光动力疗法治疗浅表性食管癌的研究进展
The Research Progress of Photodynamic Therapy for Superficial Esophageal Carcinoma
DOI: 10.12677/ACM.2022.12121747, PDF,   
作者: 吴 晨:济宁医学院临床医学院,山东 济宁;王凌云*:济宁市第一人民医院消化内科,山东 济宁
关键词: 食管癌光动力疗法内镜黏膜下剥离术内镜黏膜下切除术Esophageal Carcinoma Photodynamic Therapy Endoscopic Submucosal Dissection Endoscopic Mucosal Resection
摘要: 浅表性食管癌,指的是局限于黏膜层和黏膜下层,不论有无淋巴结转移。目前,临床上很多浅表性食管癌病人常常伴随其他疾病无法行内镜及外科手术治疗,在这种情况下,光动力疗法作为一种对肿瘤细胞选择性高、可重复的微创治疗受到越来越多的关注。如今关于光动力治疗食管癌的文献较多,然而,针对其对于浅表性食管癌的总结甚少,本文对比了光动力疗法与其他技术对浅表性食管癌的治疗疗效,并分析其研究进展,希望为光动力治疗浅表性食管癌的临床开展提供参考。
Abstract: Regardless of lymph node metastases, superficial esophageal carcinoma is defined as being local-ized to the mucosa and submucosa. Many individuals who have superficial esophageal carcinoma and additional clinical conditions are now ineligible for endoscopic or surgical treatment. Photo-dynamic therapy (PDT) is gaining popularity in this case as a highly reproducible and minimally invasive technique that is highly selective for tumor cells. There is a lot of literature on photody-namic therapy for esophageal carcinoma nowadays, but very little focused on superficial esophageal carcinoma. With the intention of serving as a reference for the clinical development of pho-todynamic therapy in patients with superficial esophageal cancer, this paper compares the thera-peutic effects of photodynamic therapy with those of other technologies for superficial esophageal cancer and analyzes its research progress.
文章引用:吴晨, 王凌云. 光动力疗法治疗浅表性食管癌的研究进展[J]. 临床医学进展, 2022, 12(12): 12123-12129. https://doi.org/10.12677/ACM.2022.12121747

参考文献

[1] Malik, S., Sharma, G., Sanaka, M.R. and Thota, P.N. (2018) Role of Endoscopic Therapy in Early Esophageal Cancer. World Journal of Gastroenterology, 24, 3965-3973. [Google Scholar] [CrossRef] [PubMed]
[2] Yano, T. and Wang, K.K. (2020) Photodynamic Therapy for Gastrointestinal Cancer. Photochemistry and Photobiology, 96, 517-523. [Google Scholar] [CrossRef] [PubMed]
[3] Allison, R.R. (2014) Photodynamic Therapy: Oncologic Horizons. Future Oncology, 10, 123-124. [Google Scholar] [CrossRef] [PubMed]
[4] Mossakowska, B., Fabisiewicz, A. and Siedlecki, J. (2021) [Photodynamic Therapy—Significance in Oncology]. Postępy Biochemii, 67, 236-247. [Google Scholar] [CrossRef] [PubMed]
[5] Didamson, O.C. and Abrahamse, H. (2021) Targeted Photodynamic Diagnosis and Therapy for Esophageal Cancer: Potential Role of Functionalized Nanomedicine. Pharmaceutics, 13, Article 1943. [Google Scholar] [CrossRef] [PubMed]
[6] Dobson, J., de Queiroz, G.F. and Golding, J.P. (2018) Pho-todynamic Therapy and Diagnosis: Principles and Comparative Aspects. Veterinary Journal, 233, 8-18. [Google Scholar] [CrossRef] [PubMed]
[7] 薛欢, 王佩茹, 王秀丽. 光动力疗法治疗肿瘤的免疫机制研究进展[J]. 国际免疫学杂志, 2020, 43(1): 51-55.
