肝切除术后肝功能衰竭预测的研究进展
Advances in the Prediction of Post Hepatectomy Liver Failure
DOI: 10.12677/ACM.2023.131072, PDF,   
作者: 邹儒川, 任 宾*, 李 枫:青海大学,青海 西宁;青海大学附属医院,青海 西宁
关键词: 肝切除术肝功能衰竭肝细胞预测Hepatectomy Liver Failure Cancer Liver Cell Prediction
摘要: 吲哚菁绿15 min滞留率(ICG-R15)、肝脏体积测定是目前临床上常用的术前肝功能评估方法,但在临床应用过程中只作为单一的肝功能评估指标,存在一定的局限性,而两者相联合可以更加精确地评估肝脏的各段功能,从而极大地提高了手术的安全性和有效性。通过查阅相关文献资料并结合文献要点对在肝切除术后肝功能衰竭(PHLF)预测的相关研究进展进行综述。
Abstract: Indocyanine green 15 min retention rate (ICG-R15) and liver volume measurement are currently commonly used in preoperative liver function evaluation methods, but in clinical application, they are only used as a single liver function evaluation index, which has certain limitations. However, the combination of the two can more accurately evaluate the function of each segment of the liver. Thus, the safety and effectiveness of the operation are greatly improved. This paper reviews the research progress on the prediction of PHLF by referring to the relevant literature and combining the key points of the literature.
文章引用:邹儒川, 任宾, 李枫. 肝切除术后肝功能衰竭预测的研究进展[J]. 临床医学进展, 2023, 13(1): 484-491. https://doi.org/10.12677/ACM.2023.131072

参考文献

[1] Uttley, L., Indave, B.I., Hyde, C., et al. (2020) Invited Commentary—WHO Classification of Tumors: How Should Tu-mours Be Classified? Expert Consensus, Systematic Reviews or Both. International Journal of Cancer, 146, 3516- 3521. [Google Scholar] [CrossRef] [PubMed]
[2] Villanueva, A. (2019) Hepatocellular Carcinoma. The New England Journal of Medicine, 380, 1450-1462. [Google Scholar] [CrossRef
[3] Zhong, J., et al. (2014) Hepatic Resection Associated with Good Survival for Selected Patients with Intermediate and Advanced-Stage Hepatocellular Carcinoma. Annals of Surgery, 260, 329-340. [Google Scholar] [CrossRef
[4] Emmanuel, M., Martin, H., Michael, S., et al. (2016) Guide-lines for Perioperative Care for Liver Surgery: Enhanced Recovery after Surgery (ERAS) Society Recommendations. World Journal of Surgery, 40, 2425-2440. [Google Scholar] [CrossRef] [PubMed]
[5] Schreckenbach, T., Liese, J., Bechstein, W.O. and Moench, C. (2012) Posthepatectomy Liver Failure. Digestive Surgery, 29, 79-85. [Google Scholar] [CrossRef] [PubMed]
[6] Rahbari, N.N., James, G.O., Robert, P., et al. (2011) Post-Hepatectomy Haemorrhage: A Definition and Grading by the International Study Group of Liver Surgery (ISGLS). HPB (Oxford), 13, 528-535. [Google Scholar] [CrossRef] [PubMed]
[7] Eguchi, H., Umeshita, K., Sakon, M., et al. (2000) Pres-ence of Active Hepatitis Associated with Liver Cirrhosisis a Risk Factor for Mortality Caused by Posthepatectomy Liver Failure. Digestive Diseases and Sciences, 45, 1383-1388. [Google Scholar] [CrossRef
[8] Yoo, H.Y., Edwin, D. and Thuluvath, P.J. (2003) Relationship of the Model for End-Stage Liver Disease (MELD) Scale to Hepatic Encephalopathy, as Defined by Electroencephalography and Neuropsychometric Testing, and Ascites. The American Journal of Gastroenterology, 98, 1395-1399. [Google Scholar] [CrossRef] [PubMed]
[9] Balzan, S., Belghiti, J., Farges, O., et al. (2005) The “50-50 Criteria” on Postoperative Day 5: An Accurate Predictor of Liver Failure and Death after Hepatectomy. Annals of Surgery, 242, 824-828. [Google Scholar] [CrossRef] [PubMed]
[10] Rahbari, N.N., Garden, O.J., Padbury, R., et al. (2011) Posthepatectomy Liver Failure: A Definition and Grading by the International Study Group of Liver Surgery (ISGLS). Surgery, 149, 713-724. [Google Scholar] [CrossRef] [PubMed]
[11] Catherine, P., Sylvie, J., Didier, D., et al. (2009) Prospective Vali-dation of the “Fifty-Fifty” Criteria as an Early and Accurate Predictor of Death after Liver Resection in Intensive Care Unit Patients. Annals of Surgery, 249, 124-128. [Google Scholar] [CrossRef
[12] van den Broek, M.A.J., Olde, D., Dejong, C.H.C., et al. (2008) Liver Failure after Partial Hepatic Resection: Definition, Pathophysiology, Risk Factors and Treatment. Liver In-ternational, 28, 767-780. [Google Scholar] [CrossRef] [PubMed]
[13] Yuen, M.F., et al. (2009) Hepatocellular Carcinoma in the Asia Pacific Region. Journal of Gastroenterology and Hepatology, 24, 346-353. [Google Scholar] [CrossRef] [PubMed]
[14] Jordi, B. and Morris, S. (2011) Management of Hepatocel-lular Carcinoma: An Update. Hepatology (Baltimore, Md), 9, 452-463.
