TEAD2在恶性肿瘤中的作用及研究进展
The Role of TEAD2 in Malignant Tumors and Research Progress
DOI: 10.12677/ACM.2023.131086, PDF,   
作者: 吴若卿, 王 昊, 肖 辉：哈尔滨医科大学附属第二医院，黑龙江 哈尔滨
关键词: TEAD2；Hippo信号通路；EMT；恶性肿瘤；TEAD2； Hippo Signaling Pathway； EMT； Malignancy
摘要: TEAD2是转录因子TEAD家族之一，它参与了许多信号通路，尤以Hippo信号通路最为显著。与转录共激活因子YAP和TAZ结合，及促进EMT的过程，使其在人类恶性肿瘤发生发展的过程中发挥着重要作用。多篇文献报道证实了TEAD2可促进肝癌、肺癌、乳腺癌等恶性肿瘤的进展。本文总结了TEAD2在各种癌症中的研究进展及相关作用，在不同的癌症中观察到的TEAD2的明显致癌作用以及TEAD2促进癌症的机制为癌症治疗的潜在靶向性提供了一定的基础。
Abstract: TEAD2 is one of the transcription factor TEAD family, which is involved in many signaling pathways, especially the Hippo signaling pathway is the most prominent. The combination with transcription-al co-activators YAP and TAZ, and the process of promoting EMT, make it play an important role in the development of human malignant tumors. Several reports in the literature have confirmed that TEAD2 promotes the progression of malignant tumors such as hepatocellular carcinoma, lung can-cer, and breast cancer. In this paper, we summarize the research progress and related roles of TEAD2 in various cancers. The apparent oncogenic effects of TEAD2 observed in different cancers and the mechanisms of TEAD2 promotion in cancer provide some basis for the potential targeting of cancer therapy.
文章引用：吴若卿, 王昊, 肖辉. TEAD2在恶性肿瘤中的作用及研究进展[J]. 临床医学进展, 2023, 13(1): 588-594. https://doi.org/10.12677/ACM.2023.131086

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