LncRNA CRNDE在肾母细胞瘤中的表达及其临床意义

Expression and Clinical Significance of Long Non-Coding RNA CRNDE in Wilms Tumor

摘要: 目的：本研究是为了探讨长链非编码RNA (LncRNA) CRNDE在肾母细胞瘤中的表达以及它的预后意义。方法：通过实时荧光定量PCR技术检测CRNDE在肾母细胞瘤组织中的表达水平；采用卡方检验确定CRNDE表达与肾母细胞瘤患者临床病理指标的相关性。最后利用Kaplan-Meier曲线、对数秩检验和Cox分析阐明CRNDE在肾母细胞瘤中的临床意义。结果：肿瘤组织中的CRNDE表达水平较癌旁组织高；CRNDE表达水平的高低与临床分期、病理分型以及有无淋巴结转移相关。CRNDE的过度表达可作为肾母细胞瘤患者预后不良的独立预测因子。结论：CRNDE在肾母细胞瘤组织中高表达，高CRNDE表达的患者预后不良，提示我们CRNDE可能是肾母细胞瘤患者相关预后/治疗的潜在靶点。关于肾母细胞瘤中CRNDE的意义需要更多的研究深入探讨。

Abstract: Objective: The aim of this study was to investigate the expression and prognostic significance of the long non-coding RNA (LncRNA) CRNDE in Wilms tumor. Methods: First, we detect the expression level of CRNDE in Wilms tumor tissues by real-time quantitative reverse transcription polymerase chain reaction. Then determine correlation between CRNDE expression and clinicopathological pa-rameters of patients with Wilms tumor by chi-square test. Finally, we use Kaplan-Meier curve, log-rank test and Cox analysis to clarify the clinical significance of CRNDE in Wilms tumor. Results: The expression of CRNDE was increased in patients with Wilms tumor, and the expression level was related to the clinical stage, pathological type and lymph node metastasis. Meanwhile, the overex-pression of CRNDE can be used as an independent predictor of the prognosis of patients with Wilms tumor. Conclusion: CRNDE is highly expressed in Wilms tumor tissues, and patients with high CRNDE expression have poor prognosis, suggesting that CRNDE may be a potential prognos-tic/therapeutic target for Wilms tumor patients. More studies are needed to explore the signifi-cance of CRNDE in Wilms tumor.