凉山彝族地区儿童过敏性紫癜发生肾脏损害的危险因素分析

The Risk Factors Analysis of Renal Impairment in Children with Henoch-Schonlein Purpura in Liangshan Prefecture

摘要: 目的：讨论凉山彝族地区儿童过敏性紫癜发生肾脏损害的危险因素。方法：把1303例凉山彝族地区儿童过敏性紫癜的病历分为有肾损害的情况的一组(n = 380)以及没有肾损害的一组(n = 923)，使用X2来检验以及秩和检验，以有肾损害以及无肾损害的这一组分为应变量，而有着较为显著性差异的临床性指标和年龄内容为自变量，逐步进行logistic回归分析使得肾脏受损的危险性因素。结果：29%患儿出现了肾损害，单因素分析提示反复性皮疹、消化道出血以及腹痛相应内容在出现肾损害以及没有出现肾损害两类数据之中存在着较大的差异性(p < 0.05)，同时经过逐步的logistic回归分析表明了反复性的皮疹以及腹痛是出现过敏性紫癜肾脏损害的十分关键性影响因素(p < 0.05)。结论：较为反复出现的皮疹以及腹痛是导致过敏性紫癜肾损害的重要危险性因素，所以凉山彝族地区儿童过敏性紫癜发生肾脏损害时需要格外关注以及预防上述症状，加强相应的随访工作。

Abstract: Objective: To discuss the risk factors of renal damage in children with Henoch-Schonlein purpura in Liangshan Yi Autonomous Prefecture. Methods: The clinical data of Henoch-Schonlein purpura chil-dren in the First People’s Hospital of Liangshan Yi Autonomous Prefecture were collected. 1303 cases were divided into renal damage (n = 380) group and no renal damage group (n = 923). Lo-gistic regression analysis was performed to analyze the risk factors of renal damage. Results: 29% of children suffered from renal damage. Univariate analysis showed that there were significant sta-tistically differences in recurrent rash, gastrointestinal bleeding and abdominal pain between renal damage and no renal damage (p < 0.05). Finally, logistic regression analysis showed that recurrent rash and abdominal pain were critical risk factors for renal damage in children Henoch- Schonlein purpura (p < 0.05). Conclusion: Recurrent rash and abdominal pain are important risk factors for renal damage in Henoch-Schonlein purpura. Therefore, clinical doctors should pay more attention to these symptoms and strengthen the corresponding follow-up work.