[8] Pech, O., May, A., Manner, H., Behrens, A., et al. (2014) Long-Term Efficacy and Safety of Endoscopic Resection for Patients with Mucosal Adenocarcinoma of The Esophagus. Gastroenterology, 146, 652-660.e1. [Google Scholar] [CrossRef] [PubMed]
[9] Ishihara, R., Tanaka, H., Iishi, H., Takeuchi, Y., et al. (2008) Long-Term Outcome of Esophageal Mucosal Squamous Cell Carcinoma without Lymphovascular Involvement after Endoscopic Resection. Cancer, 112, 2166-2172. [Google Scholar] [CrossRef] [PubMed]
[10] Haidry, R.J., Butt, M.A., Dunn, J., Banks, M., et al. (2013) Radiofre-quency Ablation for Early Oesophageal Squamous Neoplasia: Outcomes form United Kingdom Registry. World Journal of Gastroenterology, 19, 6011-6019. [Google Scholar] [CrossRef] [PubMed]
[11] Yachimski, P., Puricelli, W.P. and Nishioka, N.S. (2008) Patient Predictors of Esophageal Stricture Development after Photodynamic Therapy. Clinical Gastroenterology and Hepatology, 6, 302-308. [Google Scholar] [CrossRef] [PubMed]
[12] Keeley, S.B., Pennathur, A., Gooding, W., Landreneau, R.J., et al. (2007) Photodynamic Therapy with Curative Intent for Barrett’s Esophagus with High Grade Dysplasia and Superficial Esophageal Cancer. Annals of Surgical Oncology, 14, 2406-2410. [Google Scholar] [CrossRef] [PubMed]
[13] Pech, O., Gossner, L., May, A., Rabenstein, T., et al. (2005) Long-Term Results of Photodynamic Therapy with 5-Aminolevulinic Acid for Superficial Barrett’s Cancer and High-Grade Intraepithelial Neoplasia. Gastrointestinal Endoscopy, 62, 24-30. [Google Scholar] [CrossRef
[14] Pimentel-Nunes, P., Dinis-Ribeiro, M., Ponchon, T., Repici, A., et al. (2015) Endoscopic Submucosal Dissection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy, 47, 829-854. [Google Scholar] [CrossRef] [PubMed]
[15] Poos, H., Sorleto, M., Fetzner, U.K., Begum, N., et al. (2022) En-doscopic Interventional Treatment of Precancerous Lesions and Early Carcinoma of the Esophagus—Criteria and Techniques of Local Ablation and Resection. Therapeutische Umschau, 79, 167-170. [Google Scholar] [CrossRef] [PubMed]
[16] Aadam, A.A. and Abe, S. (2018) Endoscopic Submucosal Dis-section for Superficial Esophageal Cancer. Diseases of the Esophagus, 31, doy021. [Google Scholar] [CrossRef] [PubMed]
[17] Yang, D., Coman, R.M., Kahaleh, M., Waxman, I., et al. (2017) Endo-scopic Submucosal Dissection for Barrett’s Early Neoplasia: A Multicenter Study in the United States. Gastrointestinal Endoscopy, 86, 600-607. [Google Scholar] [CrossRef] [PubMed]
[18] Chai, N.L., Feng, J., Li, L.S., Liu, S.Z., et al. (2018) Effect of Polyglycolic Acid Sheet plus Esophageal Stent Placement in Preventing Esophageal Stricture after Endoscopic Submucosal Dissection in Patients with Early-Stage Esophageal Cancer: A Randomized, Controlled Trial. World Journal of Gastroenterology, 24, 1046-1055. [Google Scholar] [CrossRef] [PubMed]
[19] Ono, S., Fujishiro, M., Niimi, K., Goto, O., et al. (2009) Long-Term Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Cell Neoplasms. Gastrointestinal Endoscopy, 70, 860-866. [Google Scholar] [CrossRef] [PubMed]
[20] 毛艳会, 文黎明, 李林艳, 等. 内镜黏膜下剥离术治疗大面积食管早期癌的随访分析[J]. 中国内镜杂志, 2020, 26(2): 43-7.
[21] 刘宁, 刘丹, 刘冰熔, 等. 早期食管癌及癌前病变内镜黏膜下剥离术后食管狭窄预测模型的构建及测试[J]. 中华消化内镜杂志, 2021, 38(9): 728-732.
[22] 马佳怡, 王永霞, 薛微, 等. 光动力治疗在食管肿瘤中的疗效及安全性分析[J]. 中华消化内镜杂志, 2017, 34(12): 900-902.
