脓毒症患者的微循环功能检测技术进展
Progress of Microcirculation Function Detection Technology in Patients with Sepsis
DOI: 10.12677/ACM.2023.131032, PDF,    科研立项经费支持
作者: 郭沛雨, 茅 敏, 郭 飞, 单 亮*：青岛大学附属医院重症医学科，山东 青岛；李 秀：青岛大学附属医院门诊部，山东 青岛；单岩笙, 刘 佳, 杨克鑫：青岛大学医学部，山东 青岛
关键词: 脓毒症；微循环；检测技术；Sepsis； Microcirculation； Detection Technology
摘要: 脓毒症是指由于感染引起的机体反应失调，进而导致的严重的器官功能障碍。微循环功能改变是脓毒症重要的病理生理机制之一，也是影响脓毒症患者预后的重要因素，对于脓毒症患者微循环功能的检测和及时干预治疗是改善预后的关键措施之一，同时也是重症医学领域研究的热点。
Abstract: Sepsis refers to serious organ dysfunction caused by dysregulation of body response caused by in-fection. The change of microcirculation function is an important pathophysiological mechanism of sepsis, and also an important factor affecting the prognosis of patients with sepsis. The detection and timely intervention of microcirculation function in patients with sepsis is one of the key measures to improve the prognosis, and is also a research hotspot in the field of critical care medi-cine.
文章引用：郭沛雨, 李秀, 单岩笙, 茅敏, 郭飞, 刘佳, 杨克鑫, 单亮. 脓毒症患者的微循环功能检测技术进展[J]. 临床医学进展, 2023, 13(1): 206-212. https://doi.org/10.12677/ACM.2023.131032

参考文献

[1] Ince, C. (2005) The Microcirculation Is the Motor of Sepsis. Critical Care, 9, S13-S19. [Google Scholar] [CrossRef] [PubMed]
[2] De Backer, D., Donadello, K., Sakr, Y., et al. (2013) Microcirculatory Altera-tions in Patients with Severe Sepsis: Impact of Time of Assessment and Relationship with Outcome. Critical Care Medi-cine, 41, 791-799. [Google Scholar] [CrossRef] 
[3] De Backer, D., Creteur, J., Preiser, J.C., et al. (2002) Mi-crovascular Blood Flow Is Altered in Patients with Sepsis. American Journal of Respiratory and Critical Care Medicine, 166, 98-104. [Google Scholar] [CrossRef] 
[4] Wijntjens, G.W., Fengler, K., Fuernau, G., et al. (2020) Prog-nostic Implications of Microcirculatory Perfusion versus Macrocirculatory Perfusion in Cardiogenic Shock: A Cul-prit-Shock Substudy. European Heart Journal. Acute Cardiovascular Care, 9, 108-119. [Google Scholar] [CrossRef] [PubMed]
[5] Hernández, G., Castro, R. and Bakker, J. (2020) Capillary Refill Time: The Missing Link between Macrocirculation and Microcirculation in Septic Shock? Journal of Thoracic Disease, 12, 1127-1129. [Google Scholar] [CrossRef] [PubMed]
[6] Zampieri, F.G., Damiani, L.P., Bakker, J., et al. (2020) Effects of a Resuscitation Strategy Targeting Peripheral Perfusion Status versus Serum Lactate Levels among Patients with Septic Shock. A Bayesian Reanalysis of the Andromeda-Shock Trial. American Journal of Respiratory and Critical Care Med-icine, 201, 423-429. [Google Scholar] [CrossRef] 
[7] Nguyen, H.B., Rivers, E.P., Knoblich, B.P., et al. (2004) Early Lactate Clearance Is Associated with Improved Outcome in Severe Sepsis and Septic Shock. Critical Care Medicine, 32, 1637-1642. [Google Scholar] [CrossRef] 
[8] Mallat, J., Pepy, F., Lemyze, M., et al. (2014) Central Venous-to-Arterial Carbon Dioxide Partial Pressure Difference in Early Resuscitation from Septic Shock: A Prospective Observational Study. European Journal of Anaesthesiology, 31, 371-380. [Google Scholar] [CrossRef] 
[9] Weinberger, J., Klompas, M. and Rhee, C. (2021) What Is the Utility of Measuring Lactate Levels in Patients with Sepsis and Septic Shock? Seminars in Respiratory and Critical Care Medicine, 42, 650-661. [Google Scholar] [CrossRef] [PubMed]
[10] Hernandez, G., Bellomo, R. and Bakker, J. (2019) The Ten Pitfalls of Lactate Clearance in Sepsis. Intensive Care Medicine, 45, 82-85. [Google Scholar] [CrossRef] [PubMed]
[11] Luiking, Y.C., Poeze, M. and Deutz, N.E. (2020) A Random-ized-Controlled Trial of Arginine Infusion in Severe Sepsis on Microcirculation and Metabolism. Clinical Nutrition, 39, 1764-1773. [Google Scholar] [CrossRef] [PubMed]
[12] 阮净, 张淑文, 袁振铎, 靳红, 王莘, 张宝红, 纪华, 罗薇. 动静脉血pH和二氧化碳分压差与胃粘膜pH监测组织氧合相关性的实验研究[J]. 中国危重病急救医学, 2000, 12(2): 109-112.