[15] Alessandro, C., Giorgio, E., Matteo, C., et al. (2006) Recovery from Liver Failure after Hepatectomy for Hepatocellular Carcinoma in Cirrhosis: Meaning of the Model for End-Stage Liver Disease. Journal of the American College of Surgeons, 203, 670-676. [Google Scholar] [CrossRef] [PubMed]
[16] Wang, Y.Y., et al. (2016) Albumin-Bilirubin versus Child-Pugh Score as a Predictor of Outcome after Liver Resection for Hepatocellular Carcinoma. British Journal of Sur-gery, 103, 725-734. [Google Scholar] [CrossRef] [PubMed]
[17] Zou, H., et al. (2018) A Comparative Study of Albu-min-Bilirubin Score with Child-Pugh Score, Model for End-Stage Liver Disease Score and Indocyanine Green R15 in Predicting Posthepatectomy Liver Failure for Hepatocellular Carcinoma Patients. Digestive Diseases (Basel, Switzerland), 36, 236-243. [Google Scholar] [CrossRef] [PubMed]
[18] Tsuyoshi, I., Takahiro, U., Shigekazu, T., et al. (2009) A Simple, Noninvasively Determined Index Predicting Hepatic Failure Following Liver Resection for Hepatocellular Car-cinoma. Journal of Hepato-Biliary-Pancreatic Sciences, 16, 42-48. [Google Scholar] [CrossRef] [PubMed]
[19] Xu, L., et al. (2015) Prognostic Nomogram for Patients with Un-resectable Hepatocellular Carcinoma after Transcatheter Arterial Chemoembolization. Journal of Hepatology, 63, 122-130. [Google Scholar] [CrossRef] [PubMed]
[20] Ganne-Carrié, N., Layese, R., Bourcier, V., et al. (2016) Nomo-gram for Individualized Prediction of Hepatocellular Carcinoma Occurrence in Hepatitis C Virus Cirrhosis (ANRS CO12 CirVir). Hepatology, 64, 1136-1147. [Google Scholar] [CrossRef] [PubMed]
[21] François, D. and Dominique, V. (2005) Assessment of the Prognosis of Cirrhosis: Child-Pugh versus MELD. Journal of Hepatology, 42, S100-S107. [Google Scholar] [CrossRef] [PubMed]
[22] Russell, W., Erick, E., Richard, F., et al. (2003) Model for End-Stage Liver Disease (MELD) and Allocation of Donor Livers. Gastroenterology, 124, 91-96. [Google Scholar] [CrossRef] [PubMed]
[23] Teh-Ia H, Han-Chieh L, Cheng-Yuan H, et al. (2007) The Model for End-Stage Liver Disease-Based Cancer Staging Systems Are Better Prognostic Models for Hepatocellular Carcinoma: A Prospective Sequential Survey. The American Journal of Gastroenterology, 102, 1920-1930. [Google Scholar] [CrossRef] [PubMed]
[24] Johnson, P.J., Sarah, B., Chiaki, K., et al. (2015) Assess-ment of Liver Function in Patients with Hepatocellular Carcinoma: A New Evidence-Based Approach—The ALBI Grade. Journal of Clinical Oncology, 33, 550-558. [Google Scholar] [CrossRef
[25] Lau, W., Leung, K., Leung, T.W., et al. (1997) A Logical Ap-proach to Hepatocellular Carcinoma Presenting with Jaundice. Annals of Surgery, 225, 281-285. [Google Scholar] [CrossRef] [PubMed]
[26] Liu, P.H., et al. (2017) ALBI and PALBI Grade Predict Survival for HCC across Treatment Modalities and BCLC Stages in the MELD Era. Journal of Gastroenterology and Hepatology, 32, 879-886. [Google Scholar] [CrossRef] [PubMed]
[27] Mai, R.Y., Ye, J.Z., Long, Z.R., et al. (2019) Preoperative Aspartate Minotransferase-to-Platelet-Ratio Index as a Predictor of Posthepatectomy Liver Failure for Re-sectable Hepatocellular Carcinoma. Cancer Management and Research, 11, 1401-1414. [Google Scholar] [CrossRef
[28] Le Roy, B., Gregoire, E., Cosse, C., et al. (2018) Indocyanine Green Retention Rates at 15 min Predicted Hepatic Decompensation in a Western Population. World Journal of Surgery 42, 2570-2578. [Google Scholar] [CrossRef] [PubMed]
[29] Wakabayashi, H., Yachida, S., Maeba, T. and Maeta, H. (2002) Evaluation of Liver Function for the Application of Preoperative Portal Vein Embolization on Major Hepatic Resection. Hepatogastroenterology, 49, 1048-1052.