[23] Hua, X., Li, Y., Ma, H., Zhang, W., et al. (2017) Photodynamic Therapy versus Endoscopic Submucosal Dissection for Management of Patients with Early Esophageal Neoplasia: A Retrospective Study. Journal of Thoracic Disease, 9, 5046-5051. [Google Scholar] [CrossRef] [PubMed]
[24] Wolfsen, H.C., Woodward, T.A. and Raimondo, M. (2002) Photodynamic Therapy for Dysplastic Barrett Esophagus and Early Esophageal Adenocarcinoma. Mayo Clinic Proceedings, 77, 1176-1181. [Google Scholar] [CrossRef] [PubMed]
[25] Tanaka, T., Matono, S., Nagano, T., Murata, K., et al. (2011) Photodynamic Therapy for Large Superficial Squamous Cell Carcinoma of the Esophagus. Gastrointestinal Endoscopy, 73, 1-6. [Google Scholar] [CrossRef] [PubMed]
[26] Shishkova, N., Kuznetsova, O. and Berezov, T. (2013) Photodynamic Therapy in Gastroenterology. Journal of Gastrointestinal Cancer, 44, 251-259. [Google Scholar] [CrossRef] [PubMed]
[27] Radu, A., Grosjean, P., Jaquet, Y., Pilloud, R., et al. (2005) Photodynamic Therapy and Endoscopic Mucosal Resection as Minimally Invasive Approaches for the Treatment of Early Esophageal Tumors: Pre-Clinical and Clinical Experience in Lausanne. Photodiagnosis and Photodynamic Therapy, 2, 35-44. [Google Scholar] [CrossRef
[28] Correia, J.H., Rodrigues, J.A., Pimenta, S., Dong, T., et al. (2021) Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions. Pharmaceutics, 13, Article 1332. [Google Scholar] [CrossRef] [PubMed]
[29] Kawazoe, K., Isomoto, H., Yamaguchi, N., Inoue, N., et al. (2010) Effects of Photodynamic Therapy for Superficial Esophageal Squamous Cell Carcinoma in Vivo and in Vitro. Oncology Letters, 1, 877-882. [Google Scholar] [CrossRef] [PubMed]
[30] Matzi, V., Maier, A., Sankin, O., Lindenmann, J., et al. (2004) 5-Aminolaevulinic Acid Compared to Polyhematoporphyrin Photosensitization for Photodynamic Therapy of Malignant Bronchial and Esophageal Stenosis: Clinical Experience. Photodiagnosis and Photodynamic Therapy, 1, 137-143. [Google Scholar] [CrossRef
[31] 华胸怀, 张玮, 张瑞祥, 等. 内镜下光动力治疗食管鳞癌及癌前病变的临床价值[J]. 中华消化内镜杂志, 2017, 34(1): 38-42.
[32] Rashid, M.U., Alomari, M., Afraz, S. and Erim, T. (2022) EMR and ESD: Indications, Techniques and Results. Surgical Oncology, 43, Article ID: 101742. [Google Scholar] [CrossRef] [PubMed]
[33] 高社干, 董彩红, 单探幽. 食管癌光动力治疗临床应用专家共识[J]. 食管疾病, 2020, 2(1): 1-7.
[34] Simões, J.C.S., Sarpaki, S., Papadimitroulas, P., Therrien, B., et al. (2020) Conjugated Photosensitizers for Imaging and PDT in Cancer Research. Journal of Medicinal Chemistry, 63, 14119-14150. [Google Scholar] [CrossRef] [PubMed]
[35] Abrahamse, H. and Hamblin, M.R. (2016) New Photosensi-tizers for Photodynamic Therapy. The Biochemical Journal, 473, 347-364. [Google Scholar] [CrossRef
[36] Kwiatkowski, S., Knap, B., Przystupski, D., Saczko, J., et al. (2018) Photodynamic Therapy—Mechanisms, Photosensitizers and Combinations. Biomedicine & Pharmacotherapy, 106, 1098-1107. [Google Scholar] [CrossRef] [PubMed]
[37] Duse, L., Agel, M.R., Pinnapireddy, S.R., Schäfer, J., et al. (2019) Photodynamic Therapy of Ovarian Carcinoma Cells with Curcumin-Loaded Biodegradable Polymeric Nano-particles. Pharmaceutics, 11, Article 282. [Google Scholar] [CrossRef] [PubMed]
[38] Chizenga, E.P. and Abrahamse, H. (2020) Nanotechnology in Modern Photodynamic Therapy of Cancer: A Review of Cellular Resistance Patterns Affecting the Therapeutic Response. Pharmaceutics, 12, Article 632. [Google Scholar] [CrossRef] [PubMed]
[39] Li, T. and Yan, L. (2018) Functional Polymer Nanocarriers for Photodynamic Therapy. Pharmaceuticals, 11, Article 133. [Google Scholar] [CrossRef] [PubMed]
[40] Montaseri, H., Kruger, C.A. and Abrahamse, H. (2021) Inorganic Nanoparticles Applied for Active Targeted Photodynamic Therapy of Breast Cancer. Pharmaceutics, 13, Article 296. [Google Scholar] [CrossRef] [PubMed]