[13] 刘喜成, 张中军, 任永功. 混合静脉血氧饱和度监测的临床应用[J]. 中国急救医学, 2007, 27(1): 55-58.
[14] Chen, F., Tillberg, P.W. and Boyden, E.S. (2015) Optical Imaging. Expansion Microscopy. Science, 347, 543-548. [Google Scholar] [CrossRef] [PubMed]
[15] Mostany, R., Miquelajauregui, A., Shtrahman, M., et al. (2015) Two-Photon Excitation Microscopy and Its Applications in Neuroscience. Methods in Molecular Biology, 1251, 25-42. [Google Scholar] [CrossRef] [PubMed]
[16] Wolf, M., Ferrari, M. and Quaresima, V. (2007) Progress of Near-Infrared Spectroscopy and Topography for Brain and Muscle Clinical Applications. Journal of Biomedical Optics, 12, Article ID: 062104. [Google Scholar] [CrossRef] [PubMed]
[17] Donati, A., Damiani, E., Domizi, R., et al. (2016) Near-Infrared Spectroscopy for Assessing Tissue Oxygenation and Microvascular Reactivity in Critically Ill Patients: A Prospective Observational Study. Critical Care, 20, 311. [Google Scholar] [CrossRef] [PubMed]
[18] Mesquida, J., Gruartmoner, G. and Espinal, C. (2013) Skeletal Muscle Oxygen Saturation (StO2) Measured by Near- Infrared Spectroscopy in the Critically Ill Patients. BioMed Re-search International, 2013, Article ID: 502194. [Google Scholar] [CrossRef] [PubMed]
[19] Bickler, P., Feiner, J., Rollins, M. and Meng, L. (2017) Tissue Oximetry and Clinical Outcomes. Anesthesia & Analgesia, 124, 72-82. [Google Scholar] [CrossRef] 
[20] Domizi, R., Damiani, E., Scorcella, C., et al. (2019) Associ-ation between Sublingual Microcirculation, Tissue Perfusion and Organ Failure in Major Trauma: A Subgroup Analysis of a Prospective Observational Study. PLOS ONE, 14, e0213085. [Google Scholar] [CrossRef] [PubMed]
[21] Menezes, I.A.C., Cunha, C.L.D., Junior, H.C. and Luy, A.M. (2019) Increase of Perfusion Index during Vascular Occlusion Test Is Paradoxically Associated with Higher Mortality in Septic Shock after Fluid Resuscitation: A Prospective Study. Shock, 51, 605-612. [Google Scholar] [CrossRef] 
[22] Samraj, R.S., Lopez-Colon, D., Kerrigan, M., et al. (2019) Thenar Muscle Oxygen Saturation Using Vascular Occlusion Test: A Novel Technique to Study Microcirculatory Ab-normalities in Pediatric Heart Failure Patients. Pediatric Cardiology, 40, 1151-1158. [Google Scholar] [CrossRef] [PubMed]
[23] Boyle, N.H., Roberts, P.C., Ng, B., et al. (1999) Scanning Laser Doppler Is a Useful Technique to Assess Foot Cutaneous Perfusion during Femoral Artery Cannulation. Critical Care, 3, 95-100. [Google Scholar] [CrossRef] [PubMed]
[24] O’neil, M.P., Alie, R., Guo, L.R., et al. (2018) Microvascular Respon-siveness to Pulsatile and Nonpulsatile Flow during Cardiopulmonary Bypass. The Annals of Thoracic Surgery, 105, 1745-1753. [Google Scholar] [CrossRef] [PubMed]
[25] Groner, W., Winkelman, J.W., Harris, A.G., et al. (1999) Orthogonal Polarization Spectral Imaging: A New Method for Study of the Microcirculation. Nature Medicine, 5, 1209-1212. [Google Scholar] [CrossRef] [PubMed]
[26] Krupičková, P., Mormanová, Z., Bouček, T., et al. (2018) Micro-vascular Perfusion in Cardiac Arrest: A Review of Microcirculatory Imaging Studies. Perfusion, 33, 8-15. [Google Scholar] [CrossRef] [PubMed]
[27] Holmgaard, F., Vedel, A.G., Ravn, H.B., et al. (2018) Impact of Mean Arterial Pressure on Sublingual Microcirculation during Cardiopulmonary Bypass-Secondary Outcome from a Randomized Clinical Trial. Microcirculation, 25, e12459. [Google Scholar] [CrossRef] [PubMed]
[28] Rovas, A., Lukasz, A.H., Vink, H., et al. (2018) Bedside Analysis of the Sublingual Microvascular Glycocalyx in the Emergency Room and Intensive Care Unit—The GlycoNurse Study. Scandinavian Journal of Trauma, Resuscitation and Emergen-cy Medicine, 26, 16. [Google Scholar] [CrossRef] [PubMed]
