者在未来社会中占很大的比重。此外，有研究证实糖尿病与结直肠癌的发展密切相关，特别是在老年人中。而手术依然是治疗结直肠癌的主要手段。此类患者能否行手术治疗？手术是否安全？因此我们有必要对高龄且合并2型糖尿病患者的研究现状进行整理，找到可以代表高龄和2型糖尿病相关的预测指标，建立预测模型，一方面可以评估能否手术，另一方面，可以根据预测结果提前采取干预手段以减少术后不良结局。这篇综述中，讨论了与高龄和2型糖尿病的相关指标及未来展望。

Abstract: Colorectal cancer is one of the most common malignant tumours. In recent years, with the im-provement of living standards, the number of elderly patients has gradually increased, and China’s population survey shows that the elderly population is expected to occupy 22% of the world’s population, so there will be more elderly colorectal cancer patients in the future, and elderly pa-tients often suffer from some underlying diseases, such as cardiovascular-related diseases and lung diseases, as well as the proportion of elderly diabetics in recent years. The increase in the proportion of older patients with diabetes mellitus in recent years has led to a large proportion of older colorectal cancer patients with type 2 diabetes mellitus in society in the future. In addition, studies have confirmed a strong association between diabetes and the development of colorectal cancer, particularly in the elderly. Surgery remains the mainstay of treatment for colorectal cancer. Can these patients be treated surgically? Is surgery safe? It is therefore necessary to collate the current state of research on the elderly with type 2 diabetes, to find predictors that represent the association between elderly patients and type 2 diabetes, and to develop predictive models that can, on the one hand, assess the possibility of surgery and, on the other hand, allow for early interventions to reduce adverse postoperative outcomes based on the predictive results. In this review, indicators associated with elderly patients and type 2 diabetes are discussed and future perspectives are provided.