系统性红斑狼疮中外泌体及其作用的研究进展
Advances in Studies on Exosomes and Their Roles in Systemic Lupus Erythematosus
DOI: 10.12677/ACM.2022.12121725, PDF,   
作者: 吕 攀, 刘平丹, 周晓琴, 朱茂灵, 刘剑平*：川北医学院附属医院，四川 南充
关键词: 系统性红斑狼疮；外泌体；Systemic Lupus Erythematosus (SLE)； Exosome
摘要: 外泌体(exosomes)是携带多种蛋白质、脂质和遗传物质的细胞外囊泡，参与局部和系统间信息的交换，在多种自身免疫性疾病中发挥重要的免疫调节作用。外泌体具有稳定性、低免疫原性、生物相容性和克服生物屏障等固有特性，使其可以成为药物载体，特别是用于基因治疗。本文将综述外泌体在SLE中的作用，有助于为研究SLE的病因机制和SLE治疗的靶向提供新的方向。
Abstract: Exosomes are extracellular vesicles that carry a variety of proteins, genetic material and lipids, they are involved in the exchange of local and intersystemic information, and play an important immunomodulatory role in a variety of autoimmune diseases. Exosomes have inherent properties such as stability, low immunogenicity, biocompatibility, and overcoming biological barriers, and has potential for drug vectors, especially for gene therapy. This paper will review the role of exosomes in SLE, which will help to provide a new direction for the study of the etiological mechanism of SLE and the targeting of SLE therapy.
文章引用：吕攀, 刘平丹, 周晓琴, 朱茂灵, 刘剑平. 系统性红斑狼疮中外泌体及其作用的研究进展[J]. 临床医学进展, 2022, 12(12): 11975-11979. https://doi.org/10.12677/ACM.2022.12121725

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