炎症因子C-反应蛋白和白介素-6在缺血性脑卒中的研究进展
Research Progress of Inflammatory Factors C-Reactive Protein and Interleukin-6 in Ischemic Stroke
摘要: 缺血性脑卒中是一种病因复杂的综合征，其中炎症反应参与其发病机制的全程。分子生物学、流行病学证据表明CRP和IL-6在脑卒中发病的病理生理机制中具有重要作用，影响缺血性卒中的发生、发展及预后。本综述从分子生物学、流行病学和新近开展的临床研究阐述CRP和IL-6在缺血性脑卒中发生发展及预后中的作用和意义。
Abstract: Ischemic stroke is a syndrome with complex etiology, in which inflammatory response is involved in the whole process of its pathogenesis. Molecular biology and epidemiological evidence show that CRP and IL-6 play an important role in the pathophysiology of stroke and affect the occurrence, de-velopment and prognosis of ischemic stroke. This review summarizes the role and significance of CRP and IL-6 in the development and prognosis of ischemic stroke from the perspectives of molecu-lar biology, epidemiology and recent clinical studies.
文章引用：潘树超, 汪元浚. 炎症因子C-反应蛋白和白介素-6在缺血性脑卒中的研究进展[J]. 临床医学进展, 2023, 13(1): 232-237. https://doi.org/10.12677/ACM.2023.131036

