LAG-3在微卫星不稳定性高频结肠癌中的诊断和治疗的研究进展
Research Progress of LAG-3 in the Diagnosis and Treatment of Microsatellite Instability High-Frequency Colon Cancer
DOI: 10.12677/ACM.2022.12121755, PDF,   
作者: 李 哲：大理大学临床医学院，云南 大理；谭云波, 金礼权：大理大学第一附属医院普外一科，云南 大理
关键词: LAG-3；微卫星不稳定性高频结肠癌；免疫检查点；免疫检查点抑制剂；LAG-3； Microsatellite Instability High Frequency Colon Cancer； Immune Checkpoint； Immunocheckpoint Inhibitor
摘要: 结肠癌是消化系统最常见的恶性肿瘤，起源于结肠黏膜上皮细胞，其受到了各种物理、生化因子及基因突变，失去了正常细胞的生长机制，发病率居消化道恶性肿瘤第3位，预后极差，5年生存率极低，大多数诊断已处于中晚期阶段。目前，结肠癌的治疗仍以手术为主，辅以新辅助化疗、化疗、放疗、靶向治疗、免疫治疗等综合治疗模式。LAG-3基因的过度表达可能是微卫星不稳定性高频(Microsatellite Instability High frequency, MSI-H)结肠癌发生机制之一。针对MSI-H结肠癌使用免疫检查点抑制剂可取得较好的靶向治疗效果。
Abstract: Colon cancer is the most common malignant tumor of the digestive system, which originates from the epithelial cells of colon mucosa. It has suffered various physical and biochemical factors and gene mutations, and lost the growth mechanism of normal cells. Its incidence rate ranks the third in malignant tumors of the digestive tract. Its prognosis is extremely poor, and its five-year survival rate is extremely low. Most of the diagnoses are in the middle and late stages. At present, the treatment of colon cancer is still dominated by surgery, supplemented by neoadjuvant chemother-apy, chemotherapy, radiotherapy, targeted therapy, immunotherapy and other comprehensive treatment modes. The overexpression of LAG-3 gene may be one of the mechanisms of Microsatellite instability high frequency (MSI-H) colon cancer. The use of immunocheckpoint inhibitors for MSI-H colon cancer can achieve better targeted therapeutic effect.
文章引用：李哲, 谭云波, 金礼权. LAG-3在微卫星不稳定性高频结肠癌中的诊断和治疗的研究进展[J]. 临床医学进展, 2022, 12(12): 12184-12190. https://doi.org/10.12677/ACM.2022.12121755

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