miRNA-200c和E-Cadherin在三阴性乳腺癌中的表达及意义
Expression and Clinical Significance of miRNA-200 and E-Cadherin in Triple Negative Breast Carcinoma
DOI: 10.12677/ACM.2023.131069, PDF,    科研立项经费支持
作者: 彭 湃, 郑 凯, 陈梦荷, 胡超华, 韩运涛*：武汉科技大学附属孝感医院普外科，湖北 孝感
关键词: 三阴性乳腺癌；荧光定量PCR；临床病理学；转移；TNBC； Fluorescent Quantitation PCR； Clinicopathology； Metastasis
摘要: 目的：探讨miRNA-200c和E-cadherin在三阴性乳腺癌(TNBC)中的表达及临床意义。方法：用荧光定量PCR检测60例TNBC组织及50例正常乳腺组织中miRNA-200c和E-cadherin的表达，分析其表达与TNBC临床病理特征的关系。结果：miRNA-200c和E-cadherin在TNBC组织中的表达水低于正常乳腺组织(P < 0.05)，其表达与TNBC的临床分期、组织学分级及淋巴结转移相关(P < 0.05)。miRNA-200c和E-cadherin在TNBC中的表达呈正相关(P < 0.05)。结论：miRNA-200c和E-cadherin可能参与TNBC的进展及转移过程，可能成为新的肿瘤标志物。
Abstract: Objective: To investigate the expression and clinical significance of miRNA-200c and E-cadherin in triple negative breast cancer (TNBC). Methods: The expression of miRNA-200c and E-cadherinin in 60 TNBC tissues and 50 normal tissues was detected by fluorescent quantitation PCR, and the cor-relation between its expression and clinicopathological features of TNBC was analyzed. Results: The expression level of miRNA-200and E-cadherinin in TNBC tissue was significantly lower than that in normal breast tissue (P < 0.05), and its expression was correlated with lymph node metastasis, tu-mor stage, histological grade in TNBC tissue (P < 0.05). There was a positive correlation between miRNA-200c and E-cadherin expression in TNBC (P < 0.05). Conclusions: miRNA-200c and E-cadherin may be involved in the development and metastasis of TNBC, and may become new tu-mor markers.
文章引用：彭湃, 郑凯, 陈梦荷, 胡超华, 韩运涛. miRNA-200c和E-Cadherin在三阴性乳腺癌中的表达及意义[J]. 临床医学进展, 2023, 13(1): 467-473. https://doi.org/10.12677/ACM.2023.131069

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