[30] Yokoyama, Y., Ebata, T., Igami, T., et al. (2016) The Predictive Value of Indocyaninegreen Clearance in Future Liver Remnant for Posthepatectomy Liver Failure Following Hepatectomy with Extrahepatic Bile Duct Resection. World Journal of Surgery 40, 1440-1447. [Google Scholar] [CrossRef] [PubMed]
[31] Torzilli, G., Makuuchi, M., Inoue, K., Takayama T, et al. (1999) No-Mortality Liver Resection for Hepatocellular Carcinoma in Cirrhotic and Noncirrhotic Patients: Is There a Way? A Prospective Analysis of Our Approach. The Archives of Surgery, 134, 984-992. [Google Scholar] [CrossRef] [PubMed]
[32] Maruyama, M., Yoshizako, T., Araki, H., et al. (2018) Future Liver Remnant Indocyanine Green Plasma Clearance Rate as a Predictor of Post-Hepatectomy Liver Failure after Portal Vein Embolization. CardioVascular and Interventional Radiology, 41, 1877-1884. [Google Scholar] [CrossRef] [PubMed]
[33] Hwang, S., Ha, T.Y., Song, G.W., et al. (2015) Quantified Risk Assessment for Major Hepatectomy via the Indocyanine Green Clearance Rate and Liver Volumetry Combined with Standard Liver Volume. Journal of Gastrointestinal Surgery 19, 1305-1314. [Google Scholar] [CrossRef] [PubMed]
[34] Yada, K., Morine, Y., Ishibashi, H., et al. (2018) Treatment Strategy for Successful Hepatic Resection of Icteric Liver. The Journal of Medical Investigation, 65, 37-42. [Google Scholar] [CrossRef] [PubMed]
[35] Wagener, G. (2013) Assessment of Hepatic Function, Operative Candidacy, and Medical Management after Liver Resection in the Patient with Underlying Liver Disease. Seminars in Liver Disease, 33, 204-212. [Google Scholar] [CrossRef] [PubMed]
[36] Rassam, F., Olthof, P.B., Bennink, R.J. and van Gulik, T.M. (2017) Current Modalities for the Assessment of Future Remnant Liver Function. Visceral Medicine 33, 442-448. [Google Scholar] [CrossRef] [PubMed]
[37] Mizutani, Y., Hirai, T., Nagamachi, S., et al. (2018) Prediction of Posthepatectomy Liver Failure Proposed by the International Study Group of Liver Surgery: Residual Liver Function Es-timation with 99mTc-Galactosyl Human Serum Albumin Scintigraphy. Clinical Nuclear Medicine, 43, 77-81. [Google Scholar] [CrossRef
[38] Yoshida, M., Shiraishi, S., Sakamoto, F., et al. (2014) As-sessment of Hepatic Functional Regeneration after Hepatectomy Using (99m) Tc-GSA SPECT/CT Fused Imaging. An-nals of Nuclear Medicine, 28, 780-788. [Google Scholar] [CrossRef] [PubMed]
[39] Nakamura, I., Iimuro, Y., Hai, S., et al. (2018) Impaired Value of 99m Tc-GSA Scintigraphy as an Independent Risk Factor for Posthepatectomy Liver Failure in Patients with Hepatocel-lular Carcinoma. European Surgical Research, 59, 12-22. [Google Scholar] [CrossRef] [PubMed]
[40] Mizuguchi, T., Kawamoto, M., Meguro, M., Hui, T.T. and Hirata, K. (2014) Preoperative Liver Function Assessments to Estimate the Prognosis and Safety of Liver Resections. Surgery Today, 44, 1-10. [Google Scholar] [CrossRef] [PubMed]
[41] Cieslak, K.P., Runge, J.H., Heger, M., et al. (2014) New Perspec-tives in the Assessment of Future Remnant Liver. Digestive Surgery, 31, 255-268. [Google Scholar] [CrossRef] [PubMed]
