矮小症儿童和青少年出生体重与血清尿酸的相关性
Associations between Birth Weight and Serum Uric Acid in Children with Short Stature
DOI: 10.12677/ACM.2023.131057, PDF,   
作者: 马 晨*, 杨如雪：济宁医学院临床医学院，山东 济宁；张 梅, 刘福朋, 李艳英, 班 博#, 汲宝兰#：济宁医学院附属医院内分泌科，山东 济宁；中国生长发育行为医学研究中心，山东 济宁
关键词: 矮小症；低出生体重；高尿酸血症；Short Stature； Low Birth Weight； High Uric Acid
摘要: 目的：探究矮小症儿童和青少年出生体重(BW)与血清尿酸(UA)之间的相关性。方法：选取2013年03月至2019年02月在济宁医学院附属医院内分泌科就诊的矮小症儿童和青少年共478人，以BW 2.5 kg为切点，将受试者分为低出生体重(LBW定义为出生体重 < 2.5 kg)组和正常出生体重(NBW定义为出生体重 ≥ 2.5 kg，且≤4.0 kg)组。收集其出生信息及住院资料，分析矮小症儿童和青少年BW与UA之间的相关性。结果：LBW组UA水平显著高于NBW组(P < 0.05)，高尿酸血症(HUA)组体重指数(BMI)、LBW (%)显著高于非HUA组(P < 0.05)，HUA组BW显著低于非HUA组(P < 0.05)，Logistic回归分析显示BW、BMI是HUA的独立危险因素。结论：在矮小症儿童和青少年中，较低的出生体重与HUA的发病风险密切相关。
Abstract: Objective: To explore the relationship between birth weight (BW) and serum uric acid (UA) in chil-dren and adolescents with short stature. Methods: A total of 478 children and adolescents with short stature who were admitted to Endocrinology Department of Affiliated Hospital of Jining Medi-cal University from March 2013 to February 2019 were selected. The cut-off point was BW 2.5 kg. Subjects were divided into low birth weight (LBW defined as birth weight < 2.5 kg) group and nor-mal birth weight (NBW defined as birth weight ≥ 2.5 kg, and ≤ 4.0 kg) group. Data of birth and hos-pitalization were collected to analyze the correlation between BW and UA in children and adoles-cents with short stature. Results: The UA level in LBW group was significantly higher than that in NBW group (P < 0.05), body mass index (BMI) and LBW (%) in hyperuricemia (HUA) group were significantly higher than those in non-HUA group (P < 0.05), and BW in HUA group was significantly lower than that in non-HUA group (P < 0.05). Logistic regression analysis showed that BW and BMI were independent risk factors for HUA. Conclusion: Lower birth weight is associated with the risk of HUA in children and adolescents with short stature.
文章引用：马晨, 张梅, 杨如雪, 刘福朋, 李艳英, 班博, 汲宝兰. 矮小症儿童和青少年出生体重与血清尿酸的相关性[J]. 临床医学进展, 2023, 13(1): 375-381. https://doi.org/10.12677/ACM.2023.131057

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