氨甲环酸在骨科围手术期中的应用研究进展
Application of Tranexamic Acid in Orthopedic Perioperative Period
DOI: 10.12677/ACM.2023.131055, PDF,    科研立项经费支持
作者: 刘相旭, 王冠兴：济宁医学院临床医学院，山东 济宁；李彦明*：济宁医学院附属医院脊柱外科，山东 济宁
关键词: 氨甲环酸；围术期；止血；给药方式；副作用；Tranexamic Acid； Perioperative Period； Hemostasis； Method of Administration； Side Effects
摘要: 纤溶是止血过程中的重要组成部分，而氨甲环酸早已被证明是一种抗纤溶的有效药物，可以竞争性抑制纤溶酶原使血凝块的溶解减少从而发挥止血作用。目前氨甲环酸作为止血剂已经被应用于诸如骨科手术、普通外科手术、心脏手术和妇产科手术等手术的围术期之中。由于血源的紧缺，手术中的失血问题是骨科医师关注的极其重要的问题，近年来，氨甲环酸在骨科围术期中的应用越来越多，越来越普遍。本篇综述主要探讨氨甲环酸在骨科围手术期中的作用、给药方式、副作用、与其他药物联合使用的情况及其潜在价值。
Abstract: Fibrinolysis is an important part of the process of hemostasis, and tranexamic acid has long been proven to be an effective anti-fibrinolytic drug, which can competitively inhibit plasminogen to re-duce the dissolution of blood clots and play a hemostatic effect. At present, tranexamic acid as a hemostatic agent has been used in the perioperative period of operations such as orthopedic sur-gery, general surgery, heart surgery, and obstetrics and gynecology surgery. Due to the shortage of blood sources, the problem of blood loss during surgery is an important and important issue for or-thopedic surgeons. In recent years, tranexamic acid has been used more and more commonly in the perioperative period of orthopedics. This review mainly discusses the role of tranexamic acid in the perioperative period of orthopedics, administration methods, side effects, combined use of other drugs and its potential value.
文章引用：刘相旭, 王冠兴, 李彦明. 氨甲环酸在骨科围手术期中的应用研究进展[J]. 临床医学进展, 2023, 13(1): 362-368. https://doi.org/10.12677/ACM.2023.131055

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