肌醇加氧酶在早期糖尿病肾病中的预测作用

The Predicted Role of MIOX Expression in the Early Diabetic Renal Damage

摘要: 目的：探讨肌醇加氧酶在早期糖尿病肾病中的意义。方法：60例糖尿病患者按照微量尿蛋白/肌酐、估计的肾小球滤过率分为糖尿病组、糖尿病蛋白尿组、糖尿病肾损害组，20例健康体检者作为健康对照组，进行体格检查和生化指标检测及肌醇加氧酶检测。结果：与健康对照组相比，糖尿病各3组的血糖、糖化血红蛋白、血肌酐、尿微量蛋白尿/肌酐、尿视黄醇结合蛋白、血尿肌醇加氧酶明显升高(均P < 0.05)，糖尿病各组间肾损害组血肌酐、血尿MIOX最高(均P < 0.05) (均P < 0.05)，尿ACR、URBP蛋白尿组和肾损害组之间无差异(均P > 0.05)，糖尿病和糖尿病蛋白尿组之间血尿MIOX无差异(均P > 0.05)，相关性分析显示，血、尿MIOX与血糖、血肌酐、UACR、URBP、病程、TG、SBp呈正相关，与eGFR呈负相关，与年龄、TC、HDL、LDL、DBp、ANG无关。结论：MIOX与糖尿病肾损害相关，且在糖尿病肾脏损害早期出现变化，MIOX有可能成为糖尿病早期肾病的标志物。

Abstract: Objective: To explore the clinical significance of MIOX expression in the early stage of diabetic renal damage. Methods: 60 patients who were diagnosis T2 DM were enrolled into the study. According to the UACR, eGFR, they were divided into three groups: diabetes mellitus (n = 20), diabetec nephrop-athy (n = 20), diabetic renal damage (n = 20). Normal control (n = 20) were from physical examina-tion in the hospital. All patient and normal control were detected biochemical index and the ex-pression of MIOX in serum and urine. Results: Compared to the control group, the levels of fast glu-cos, HbA1c, serum creatin, uACR, URBP, serum and urin MIOX were obviously incresed in 3 groups with diabetes (P < 0.05). Between the three groups with diabets, the level of serum cretin, serum and urin MIOX were higher in diabetic renal damage (P < 0.05). The levels of UACR and URBP were no obviously differencs between diabetec nephropathy and renal damage groups (P > 0.05). The levels of serum and urin MIOX were no obviously differencs between diabetes mellitus and diabetec nephropathy (P > 0.05). Correlation analysis showed that serum and urin MIOX were positively re-lated with fast glucos, serum cretin, UACR URBP, diabetes duration, TG, SBp and negatively related with eGFR. It was no relevant with age, TC HDL LDL DBp ANG. Conclusion: The levels of MIOX were related with diabetes renal damage and increased in the early stage of diabetes renal damage. The level of MIOX may serve as a new biomarker in the early stage of diabetes nephropathy.