[29] Santos, D.M.D., Quintans, J.S.S., Quin-tans-Junior, L.J., et al. (2019) Association between Peripheral Perfusion, Microcirculation and Mortality in Sepsis: A Systematic Review. Brazilian Journal of Anesthesiology, 69, 605-621. [Google Scholar] [CrossRef] [PubMed]
[30] Van Elteren, H.A., Ince, C., Tibboel, D., et al. (2015) Cutaneous Microcirculation in Preterm Neonates: Comparison between Sidestream Dark Field (SDF) and Incident Dark Field (IDF) Imaging. Journal of Clinical Monitoring and Computing, 29, 543-548. [Google Scholar] [CrossRef] [PubMed]
[31] Donati, A., Domizi, R., Damiani, E., et al. (2013) From Macro-hemodynamic to the Microcirculation. Critical Care Research and Practice, 2013, Article ID: 892710. [Google Scholar] [CrossRef] [PubMed]
[32] Tanaka, S., Harrois, A. and Duranteau, J. (2014) Leukodepleted versus Nonleukodepleted Red Blood Cell Transfusion in Septic Patients: A Microcirculatory Vision. Critical Care, 18, 128. [Google Scholar] [CrossRef] [PubMed]
[33] Spronk, P.E., Zandstra, D.F. and Ince, C. (2004) Bench-to-Bedside Review: Sepsis Is a Disease of the Microcirculation. Critical Care, 8, 462-468. [Google Scholar] [CrossRef] [PubMed]
[34] Ince, C., Boerma, E.C., Cecconi, M., et al. (2018) Second Consensus on the Assessment of Sublingual Microcirculation in Criti-cally Ill Patients: Results from a Task Force of the European Society of Intensive Care Medicine. Intensive Care Medicine, 44, 281-299. [Google Scholar] [CrossRef] [PubMed]
[35] Vellinga, N.A., Boerma, E.C., Koopmans, M., et al. (2015) International Study on Microcirculatory Shock Occurrence in Acutely Ill Patients. Critical Care Medicine, 43, 48-56. [Google Scholar] [CrossRef] 
[36] Van Der Voort, P.H., Van Zanten, M., Bosman, R.J., et al. (2015) Testing a Conceptual Model on Early Opening of the Microcirculation in Severe Sepsis and Septic Shock: A Randomised Controlled Pilot Study. European Journal of Anaesthesiology, 32, 189-198. [Google Scholar] [CrossRef] 
[37] 汪燕, 虞意华, 刘秉宇, 颜默磊, 严静. 微血管流动指数对老年严重脓毒症患者预后的预测作用[J]. 心脑血管病防治, 2016, 16(3): 197-199+207.
[38] Mohamed, H., Hosny, H., Tawadros, P., et al. (2019) Effect of Dexmedetomidine Infusion on Sublingual Microcirculation in Patients Undergoing On-Pump Coronary Artery Bypass Graft Surgery: A Prospective Randomized Trial. Journal of Cardiotho-racic and Vascular Anesthesia, 33, 334-340. [Google Scholar] [CrossRef] [PubMed]
[39] Zuccari, S., Damiani, E., Domizi, R., et al. (2020) Changes in Cytokines, Haemodynamics and Microcirculation in Patients with Sepsis/Septic Shock Undergoing Continuous Renal Replacement Therapy and Blood Purification with CytoSorb. Blood Purification, 49, 107-113. [Google Scholar] [CrossRef] [PubMed]
[40] Donati, A., Damiani, E., Luchetti, M., et al. (2014) Micro-circulatory Effects of the Transfusion of Leukodepleted or Non-Leukodepleted Red Blood Cells in Patients with Sepsis: A Pilot Study. Critical Care, 18, R33. [Google Scholar] [CrossRef] [PubMed]
[41] Sakr, Y., Dubois, M.J., De Backer, D., et al. (2004) Persistent Microcircula-tory Alterations Are Associated with Organ Failure and Death in Patients with Septic Shock. Critical Care Medicine, 32, 1825-1831. [Google Scholar] [CrossRef] 
[42] Trzeciak, S., Glaspey, L.J., Dellinger, R.P, et al. (2014) Randomized Controlled Trial of Inhaled Nitric Oxide for the Treatment of Microcirculatory Dysfunction in Pa-tients with Sepsis. Critical Care Medicine, 42, 2482-2492. [Google Scholar] [CrossRef] 
[43] Hernandez, G., Bruhn, A. and Ince, C. (2013) Microcircu-lation in Sepsis: New Perspectives. Current Vascular Pharmacology, 11, 161-169. [Google Scholar] [CrossRef] [PubMed]
[44] Kanoore Edul, V.S., Dubin, A. and Ince, C. (2011) The Mi-crocirculation as a Therapeutic Target in the Treatment of Sepsis and Shock. Seminars in Respiratory and Critical Care Medicine, 32, 558-568. [Google Scholar] [CrossRef] [PubMed]

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