靶向自噬在三阴性乳腺癌中的应用
Application of Targeted Autophagy in Triple Negative Breast Cancer
DOI: 10.12677/ACM.2023.131010, PDF,   
作者: 吕 敏：济宁医学院临床医学院，山东 济宁；山长平*：济宁医学院附属医院肿瘤科，山东 济宁
关键词: 自噬；三阴性乳腺癌；靶向治疗；抗肿瘤；耐药性；Autophagy； Triple Negative Breast Cancer； Targeted Therapy； Anti-Tumor； Drug Resistance
摘要: 自噬是一种降解功能失调蛋白质和细胞器的分解代谢过程，与癌症细胞在治疗、代谢应激、缺氧、饥饿和生长因子缺乏下的生存密切相关，在癌症进展的背景下，值得注意的是自噬被认为是一把“双刃剑”。三阴性乳腺癌(TNBC)是人类乳腺癌的一种亚型，是预后最差的亚型之一，TNBC的主要治疗方案包括手术、放疗、化疗和全身治疗。尽管最近在化疗方面取得了进展，但仍有40%的TNBC患者发生了转移性复发和复发。因此，探究TNBC的分子特征对于确定可选择的靶点以开发新的有效的治疗方法是必要的。近年来，自噬在TNBC进展中的关键作用逐渐显现。本篇自噬将关注中点关注自噬对TNBC关键靶点的作用以及探讨将自噬作为新的治疗模式的治疗方法。
Abstract: Autophagy is a catabolic process that degrades dysfunctional proteins and organelle, which is closely related to the survival of cancer cells under treatment, metabolic stress, hypoxia, starvation and growth factor deficiency. In the context of cancer progression, it is worth noting that autophagy is considered a “double-edged sword”. Triple negative breast cancer (TNBC) is a subtype of human breast cancer with one of the worst prognosis. The main treatment options for TNBC include sur-gery, radiotherapy, chemotherapy and systemic therapy. Despite recent advances in chemotherapy, 40% of TNBC patients develop metastatic relapses and relapses. Therefore, it is necessary to ex-plore the molecular characteristics of TNBC to identify alternative targets for the development of new and effective therapies. In recent years, autophagy has gradually emerged as a key role in the development of TNBC. In this paper, autophagy will focus on the midpoint, the role of autophagy on the key targets of TNBC, and explore the therapeutic method of using autophagy as a new therapeu-tic mode.
文章引用：吕敏, 山长平. 靶向自噬在三阴性乳腺癌中的应用[J]. 临床医学进展, 2023, 13(1): 62-67. https://doi.org/10.12677/ACM.2023.131010

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