可溶性ST2在急性心肌梗死后预测价值的研究进展
Progress in Investigating the Predictive Value of Soluble ST2 after Acute Myocardial Infarction
DOI: 10.12677/ACM.2023.131082, PDF,   
作者: 王振华, 陈凤英*:内蒙古医科大学附属医院急诊内科,内蒙古 呼和浩特
关键词: 可溶性ST2蛋白(sST2)急性心肌梗死PCI术后预测价值Soluble ST2 Protein (sST2) Acute Myocardial Infarction PCI Predictive Value
摘要: 可溶性ST2 (sST2)是近年来心血管疾病研究领域的一个很重要的新型生物标志物,是白介素1受体家族成员之一。其特异性配体为白细胞介素33 (IL-33)。IL-33/ST2L信号通路参与多种疾病的发生与发展,其中可介导急性心肌梗死后的抗心肌纤维化等心脏保护作用。而sST2作为IL-33的诱骗受体阻断信号通路的心脏保护作用,近年来被发现可用于预测急性心肌梗死后幸存患者的预后。
Abstract: Soluble ST2 (sST2) is an important new biomarker in the field of cardiovascular disease research in recent years. It is a part of the interleukin 1 receptor family. The specific ligand is interleukin 33 (IL-33). The IL-33/ST2L signaling pathway is involved in the occurrence and development of various diseases, which can mediate the cardioprotective effects such as anti-myocardial fibrosis after acute myocardial infarction. And the cardioprotective effect of sST2 as a decoy receptor-blocking signaling pathway for IL-33 has recently been found to predict the prognosis of the patients surviving it after acute myocardial infarction.
文章引用:王振华, 陈凤英. 可溶性ST2在急性心肌梗死后预测价值的研究进展[J]. 临床医学进展, 2023, 13(1): 564-570. https://doi.org/10.12677/ACM.2023.131082

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