参考文献

[1] 王陇德, 彭斌, 张鸿祺, 王伊龙, 刘鸣, 单春雷, 曹雷, 王凌霄, 谢薇, 王培健, 马林. 《中国脑卒中防治报告2020》概要[J]. 中国脑血管病杂志, 2022, 19(2): 136-144.
[2] Thayabaranathan, T., et al. (2022) Global Stroke Statistics 2022. International Journal of Stroke, 17, 946-956. [Google Scholar] [CrossRef] [PubMed]
[3] 杨美丽, 蔡若蔚. 阻塞性睡眠呼吸暂停综合征和缺血性脑卒中的炎性反应[J]. 医学综述, 2010, 16(6): 919-921.
[4] Zeng, Z., Liu, Y., Zheng, W., et al. (2019) Mi-croRNA-129-5p Alleviates Nerve Injury and Inflammatory Response of Alzheimer’s Disease via Downregulating SOX6. Cell Cycle, 18, 3095-3110. 3095-3110． [Google Scholar] [CrossRef] [PubMed]
[5] 王海明, 李绍旦, 王茂云. 疏肝和胃方治疗肿瘤相关性抑郁临床研究[J]. 中国中医药信息杂志, 2017, 24(11): 22-25.
[6] 张珊, 赵静洁, 李丽. 免疫炎症与抑郁症[J]. 中华行为医学与脑科学杂志, 2019, 28(7): 660-665.
[7] 王旭生, 朱欣茹, 张朝辉, 宋景贵. 卒中后抑郁与炎症因子的关系研究[J]. 中国卒中杂志, 2020, 15(5): 532-536.
[8] Wen, H., Weymann, K.B., Wood, L. and Wang, Q.M. (2018) Inflammatory Signaling in Post-Stroke Fatigue and Depression. European Neurology, 80, 138-148. [Google Scholar] [CrossRef] [PubMed]
[9] Hasumi, K. and Suzuki, E. (2021) Impact of SMTP Targeting Plasminogen and Soluble Epoxide Hydrolase on Thrombolysis, Inflammation, and Ischemic Stroke. International Journal of Molecu-lar Sciences, 22, Article No. 954. [Google Scholar] [CrossRef] [PubMed]
[10] Liu, X., Ma, Y., Ouyang, R., et al. (2020) The Relationship between In-flammation and Neurocognitive Dysfunction in Obstructive Sleep Apnea Syndrome. Journal of Neuroinflammation, 17, Article No. 229. [Google Scholar] [CrossRef] [PubMed]
[11] Moutachakkir, M., Hanchi, A.L., Baraou, A., Boukhira, A. and Chellak, S. (2017) Caractéristiques Immunoanalytiques de la Protéine C-Réactive et de la Protéine C-Réactive Ultrasensi-ble. Annales de Biologie Clinique, 75, 225-229. [Google Scholar] [CrossRef] [PubMed]
[12] Moriya, J. (2019) Critical Roles of Inflammation in Atherosclerosis. Journal of Cardiology, 73, 22-27. [Google Scholar] [CrossRef] [PubMed]
[13] Mazaheri, S., Reisi, E., Poorolajal, J. and Ghiasian, M. (2018) C-Reactive Protein Levels and Clinical Outcomes in Stroke Patients: A Prospective Cohort Study. Archives of Iranian Medicine, 21, 8-12.
[14] Rose-John, S. (2018) Interleukin-6 Family Cytokines. Cold Spring Harbor Perspectives in Bi-ology, 10, Article ID: a028415. [Google Scholar] [CrossRef] [PubMed]
[15] Tanaka, T., Narazaki, M. and Kishimoto, T. (2018) Interleukin (IL-6) Immunotherapy. Cold Spring Harbor Perspectives in Biology, 10, Article ID: a028456. [Google Scholar] [CrossRef] [PubMed]
[16] Tyrrell, D.J. and Goldstein, D.R. (2021) Ageing and Atherosclerosis: Vascular Intrinsic and Extrinsic Factors and Potential Role of IL-6. Nature Reviews Cardiology, 18, 58-68. [Google Scholar] [CrossRef] [PubMed]
[17] Zhang, J., Wu, Y. and Gao, Z. (2019) Correlations of C-Reactive Protein (CRP), Interleukin-6 (IL-6), and Insulin Resistance with Cerebral Infarction in Hypertensive Patients. Medical Science Monitor, 25, 1506-1511. [Google Scholar] [CrossRef] 
[18] Kheirandish-Gozal, L. and Gozal, D. (2019) Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines. International Journal of Molecular Sciences, 20, Article No. 459. [Google Scholar] [CrossRef] [PubMed]
[19] Armstead, W.M., Hekierski, H., Pastor, P., et al. (2019) Release of IL-6 after Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis through NMDA Re-ceptor Activation and Upregulation of ET-1 and JNK. Translational Stroke Research, 10, 104-111. [Google Scholar] [CrossRef] [PubMed]
[20] 赵宏伟. 依达拉奉治疗急性脑梗死的临床有效率及对氧化应激和炎症因子的影响研究[J]. 黑龙江医学, 2019, 43(6): 627-628.
[21] 周巍, 马晓峰. 心房颤动合并脑卒中患者外周血RBP、IL-6表达及临床意义[J]. 湖南师范大学学报(医学版), 2021, 18(6): 21-24.
[22] 王红. 丁苯酞联合阿替普酶静脉溶栓治疗高龄ACI的效果及对相关指标的影响[J]. 中国医学创新, 2022, 19(26): 11-15.
[23] Wang, H., et al. (2022) An Evaluation of the Efficacy and Safety of Thrombolysis in Patients with Wake-up Stroke Using the Combination of Inflammatory Factors Interleukin-6 and C-Reactive Protein with Multi-Mode Magnetic Resonance Im-aging. Clinical Neurology and Neurosurgery, 221, Article ID: 107392. [Google Scholar] [CrossRef] [PubMed]
[24] Mu, Y., Wang, Z., Zhou, J., et al. (2018) Correlations of Post-Stroke Depression with Inflammatory Response Factors. Iranian Journal of Public Health, 47, 988-993.
[25] Yang, R.-R., et al. (2016) The Relationship between High-Sensitivity C-Reactive Protein at Admission and Post Stroke Depression: A 6-Month Follow-up Study. International Journal of Geriatric Psychiatry, 31, 231-239. [Google Scholar] [CrossRef] [PubMed]
[26] Felger, J.C., Li, Z., Haroon, E., et al. (2016) Inflammation Is Associated with Decreased Functional Connectivity within Corticostriatal Reward Circuitry in Depression. Molecular Psychiatry, 21, 1358-1365. [Google Scholar] [CrossRef] [PubMed]
[27] 彭松, 刘婧, 吴康, 罗明晶, 李瑞麟. 血清白介素-6、神经丝轻链蛋白及生长分化因子-15联合检测在脑卒中后抑郁诊断中的临床价值[J]. 热带医学杂志, 2021, 21(8): 992-995+1029.
[28] 王浩, 张莹, 许啟伍, 李其英, 丁婷, 潘树超. C反应蛋白与白细胞介素-6对急性脑梗死复发风险预测价值[J]. 临床军医杂志, 2022, 50(6): 645-648. [Google Scholar] [CrossRef] 
[29] 刘硕. 瑞舒伐他汀对老年血管性痴呆患者氧化应激及血清IL-6、IL-1β、TNF-α水平的影响[J]. 中国实用医药, 2022, 17(4): 165-167. [Google Scholar] [CrossRef] 
[30] 吴章薇, 张通, 赵军, 张国军, 邵春青. 急性缺血性卒中后炎症因子水平与神经功能恢复的关系研究[J]. 中国卒中杂志, 2021, 16(10): 1023-1028.
[31] 王红. 脑卒中后肺部感染患者炎症细胞因子、免疫功能变化及影响因素分析[J]. 中国医学创新, 2022, 19(21): 150-154.
[32] 彭海莹, 解翠环. 血清hs-CRP、NGAL检测对脑卒中患者肺部感染预后临床意义[J]. 中华肺部疾病杂志(电子版), 2021, 14(2): 201-204.
[33] Yang, C., Hawkins, K.E., Doré, S. and Candelario-Jalil, E. (2019) Neuroinflammatory Mechanisms of Blood-Brain Barrier Damage in Ischemic Stroke. American Journal of Physi-ology-Cell Physiology, 316, C135-C153. [Google Scholar] [CrossRef] [PubMed]
[34] Kenigsberg, B.B., Barnett, C.F., Mai, J.C. and Chang, J.J. (2019) Neurogenic Stunned Myocardium in Severe Neurological Injury. Current Neurology and Neuroscience Reports, 19, Ar-ticle No. 90. [Google Scholar] [CrossRef] [PubMed]

为你推荐