[42] de Graaf, W., van Lienden, K.P., Dinant, S., et al. (2010) Assessment of Future Remnant Liver Function Using Hepatobiliary Scintigraphy in Patients Undergoing Major Liver Resection. Journal of Gastrointestinal Surgery, 14, 369-378. [Google Scholar] [CrossRef] [PubMed]
[43] Rassam, F., Olthof, P.B., Richardson, H., et al. (2019) Practical Guidelines for the Use of Technetium-99m Mebrofenin Hepatobiliary Scintigraphy in the Quantitative Assessment of Liver Function. Nuclear Medicine Communications, 40, 297-307. [Google Scholar] [CrossRef
[44] Chapelle, T., Op de Beeck, B., Roeyen, G., et al. (2017) Measuring Future Liver Remnant Function Prior to Hepatectomy May Guide the Indication for Portal Vein Occlusion and Avoid Posthepatectomy Liver Failure: A Prospective Interventional Study. HPB (Oxford), 19, 108-117. [Google Scholar] [CrossRef] [PubMed]
[45] Truant, S., Baillet, C., Fulbert, M., et al. (2019) Asymmetric Kinet-ics of Volume and Function of the Remnant Liver after Major Hepatectomy as a Key for Postoperative Outcome—A Case-Matched Study. HPB (Oxford), 22, 855-863. [Google Scholar] [CrossRef] [PubMed]
[46] Han, H., Hu, H., Wang, W.P., et al. (2017) Liver Failure after Hepatectomy: A Risk Assessment Using the Pre-Hepa- tectomy Shear Wave Elastography Technique. European Journal of Radiology, 86, 234-240.
[47] Lei, J.-W., Ji, X.-Y., Hong, J.-F., et al. (2017) Prediction of Posthepatectomy Liver Failure Using Transient Elastography in Patients with Hepatitis B Related Hepatocellular Carcinoma. BMC Gastroenter-ology, 17, 171. [Google Scholar] [CrossRef] [PubMed]
[48] Squires III, M.H., Dann, G.C., Lad, N.L., et al. (2014) Hypo-phosphataemia after Major Hepatectomy and the Risk of Post-Operative Hepatic Insufficiency and Mortality: An Analy-sis of 719 Patients. HPB (Oxford), 16, 884-891. [Google Scholar] [CrossRef] [PubMed]
[49] Salem, R.R. and Tray, K. (2005) Hepatic Resection-Related Hypophos-phatemia Is of Renal Origin as Manifested by Isolated Hyperphosphaturia. Annals of Surgery, 241, 343-348. [Google Scholar] [CrossRef] [PubMed]
[50] Nafidi, O., Lepage, R., Lapointe, R.W. and D’Amour, P. (2007) Hepatic Resection-Related Hypophosphatemia Is of Renal Origin as Manifested by Isolated Hyperphosphaturia. Annals of Surgery 245, 1000-1002. [Google Scholar] [CrossRef
[51] Nomura, K., Tatsumi, S., Miyagawa, A., et al. (2014) Hepa-tectomy-Related Hypophosphatemia: A Novel Phosphaturic Factor in the Liver-Kidney Axis. Journal of the American Society of Nephrology, 25, 761-772. [Google Scholar] [CrossRef
[52] Takahashi, K., Murata, S. and Ohkohchi, N. (2013) Novel Therapy for Liver Regeneration by Increasing the Number of Platelets. Surgery Today, 43, 1081-1087. [Google Scholar] [CrossRef] [PubMed]
[53] Maruyama, T., Murata, S., Takahashi, K., et al. (2013) Platelet Transfusion Improves Liver Function in Patients with Chronic Liver Disease and Cirrhosis. The Tohoku Journal of Ex-perimental Medicine, 229, 213-220. [Google Scholar] [CrossRef] [PubMed]
[54] 梅理祥, 李增博, 谢艳会, 等. 肝切除术后第3天ICG-R15对肝细胞肝癌术后肝功能不全的预测价值[J]. 中国普通外科杂志, 2016, 25(8): 1180-1185. [Google Scholar] [CrossRef