残余胆固醇与2型糖尿病患者发生急性心肌梗死的相关性研究
The Relationship between Residual Cholesterol and Acute Myocardial Infarction in Patients with Type 2 Diabetes
摘要: 目的：探讨急性心肌梗死(AMI)合并2型糖尿病(T2DM)患者的非传统血脂指标与冠状动脉病变的关系。方法：收集我院2020年1月至2020年6月期间住院行冠状动脉造影检查明确诊断为AMI的患者202例，其中T2DM患者122例(糖尿病组)，非T2DM患者80例(非糖尿病组)，另外选取同期住院的非T2DM非冠心病患者81例(对照组)。收集研究对象的临床相关资料，比较分析三组患者的血脂水平差异及冠状动脉病变特点。结果：两组AMI患者血残余胆固醇(RC)、非高密度脂蛋白胆固醇(non-HDL)、甘油三酯(TG)水平均高于对照组，差异具有统计学意义(P < 0.05)，两组AMI患者血高密度脂蛋白胆固醇(HDL)水平均低于对照组，差异具有统计学意义(P < 0.05)。患者低密度脂蛋白胆固醇(LDL)和总胆固醇(TC)差异不具有统计学意义(P > 0.05)。ROC中RC曲线下面积为0.728，高于其他血脂指标。结论：首先糖尿病合并急性心肌梗死患者较单纯心肌梗死患者的冠脉病变分布广泛；其次RC与急性冠脉综合征发病有关，且在急性心肌梗死诊断中有一定的预测价值。
Abstract: Objective: To investigate the relationship between non-traditional blood lipid indexes and coronary artery disease in patients with acute myocardial infarction (AMI) and type 2 diabetes (T2DM). Methods: 202 patients with AMI diagnosed by coronary angiography in our hospital from January 2020 to June 2020 were collected, including 122 patients with T2DM (diabetes group), 80 patients with non-T2DM (non diabetes group), and 81 patients with non-T2DM and non coronary heart dis-ease (control group). Collect the clinical related data of the subjects, and analyze the differences of blood lipid levels and the characteristics of coronary artery lesions in the three groups. Results: The levels of blood residual cholesterol (RC), non high density lipoprotein cholesterol (non HDL) and tri-glyceride (TG) in the two groups of AMI patients were higher than those in the control group, and the difference was statistically significant (P < 0.05); The level of high density lipoprotein cholester-ol (HDL) in the two groups of AMI patients was lower than that in the control group, and the differ-ence was statistically significant (P < 0.05). There was no significant difference between patients with low density lipoprotein cholesterol (LDL) and total cholesterol (TC) (P > 0.05). The area under RC curve in ROC was 0.728, higher than other blood lipid indicators. Conclusion: First of all, the cor-onary lesions in patients with Type 2 diabetes complicated with acute myocardial infarction are more widespread than those in patients with simple myocardial infarction; Secondly, RC is related to the onset of acute coronary syndrome, and has certain predictive value in the diagnosis of acute myocardial infarction.
文章引用：韩晓荣, 宋康, 菅传敏, 刘松. 残余胆固醇与2型糖尿病患者发生急性心肌梗死的相关性研究[J]. 临床医学进展, 2023, 13(1): 707-713. https://doi.org/10.12677/ACM.2023.131103

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